Innovative Bulk Drying of Frozen Microspheres by Spray-Freeze-Drying
|
|
- Giles Sims
- 6 years ago
- Views:
Transcription
1 Boston, May 17 th, AAPS National Biotechnology Conference Session: Next-Generation Drying Technologies for Processing of Biotherapeutics (#118) Innovative Bulk Drying of Frozen Microspheres by Spray-Freeze-Drying Bernhard LUY MERIDION Technologies, Germany
2 Topics Background of the Development Presentation of two Core Technologies Spray Freezing Dynamic Bulk Freeze Drying Case Study of an Industrial Project for a pharmaceutical product Potential Impact of Technology on process product innovation production logistics 2
3 BioTherapeutics Pharmaceutical Sciences Slide with kind permission from S. Tchessalov, New life of spray freeze-drying- application to dehydration of protein solutions PepTalk Conference 2016, San Diego CA Recent literature on spray-freeze drying Werly, E.P., Baumann, E.K., Production of submicronized powder by spray freezing.arch. Environ. Health 9, S.Wanning, R.Süverkrüp, A.Lamprecht. Pharmaceutical spray freeze drying, Intern. J. of Phramaceutics, 488 (2015) Carpenter JF, Pham BV, Randolph T, Seid R, Truong-Le V Spray freeze dry of compositions for pulmonary administration. WO Leuenberger H, Plitzko M, Puchkov M Spray freeze drying in a fluidized bed at normal and low pressure. Drying Technol 24(6): Cheow WS, Ng ML, Kho K, Hadinoto K Spray-freeze-drying production of thermally sensitive polymeric nanoparticle aggregates for inhaled drug delivery: Effect of freeze-drying adjuvants. Int J Pharm 404(1 2): Gao Y, Zhu CL, Zhang XX, Gan L, Gan Y Lipid-polymer composite microspheres for colon-specific drug delivery prepared using an ultrasonic spray freeze-drying technique. J Microencapsul 28(6): Dolly P, Anishaparvin A, Joseph GS, Anandharamakrishnan C Microencapsulation of Lactobacillus plantarum (mtcc 5422) by spray-freezedrying method and evaluation of survival in simulated gastrointestinal conditions. J Microencapsul 28(6):
4 Background Typical Limitations of conventional FD static drying (under vacuum) offers only limited heat & mass transfer heat transfer has to occur across frozen product vapor flow limitations, e.g. diffusion barrier thickness product inhomogeneities may occur (e.g. caking, density variations) product handling properties (e.g. flowability, dust) primary packaging requirements production logistics 4 4
5 Background / History: Specific past R&D work performed Research Project at Basel School of Pharmacy (Prof. Hans Leuenberger): Atmospheric Spray Freeze Drying in Fluidized Bed Operations started in the mid 80s (in coop. with Glatt GmbH) 3 research projects realized until the mid 90s 5 5
6 Background / History: Specific past R&D work performed Atmospheric Spray Freeze Drying in Fluidized Bed Result of Research Work: 3 step process required (spray freezing (air temp. < -60 C); primary drying (T p : <-10 C), secondary drying at amb. temp.) very low water uptake of cold air requires long drying times and / or excessive air flow; filter drying required due to freezing requirements (air velocity) Conclusion: Single pot processing not feasible, but need to separate into two process steps of particle formation and dynamic bulk freeze drying to achieve product movement by air fluidization: possible, but inefficient (design constraints) 6
7 Two new Process Steps : Spray Freezing & Dynamic Bulk FD A: Spray Freezing: Frozen microspheres are generated as bulk by dispersing the substrate liquid using frequency nozzles into single droplets, which by gravity pass through a cooling zone, congealing to frozen spheres (ambient pressure). B: Dynamic Bulk Freeze Drying: free flowing frozen bulkware is lyophilized in a rotational vacuum freeze dryer under constant gentle mixing. Sublimation energy is transferred by radiation and temperature controlled surfaces. 7
8 Spray Freezing Generation of frozen bulk product (nozzle) insulation temperature probes double wall 8
9 Spray Freezing: Droplet Generation Controlled laminar jet break up droplet generation by frequency (but low shear/pressure stress) droplet size: 250 µm µm in-process control (# of droplets) throughput : 1 1,8 l/h / nozzle (droplet size vs throughput) formulation requirements 9
10 Spray Freezing Temperature Profile during Freezing 10
11 Spray Freezing Resulting Product Properties frozen pellets in the required particle size (no milling or sieving required) homogeneous (e.g. in size, composition, nucleation) dust free good flowability small particles with large surface large surface area for mass and heat transfer short diffusion length for water vapour 11
12 Dynamic Freeze Drying Bulk Freeze drying in a Rotating Drum Product is in constant movement the entire surface is available for heat and mass transfer intrinsically, the process provides for product homogeneity and constant homogeneous process conditions for the entire batch allows direct measurement of product (environment) temperature 12
13 Dynamic Freeze Drying Rotary Freeze Dryer for Bulk Freeze Drying Main components: vacuum housing with rotating drum; condensor; heat source(s) charging rotary joint cantilevered drum discharging condensor 13
14 Dynamic Freeze Drying Drying Profile (without pressure regulation) 14
15 Dynamic Freeze Drying Product Movement During Drying 15
16 Product properties (freeze dried 20%sucrose solution) good flowability residual moisture < 1% bulk density: 0.18 g/cm³ dust free yield 95.6 % narrow particle size distribution 16
17 Dynamic Freeze Drying Process Characteristics increased heat & mass transfer (30 50% drying time reduction) homogenous drying conditions due to constant, gentle mixing of product (no edge effects as compared to conventional shelf freeze drying) direct measurement of process relevant parameters visual inspection of product flow behavior (stickiness if exceeding glass transition temperature) contained charging and discharging possible formulation requirements (size of particles vs vapour flow; binding agent) in process-adjustments of sublimation rate (to prevent vapor-based entrapment of pellets) 17
18 Innovative Bulk Freeze Drying of Microspheres Case Study of an Integrated Manufacturing Line Process Line Setup Product Handling / Containment Aspects Innovation Potential 18
19 Process Line Setup Transfer Liquid Vessel : Nozzle Spray congealing chamber Transfer to dryer, incl. vacuum flap Rotary freeze dryer w. closed charging & closed discharging Transfer tube Discharge vessel & filling of IBCs 19
20 Process Line Setup Process Line Characteristics integration of two main process steps: particle generation & dynamic freeze drying incl. transfer product flow by gravity & internal drum discharging; no need for loading/unloading in sterile area process line with total containment (incl. WiP/CiP & SiP) no open handling of product: room classification (cost impact, e.g. on analytics) 20
21 Production size process line freezing chamber with spray section and cooling area transfer section to dryer rotary freeze dryer with double wall drum and IR heating radiators discharge section to intermediate hopper for discharge 21 21
22 Production size process line Freezing chamber Freezing Chamber Spray Section with liquid feed by peristaltic pump 4 frequency nozzles droplet counter for IPC CiP / SiP feed lines 22 22
23 Production size process line: Rotary freeze dryer Rotary Freeze Dryer with 23 double wall vacuum housing cantilevered double wall drum with mixing baffles & discharge scoops CiP/ SiP feed lines designed for 100 l (liquid) range: 10l. 150 l scale up considerations 23
24 Production size process line: Rotary freeze dryer, front section Front Lid of Rotary Freeze Dryer with charge tube from transfer section for gravity drum loading IR radiator, fully glass covered & temp. controlled discharge funnel for contained discharge by reverse roatation 24 24
25 Scale Down of Technologies 25 technologies available in Lab Size min. load ca. 150 / 200 ml, up to ca. 1 l (liquid) for feasibility testing
26 Innovation Potential: (1) (process) (2) product related (3) free flowing, dust free lyophilized bulkware 26
27 Innovation Potential Product high homogeneity (e.g. nucleation uniformity) physical properties allow for accurate filling reduction of reconstitution time due to large surface filling of different products (compounding) Solid Dos. Form technologies applicable (e.g. coating, ODT formulations) suited for Containment applications (dust free appearance) 27
28 Innovation Potential Lyophilized Bulkware physical properties are prerequisite for subsequent filling homogeneous,lyophilized bulkware allows for filling on demand (independent of liquid prep. process) dosing flexibility no need for primary packaging to be suited for the lyophilization process (e.g. vial to vial variability) allows for reduced time to market or DS cold chain requirement 28
29 Conclusion Dynamic freeze drying resulting in free flowing, dust free bulkware allows for product innovation process innovation process specific aspects manufacturing logistics innovation: fill when. how much.. of what.. into what... you want 29
30 Acknowledgements Matthias Plitzko Thomas Gebhard (Meridion Technologies) Serguei Tchessalov (Pfizer Inc) contact: 30
Continuous Lyophilization of Pharmaceutical Products in Unit Doses
Hudson Valley LyoMac Webinar -May 30, 2018 Continuous Lyophilization of Pharmaceutical Products in Unit Doses Roberto Pisano Department of Applied Science and Technology POLITECNICO di TORINO e-mail: roberto.pisano@polito.it
More informationContinuous freeze-drying and its relevance to the pharma/biotech industry
Engineering Conferences International ECI Digital Archives Integrated Continuous Biomanufacturing III Proceedings 9-19-2017 Continuous freeze-drying and its relevance to the pharma/biotech industry Roberto
More informationAuthor: JOHN BARLEY, PRODUCT MANAGER, SP INDUSTRIES INC.
Page: 1 of 14 Author: JOHN BARLEY, PRODUCT MANAGER, SP INDUSTRIES INC. OVERVIEW Freeze drying is the removal of ice or other frozen solvents from a material through the process of sublimation and the removal
More informationFreeze drying and alternative technologies for drying of biopharmaceutical products
Freeze drying and alternative technologies for drying of biopharmaceutical products PDA Israel Chapter Basics and Recent Developments for Autoclaves and Lyophilizers Dan Accadia Hotel, Herzliya 13.11.2017
More informationRoller Compactors. for the Pharmaceutical Industry
Roller Compactors for the Pharmaceutical Industry Roller Compactors for the Pharmaceutical Industry Granular Materials in Pharmaceutical Production 75% of pharmaceutical remedies and preparations are administered
More informationPractical Design Requirements For New Lyophilization Equipment
Practical Design Requirements For New Lyophilization Equipment PDA Israeli Chapter Lyophilization & sterilization conference 13/11/2017 Yossi Shapira Teva Pharm. Ind. Freeze Drying Expert Slide Title FDA
More informationLÖDIGE ALWAYS THE RIGHT MIX
System Solutions for the Pharmaceutical Industry www.loedige.de LÖDIGE ALWAYS THE RIGHT MIX 1 Pharmaceutical Industry High-Tech Made by People for People 2 www.loedige.de Product-specific process design
More informationDrying rate 1. Section B to C of the curve, known as the constant rate periods, represents removal of unbound water from the product.
Drying rate 1 Drying process of a material can be described as a series of steps in which drying rate plays a key role. Following figure shows typical drying rate curve for a constant drying conditions.
More informationIRD INFRARED ROTARY DRUM HEATING. DRYING. CRYSTALLIZING. COATING.
IRD INFRARED ROTARY DRUM HEATING. DRYING. CRYSTALLIZING. COATING. MINIMAL PROCESSING TIMES HIGH FLEXIBILITY LOW ENERGY CONSUMPTION KREYENBORG is a leading provider of solutions in the field of bulk material
More informationIntroduction to Pharmaceutical Freeze Drying
Introduction to Pharmaceutical Freeze Drying David Debo, PE Date 1 Agenda Introduction Stages of the process System components 2 Introduction What is lyophilization? What is sublimation? Why freeze dry?
More informationIRD INFRAROT DREHROHR IRD INFRARED ROTARY DRUM ERWÄRMEN. TROCKNEN. KRISTALLISIEREN. COATEN. HEATING. DRYING. CRYSTALLIZING. COATING.
IRD INFRAROT DREHROHR IRD INFRARED ROTARY DRUM ERWÄRMEN. TROCKNEN. KRISTALLISIEREN. COATEN. HEATING. DRYING. CRYSTALLIZING. COATING. 1 MINIMAL PROCESSING TIMES HIGH FLEXIBILITY LOW ENERGY CONSUMPTION 2
More informationA comparison of Vacuum Drying Processes of Food Products
A comparison of Vacuum Drying Processes of Food Products VII CTC Symposium Murcia 14th May 2015 Pierre LANTHEAUME Oerlikon Leybold Vacuum Global Market Segment Manager - Food and Packaging pierre.lantheaume@oerlikon.com
More informationPowder Technology Division. Niro. Fluidized Spray Dryer FSD
Powder Technology Division Niro Fluidized Spray Dryer FSD Fluidized Spray Dryer FSD The Fluidized Spray Dryer FSD is one of the most successful designs of spray dryers ever developed. It is used to dry
More informationLYOPHILIZATION- THE PROCESS AND INDUSTRIAL USE
198 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 6(2): March-April 2017 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND BIO
More informationPneumatic Vacuum Conveying: an Easy Clean, Efficient, and Safe Mode of Transfer for Difficult or Harmful Pharmaceutical Powders
Pneumatic Vacuum Conveying: an Easy Clean, Efficient, and Safe Mode of Transfer for Difficult or Harmful Pharmaceutical Powders Introduction Powder transfer by pneumatic vacuum conveying has become one
More informationA Revolution in Lyophilization. The small freeze dryer with. Introducing the
i A Revolution in Lyophilization. The small freeze dryer with Introducing the MicroFD results The MicroFD with groundbreaking LyoSim TM and LyoPAT with LyoSim TM & LyoPAT This is what this freeze dryer
More informationPelletizing System Options for Extrusion
Pelletizing System Options for Extrusion by Dana Darley Extrusion Auxiliary Serv ices Dacula, GA (678) 714-5218 www.extrusionauxiliary.com Types of Pelletizing Systems Strand Water Bath Strand Water Slide
More informationHICOSYS FOR PROCESS CONTROL OF SPRAY DRYERS
1/7 HICOSYS FOR PROCESS CONTROL OF SPRAY DRYERS CAPACITY INCREASE AND FOULING REDUCTION BY MEASURING HUMIDITY OF DRYING AIR? In spray drying processes capacity of the dryer is partly determined by the
More informationMini Spray Dryer B-290 Technical data sheet
Mini Spray Dryer B-290 Technical data sheet The Mini Spray Dryer B-290 is the world leading laboratory scale Spray Dryer since many years. It is designed to visualize your Spray Drying process for wide
More informationFluid Bed Processor LFP LÖDIGE ALWAYS THE RIGHT MIX
Fluid Bed Processor LFP LÖDIGE ALWAYS THE RIGHT MIX Innovative Fluid Bed Technology for pharmaceutical and chemical products The Lödige Fluid Bed Processor is designed for: Drying Instantising Granulating
More informationSPECIALIZED EQUIPMENT
MIXING & BLENDING SPECIALIZED EQUIPMENT For Challenging Applications Bepex International s mixing and blending equipment has been serving industries around the world for decades. Bepex combines the extensive
More informationCROP PROTECTING AGENTS. Drying, mixing, milling, agglomeration/extrusion, deaeration & containment. Process technologies for tomorrow.
CROP PROTECTING AGENTS Drying, mixing, milling, agglomeration/extrusion, deaeration & containment. Process technologies for tomorrow. ALL THE PROCESS TECHNOLOGIES YOU NEED One-stop shopping for the agrochemical
More informationHOW TO SELECT AN INDIRECT THERMAL TECHNOLOGY FOR INDUSTRIAL MATERIALS PROCESSING
white paper HOW TO SELECT AN INDIRECT THERMAL TECHNOLOGY FOR INDUSTRIAL MATERIALS PROCESSING Better Thermal Processing Results Begin with Selecting the Right Technology Authored by Rob Grady Director of
More informationSimply Plug and Convey
Simply Plug and Convey Pneumatic vacuum transfer is the smart choice for powder and bulk material transfer By: Nick Hayes, President, Volkmann, Inc. and Thomas Ramme, Dipl.-lng. B.Eng. (Hons.), Volkmann
More informationPROCELL LABSYSTEM. direct pelletization. Glatt. Integrated Process Solutions.
PROCELL LABSYSTEM Spray granulation Spray Agglomeration Spray Coating Spray encapsulation powder layering direct pelletization Glatt. Integrated Process Solutions. I1 mm I I1 mm I micro organisms, spray
More information2How does a vibratory fluid-bed dryer work?
As appeared in April 2011 PBE Copyright CSC Publishing www.powderbulk.com Answers to five common questions about vibratory fluid-bed dryers Doug Schieber Carrier Vibrating Equipment A vibratory fluid-bed
More informationAccessories. for perfect freeze drying
Accessories for perfect freeze drying Accessories for perfect freeze drying Martin Christ Gefriertrocknungsanlagen GmbH Postfach 1713 37507 Osterode am Harz Tel. + 49 5522 5007-0 Fax + 49 5522 5007-12
More informationTitle of the paper: Principles of Food Processing F04PF21 FREEZE DRYING AND ROTARY DRYING PROCESS Dr. P. Suganya
Introduction Freeze drying is a low thermal processing method to preserve food materials. Freeze drying process was initiated during Second World War period in order to preserve the foods. Further this
More informationPneumatic Conveying System PCS
Pneumatic Conveying System PCS Certified according ATEX regulations GMP compliant Energy saving Reliable Reduced maintenance Easy to operate We set the standard Transport via vacuum Flexible, dust-free
More informationFreeze Dryer (Lyophilizer) Catalog
Freeze Dryer (Lyophilizer) Catalog Esquire Biotech (SSI Unit) Plot,3. Door No.1/150, Kamkshi Nagar, Mugalivakkam Chennai-600125, India. Website: www.lyophiliser.com Contact person: A.Sivasankar Email:
More informationA study of vial headspace moisture in an entire freeze dried batch and the factors affecting moisture content variability
A study of vial headspace moisture in an entire freeze dried batch and the factors affecting moisture content variability Isobel Cook Principal Scientist Biopharma Technology Limited specialists in freeze
More information(12) Patent Application Publication (10) Pub. No.: US 2014/ A1
(19) United States US 20140245629A1 (12) Patent Application Publication (10) Pub. No.: US 2014/0245629 A1 Luy et al. (43) Pub. Date: (54) PROCESS LINE FOR THE PRODUCTION OF Publication Classification FREEZE-DRED
More information-Technology an Enabler for Instantaneous Post Printing Processes
Dr. Kai K. O. Bär adphos Digital Printing GmbH, Bruckmühl/Germany -Technology an Enabler for Instantaneous Post Printing Processes NIR is a trademark of adphos. adphos owns more than 200 patents- or patent
More informationQAQC LABS ANALYTICAL DRYING
WHAT IS FLUID BED? By forcing enough air through a bed of particles, the particle bed may assume a fluid-like state (resembling a boiling liquid). Heating the incoming air and managing air flow rate through
More informationVacuum - The Universal Conveying Force Suction and transportation of powders, liquids and gases
Vacuum - The Universal Conveying Force Suction and transportation of powders, liquids and gases Thomas Ramme Dipl.-ing B.Eng.(Hons.), Nick Hayes MCMI Dip IM With the introduction of the ATEX guidelines
More informationBy Barry A. Perlmutter, Managing Director. Solid-Liquid Separation Cake Washing & Drying Technologies.
Solid-Liquid Separation Cake Washing & Drying Technologies April 2002 www.chemicalprocessing.com Evaluating thin-cake pressure filtration using the BHS Autopress technology Thin-cake pressure filtration
More informationSIZE REDUCTION TECHNOLOGY
SIZE REDUCTION TECHNOLOGY HOSOKAWA BEPEX Size Reduction Technology Process Solutions for Granulation Requirements BEPEX offers a variety of techniques tailored to meet the requirements of your business.
More informationOur delivery program is covering most of the critical steps within the field of Formulation.
PHARMACEUTICAL Our delivery program is covering most of the critical steps within the field of Formulation. From small scale to industrial production we could be your partner for building up your complete
More informationGEA pharmaceutical spray drying. Improve drug properties and production efficiency with spray drying
GEA pharmaceutical spray drying Improve drug properties and production efficiency with spray drying 2 PHARMA Industry-leading technology Spray drying is a technique preferred by a growing number of pharmaceutical
More informationCHEM-3140 Bioprocess technology II. Drying and Crystallization
CHEM-3140 Bioprocess technology II Drying and Crystallization Tamer Alhalabi Kalle Koikkalainen Lee Suen Ern Date: 05.12. 2017 Table of Contents Drying and Crystallization Table of Contents 1.0 Abstract
More informationINCREASE YOUR LAB EFFICIENCY
INCREASE YOUR LAB EFFICIENCY CoolSafe How to configure your freeze dryer Scandinavian by Design THE PROCESS PRE-FREEZING, PRIMARY DRYING & SECONDARY DRYING THE BASIC PRINCIPLE: Freeze drying is a process
More informationMASS TRANSFER. Theory and Practice. N. ANANTHARAMAN Professor Department of Chemical Engineering National Institute of Technology Tiruchirappalli
MASS TRANSFER Theory and Practice N. ANANTHARAMAN Professor Department of Chemical Engineering National Institute of Technology Tiruchirappalli K.M. MEERA SHERIFFA BEGUM Associate Professor Department
More informationPneumatic Vacuum Conveyors for the Highest Standards Transportation of bulk materials in the pharmaceutical and chemical industries
Pneumatic Vacuum Conveyors for the Highest Standards Transportation of bulk materials in the pharmaceutical and chemical industries VOLKMANN Inc. In process technology there is a frequent requirement for
More informationGFD POWDER SYSTEMS LIMITED
GFD TM POWDER SYSTEMS LIMITED POWDER SYSTEMS LIMITED PSL BELIEVES IN WORLD CLASS PEOPLE WORKING TOGETHER TO PROVIDE WORLD CLASS SOLUTIONS. Our experienced engineering teams work closely with our skilled
More informationLoad type and process/autoclave selection
Load type and process/autoclave selection PDA Europe Basics and Recent Developments for Autoclaves and Lyophilizers - Tel Aviv/Israel, 13 November 2017 Sara Ferretti Fedegari Group What load can we treat
More informationCustomers. The core of our innovation. Feeding&Conveying. Drying Dosing Temperature Control Refrigeration Granulation
EN Customers. The core of our innovation Feeding&Conveying Drying Dosing Temperature Control Refrigeration Granulation Piovan Drying Technologies: Desiccant Bed Dryers Dried air is generated by means of
More informationAnhydro Spray Drying FOR THE PHARMACEUTICAL INDUSTRY
Anhydro Spray Drying FOR THE PHARMACEUTICAL INDUSTRY SPX Flow Technology Danmark A/S is an international engineering company with a consistent goal to provide our customers with the optimal processing
More informationBest Freeze Drying Solutions
Best Freeze Drying Solutions The ultimate plus Pilot Freeze Dryers Epsilon 2-6D LSCplus Epsilon 2-10D LSCplus 2 Best Drying Results Advanced System Technology for Best Drying Results The freeze dryer EPSILON
More informationPERFIMA COATING PAN FOR FILM AND SUGAR PROCESSES
PERFIMA COATING PAN FOR FILM AND SUGAR PROCESSES PERFIMA PERFIMA IS A FLEXIBLE AND RELIABLE MACHINE PROVIDING THE HIGHEST EFFICIENCY IN THE FIELD OF AUTOMATIC COATING EQUIPMENT. The machine is available
More informationRational approaches and transfer strategies for the scale-up of freeze-drying cycles
Scientific article - eer reviewed RESS DEVELMET Stefan. Schneid Rational approaches and transfer strategies for the scale-up of freeze-drying cycles STEFA. SEID1,2*, EIG GIESELER1 *orresponding author
More informationGrinding & Dispersing. Ψ-MIX Inline-Disperser A revolutionary system for mixing and dispersing of solids in liquids. our technology YOUR SUCCESS
Grinding & Dispersing Ψ-MIX Inline-Disperser A revolutionary system for mixing and dispersing of solids in liquids our technology YOUR SUCCESS Ψ-MIX Inline-Disperser Innovative Dispersion Technology With
More informationMini Spray Dryer B-290 Technical data sheet
Mini Spray Dryer B-290 Technical data sheet The Mini Spray Dryer B-290 is the world leading laboratory scale Spray Dryer since many years. It is designed to visualize your Spray Drying process for wide
More informationDense phase. Pneumatic conveying. Main advantages. Vacuum conveying - Working principle. Positive and negative conveying pressure.
Pneumatic conveying Jetsolutions provides the best solution to transfer bulk materials, using pneumatic conveying systems adapted to the process and the product. Our transfer systems are designed to work
More informationMIXING AND OTHER PROCESSING EQUIPMENT FROM THE HEART OF EUROPE
EMA Austria GMBH MIXING AND OTHER PROCESSING EQUIPMENT FROM THE HEART OF EUROPE Planetary mixers: Mixema Plamix Planetary mixers are used in the pharmaceutical, chemical, food and other industries for
More informationROTARY DRYER CONSTRUCTION
ROTARY DRYER The Rotary Dryer is a type of industrial dryer employed to reduce or to minimize the liquid moisture content of the material it is handling by bringing it into direct contact with a heated
More informationREVIEW ON SPRAY DRYING TECHNOLOGY
REVIEW ON SPRAY DRYING TECHNOLOGY Shahrukhkhan pathan 1, Prof. S B Thakore 2 2. 1. Student, Chemical Engg. (CAPD) LDCE, Ahmedabad, Gujarat, India Associate Professor, Chemical Engg. Dept., LDCE, Ahmedabad,
More informationPLC Control Touch-Screen
Almost all laboratory freeze-drying processes can be carried out using this basic unit and the wide range of accessories available. The 4K incorporates a stainless steel cooled trap that can be easily
More informationLABORATORY FREEZE DRYERS ADVANCED PROCESSES
LABORATORY FREEZE DRYERS ADVANCED PROCESSES IMA LIFE FREEZE DRYING SOLUTIONS. THE BEST IN FREEZE DRYING TECHNOLOGY THE BEST IN FREEZE DRYING TECHNOLOGY LABORATORY FREEZE DRYERS 6 UNCOMPROMISING PROCESS
More informationTransfer of a Legacy Product between Two Sites: How to improve Process Robustness by using Mathematical Models
Transfer of a Legacy Product between Two Sites: How to improve Process Robustness by using Mathematical Models E. Bourles 1, B. Scutella 1, B. Moreau 2, Y. Mayeresse 2 1 GSK Technical R&D Drug Product
More informationOptimization and Scale-Up
LyoStar 3 The Choice for Cycle Development, Optimization and Scale-Up Configured with the latest innovations in freeze-drying technology, the Lyostar 3 delivers pinpoint process control and robust reliability
More informationContinuously Improving Process Manufacturing
s3process.co.uk Continuously Improving Process Manufacturing R&D Equipment for Oral Solid Dosage Forms MILLING & SIEVING 2 POWDER BLENDING 3 DRY GRANULATION 4 WET GRANULATION & DRYING 6 TABLET COMPRESSION
More informationPSA Series. Particle Size Analyzer
PSA Series Particle Size Analyzer Particle size analysis by laser diffraction Anton Paar s PSA series incorporates more than fifty years of experience. The world's first laser diffraction particle size
More informationHow models improve our world Optimization of spray drying operations with NIZO Premia
How models improve our world Optimization of spray drying operations with NIZO Premia November 8 th, 2011 Matthew de Roode matthew.deroode@nizo.nl Han Straatsma Gert van Houwelingen Natalie Hotrum Peter
More informationDFE T ECHNOLOGY. At Conceptronic, the design and management process for reflow soldering systems is called Dynamic Flow Engineering, or DFE.
DFE T ECHNOLOGY As components become smaller, component mixes become more diverse, and board densities continue to increase, the processes of packaging, interconnection, and assembly are challenging the
More informationLÖDIGE ALWAYS THE RIGHT MIX
Lödige Coating System LC LÖDIGE ALWAYS THE RIGHT MIX 1 Coating Applications Lödige Coaters have been a success in film and sugar coating processes for various products since 1980. Coating technology has
More informationMixer and Blender Options for. Vacuum Drying Requirements
Mixer and Blender Options for Vacuum Drying Requirements A White Paper Prepared By Charles Ross & Son Company Mixer and Blender Options for Vacuum Drying Requirements Abstract Throughout the industries,
More informationDownstream Processing Prof. Mukesh Doble Department of Biotechnology Indian Institute of Technology, Madras. Lecture - 36 Drying
Downstream Processing Prof. Mukesh Doble Department of Biotechnology Indian Institute of Technology, Madras Lecture - 36 Drying We have been looking at several downstream, where you are trying to separate
More informationLAARMANN CM Power Cutting Mill. Superior Cutting Mill engineered for rapid reduction of large particles. Innovators in Solids
Power Cutting Mill CM 1000 Superior Cutting Mill engineered for rapid reduction of large particles Rapid reduction of large particles from 100mm to 0,5 mm Quick and easy to clean Full range of bottom sieves
More informationThe SPX World of Industrial Drying Technologies
The SPX World of Industrial Drying Technologies White Paper Table of Contents Introduction to SPX Flow Technology 3 Vision and commitment 3 Customer focus 3 Spray Dryers 4 Vacuum and freeze drying 6 Freeze
More informationINSTRUCTION MANUAL FOR Freeze Dry Systems PLEASE READ THIS MANUAL CAREFULLY BEFORE OPERATION
INSTRUCTION MANUAL FOR Freeze Dry Systems FDL-10N-50 series PLEASE READ THIS MANUAL CAREFULLY BEFORE OPERATION 3, Hagavish st. Israel 58817 Tel: 972 3 5595252, Fax: 972 3 5594529 mrc@mrclab.com MRC.VER.01-04.10
More informationSnack Production Plants
Snack Production Plants The Company Engineered Snacks HEBENSTREIT supplies automated extrusion plants for the production of savoury and sweet snacks. Our scope of supply ranges from the raw material mixer
More informationFLUIDIZED BED SPRAY GRANULATION: Equipment and Processing Considerations
FLUIDIZED BED SPRAY GRANULATION: Equipment and Processing Considerations David M. Jones OWI-Consulting Inc Email: djones@owi-consulting.com Phone/fax: 610-383-5091 Cell: 201-264-5173 Topics of the Presentation
More informationBiosolids dewatering using super absorbent polymers (SAPs) Mostafa M.Noureldin Illinois Institute of Technology
Biosolids dewatering using super absorbent polymers (SAPs) Mostafa M.Noureldin Illinois Institute of Technology Overview Super absorbent polymers (SAP) Biosolids management concerns Approach Results SAP
More informationDECOMMISSIONING OF THE REACTOR VESSEL OF THE COMPACT SODIUM COOLED NUCLEAR REACTOR FACILITY (KNK)
DECOMMISSIONING OF THE REACTOR VESSEL OF THE COMPACT SODIUM COOLED NUCLEAR REACTOR FACILITY (KNK) J. Benkert, F. Willman Westinghouse Electric Germany GmbH Mannheim / D K. Brockmann, I. Hillebrand Research
More informationDRYING OF MILK SPRAY DRYING
College of Agricultural Engineering and Technology Dept. of Agricultural Processing and Food Engineering Course : Dairy and Food Engineering Chapter 10 DRYING OF MILK (Objectives of milk drying, Spray
More informationDynamic Simulation of a CFB Boiler System
71th IEA-FBC Technical Meeting Dynamic Simulation of a CFB Boiler System 2015. 11. 05, Seoul, Korea Sang Min CHOI Thermal Engineering Lab Thermal Engineering Laboratory KAIST Introduction Dynamic Performance
More informationDRYING OF HEAT SENSITIVE MATERIALS OF HIGH MOISTURE CONTENT IN MECHANICALLY SPOUTED BED OF INERT PARTICLES
DRYING OF HEAT SENSITIVE MATERIALS OF HIGH MOISTURE CONTENT IN MECHANICALLY SPOUTED BED OF INERT PARTICLES Janos Gyenis 1, Elisabeth Pallai Varsányi 1 and Judit Tóth 2 1. Research Institute of Chemical
More informationGrinding & Dispersing. Submersible Basket Mill MASTERMILL The very Highest Degree of Efficiency. our technology YOUR SUCCESS
Grinding & Dispersing Submersible Basket Mill MASTERMILL The very Highest Degree of Efficiency our technology YOUR SUCCESS Submersible Basket Mill MASTERMILL The NETZSCH MASTERMILL is a batch-type basket
More informationFood Processing Equipment. NEAEN VarioT SCRAPED SURFACE HEAT EXCHANGERS
Food Processing Equipment NEAEN VarioT SCRAPED SURFACE HEAT EXCHANGERS NEAEN VarioT Scraped surface heat exchangers are the professional solution used in a variety of manufacturing processes, ensuring
More informationInternational Journal of Engineering Research (IJOER) [Vol-1, Issue-3, June- 2015]
Experimental Investigation To Develop The Refrigeration System With Two Phases Condensing Ejector Along With Energy Saving Anjani Kumar 1, Kuldip Kumar 2, Ujjwal Kumar Nayak 3 123 Department of mechanical
More informationLyophilization Product Line Overview
Lyophilization Product Line Overview Introduction Contents SP Scientific offers the broadest lyophilization range available, and is the only United States based manufacturer of complete aseptic vial fill-finish
More informationventing method will work for all pressure conveying systems, analyzing your available equipment, your material s characteristics, and your conveying c
Six practical ways to handle rotary leakage Jonathan O. Thorn MAC Equipment Because of the way a rotary is designed, it s normal for a small amount of conveying to leak back through the as it s bulk solid
More informationGEA Niro drying systems. We know what makes outstanding polymers. engineering for a better world. GEA Process Engineering
GEA Niro drying systems We know what makes outstanding polymers engineering for a better world GEA Process Engineering Meeting precise needs Benefits include: Tailor-made plants Fully scalable Energy efficient
More informationThe Logistics of Filling and Freeze Drying using Multiple Isolators. The use of isolator technology to fill and lyophilize pharmaceuticals
Courtesy of M & O Perry Industries, Inc. MANUFACTURING Peter Hanscome, Joe Rogalewicz, Jim Warakomski Aventis Pasteur The Logistics of and Freeze Drying using Multiple Isolators. The use of isolator technology
More informationFLIGHT UNLOADING IN ROTARY SUGAR DRYERS. P.F. BRITTON, P.A. SCHNEIDER and M.E. SHEEHAN. James Cook University
FLIGHT UNLOADING IN ROTARY SUGAR DRYERS By P.F. BRITTON, P.A. SCHNEIDER and M.E. SHEEHAN James Cook University Paul.Britton@jcu.edu.au, Phil.Schnieder@jcu.edu.au, Madoc.Sheehan@jcu.edu.au Keywords: Drying,
More informationSD-06AG Laboratory Scale Spray Dryer
SD-06AG Laboratory Scale Spray Dryer SD-06AG Laboratory Scale Spray Dryer INTRODUCTION The LabPlant SD-06AG Laboratory Scale Spray Dryer is the result of 30 years of continuous development in the field
More informationFrozen in Time. Operating Manual HSLS - 4. Manufacturers of Freeze Drying Machines and Vacuum Cold traps. Page 1
Frozen in Time Manufacturers of Freeze Drying Machines and Vacuum Cold traps Operating Manual HSLS - 4 Page 1 [Pick the date] Operating Manual HSLS-4 Order Number: Serial Number: In case of enquiries please
More informationLAARMANN CM 2500 / CM Power Cutting Mill. Superior Cutting Mills engineered for rapid reduction of large particles. Innovators in Solids
LAARMANN Power Cutting Mill CM 2500 / CM 4000 Superior Cutting Mills engineered for rapid reduction of large particles Rapid reduction of large particles from upt to 350mm down to 2 mm Quick and easy to
More informationVertical Centrifugal Coater VCC
DIOSNA Processing plants for laboratory and production Vertical Centrifugal Coater VCC Film Coating of Tablets. Efficient, Accurate, Fast. VCC. The Future of Coating DIOSNA Vertical Centrifugal Coater
More informationHygiene Rotary Filler & Capper. AFRB Series Servo Driven CNC Rotary Filler and Capper
M a c h i n e r y Hygiene Rotary Filler & Capper AFRB Series Servo Driven CNC Rotary Filler and Capper Hygiene Rotary Filler and Capper The Principle Function: The highly flexible Hygiene Rotary Filling
More informationStock Vessels for Improved Quality and Energy Savings
Innovative Mixing of 6%-20% Consistency Stock Vessels for Improved Quality and Energy Savings Marc R. Moseley Manager, Global Pulp & Paper Industry Philadelphia Mixing Solutions, Ltd. Dr. Wojtek Wyczalkowski
More informationDRUM DRYER CHEMICAL FOOD
DRUM DRYER CHEMICAL FOOD CONTENT 1. DESCRIPTIONS 1.1 Process 1.2 Equipment 1.2.1 The single drum dryer 1.2.2 The double drum dryer 1.2.3 The vacuum drum dryer 2. R&D - REALIZING THE FUTURE VISION 3. ENERGY
More informationGranulation Technology by Bohle. Bohle Fluid Bed System BFS I Bohle Uni Cone BUC I Compact Unit I High Shear GMA I Single Pot VMA
Granulation Technology by Bohle Bohle Fluid Bed System BFS I Bohle Uni Cone BUC I Compact Unit I High Shear GMA I Single Pot VMA Bohle Uni Cone BUC L.B. Bohle developed the Bohle Fluid Bed Systems with
More informationModeling Solids Dryers and Granulators with Aspen Plus V8
Modeling Solids Dryers and Granulators with Aspen Plus V8 Ajay Lakshmanan and Claus Reimers Product Management, AspenTech Hosted by: Julie Levine and Ron Beck, Product Marketing, AspenTech Solids Process
More informationENVIRONMENT CHEMICAL FOOD
ENVIRONMENT CHEMICAL FOOD Content 1. DESCRIPTIONS 1.1 Process 1.2 Equipment 1.2.1 Features 1.2.2 Convective versus contact drying 1.2.3 Residence time 1.3 Applications 1.4 Example projects 2. PILOT PLANT
More informationHeat Pump Assisted Drying - Freeze Drying Technology
Heat Pump Assisted Drying - Freeze Drying Technology Trygve M. Eikevik Professor Norwegian University of Science and Technology (NTNU) Department of Energy and Process Engineering E-mail: trygve.m.eikevik@ntnu.no
More informationSEED DRYING. Definitions 8/31/2017. Potential mechanisms involved in desiccation tolerance. Phases of Seed Development and Maturation
SEED DEVELOPMENT OF ORTHODOX vs RECALCITRANT (Review article, Farrant et. al., 1993) 8/31/2017 SEED DRYING ACQUISITION OF DESICCATION TOLERANCE IN SEEDS Definitions DESICCATION TOLERANCE: It is generally
More informationROTATION-PULSED FLUID BED SALT DRYER. Todor Djurkov
ROTATION-PULSED FLUID BED SALT DRYER Todor Djurkov University of Food Technologies, 26, Maritza Str. Plovdiv, Bulgaria, E-mail: todordj@plov.omega.bg Abstract Salt is one of the most popular spices in
More informationOVENS Forced Convection Ovens. Economy Forced Convection Ovens. Vacuum Ovens.
OVENS Forced Convection. Economy Forced Convection. Vacuum. Selection Guide Convection Forced [Mechanical] Economy Forced [Mechanical] Natural (Gravity) Economy Natural (Gravity) Operating Temp. Range
More informationSpecialized in the design and the tailor-made production of dryers, coolers and thermal processing equipment for industrial use.
Specialized in the design and the tailor-made production of dryers, coolers and thermal processing equipment for industrial use. Thermal processing solutions Ingetecsa supplies thermal processing solutions
More information