teaching old sensors new tricks

Transcription

1 the future of digital health & the role of sensors teaching old sensors new tricks Dr Chris Dawson 25 th March 2014 The Technology Partnership plc

2 an introduction to ttp - technology and product development services staff; engineering, electronics, software, physics - based in Cambridge, UK Dr Chris Dawson chris.dawson@ttp.com The Technology Partnership plc

3 ttp technology transfer thermal & fluidics ttp develops products for consumer, industrial, and life-science markets

4 Atlas io key functionality thermal - heated zones x3 - pcr heating rate 8C/s - pcr cooling rate 5C/s - thermal control ±1C - rate C in 6s fluidics - micro fluidic consumable - pneumatic ports x11 - pneumatic control ±10mbar electronics - electrochemical potentiostat - current measurements to 2nA - current compliance +/-10uA mechanics - precise consumable location - blister actuation x4 - force control 100 ±1N

5 ttp technology transfer battery & wireless ttp develops products for commercial, retail, and communications markets

6 ttp technology transfer piezo modules ttp develops components and sub-systems for consumer, industrial and medical

7 ttp technology inhalers to downstream sensing - emulsions for digital PCR - printing for cells and biomolecules - deposition techniques for cellular analysis - low cost disposable fluorescently activated FACS

8 ttp technology transfer high-speed DSP ttp develops components and sub-systems for consumer, industrial and medical

9 a new look at existing sensing pushing proven technologies into new areas The Technology Partnership plc

10 capacitive sensing touch & pen whiteboard touch sensing system for the latest generation of interactive whiteboards large active sensing area (several metres) 10 simultaneous tracking points

11 multi-touch sensing signal processing electronics modelling signal processing algorithms A X x C Y a c y B b d D transmit lines pulse signal picked up by receive lines at each node (8000 nodes) resulting capacitive charge set up at each node

12 multi-touch sensing large format medical printed conductive tracks on a polyester film (no expensive ITO) stray capacitance fields can detect presence additional layer can detect pressure doesn t require flat substrate and can be formed in 3D shapes

13 fluorescence lifetime low cost, high quality scattering cuvette in system increased system efficiency pulsed light source, nanosecond flash single or multi frequency excitation optimised optics cuvette and system direct time-domain data enables fluorescence decay detection lower cost light source (LED) enables low cost (~$10), very compact florescence lifetime detection systems

14 fluorescence lifetime lab demonstrator

15 new sensor technologies developing innovative sensing techniques The Technology Partnership plc

16 intravascular sensing imaging techniques new modalities in optics & ultrasound providing breakthroughs in performance, scale, size and cost for applications in medical imaging TTP ultrasound transducers Electronics Tx pulser HV amp Rx beam proc. VCA (TGC) LNA T/R switch Transducer

17 intravascular sensing integrated ultrasound - retrofitted ultrasound probe provides real time imaging during the surgical procedure - navigate to surgical site and monitor treatment - both cardio and peripheral peripheral arterial surgery: integrated imaging and debridement cardiac surgery: integrated imaging and ablation

18 intravascular sensing visualisation solution - imaging probe - electronics (amplification, T/R switch, filtering) - signal processing (filtering, Hilbert transform, circumferential deconvolution) - ablation plus control system - pullback and steering control system - catheter and guidewire construction - image analysis software (vein diameter, tissue type) - imaging system instrumentation and user interfaces surrounding bodily fluid underlying healthy tissue indentation formed by surgical tool lesion

19 coriolis mass flow sensor principle of operation piezoelectric actuation electromagnetic actuation obstructionless no bearings or probes low power low maintenance bi-directional sanitary, suitable for steam cleaning measurement of liquids, slurries, foams, gases

20 TTP coriolis sensor manufacturing for medical built using standard MEMs-type production techniques batch fabrication using laminated steel low cost (disposable) flow tube high sensitivity (~1g/hr) measurement of density and mass flow rate

21 RSS (dbm) RF breathing detection principle of operation measures capacitance of lungs as they fill and empty initial experiments performed using GHz frequency range patch antennas sensing solution based on a single adhesive patch antenna Time (s) traces of heart rate signal can be seen after full exhalation; able to pick out heart rate during this phase of the breathing cycle

22 RF breathing detection advantages operate through clothing lends itself to a low-power, low-cost solution unobtrusive, easy to apply, comfortable to wear wireless sensing and communications low cost gives potential for a disposable solution and infection control between patients possibility to use core technology to track patient within hospital

23 SonicSense acoustic gas sensor SonicSense uses ultrasonic actuation to make highly accurate measurements of the speed of sound through a gas the sensor response varies linearly to changes in the speed of sound through a gas mixture the speed of sound alters depending upon the gas type and operating pressure/density temperature compensation is applied

24 sensor output (arbitary units) sensor output (arbitary units) speed of sound measurement can be used to measure gas pressure, or where pressure is known to determine the composition of more complex gas mixtures through densities speed of sound (m/s) pressure (mbar) low cost in volume ($5-$10) low power consumption (~10 mw) so suitable for battery powered products good sensor response (linear, wide detection range, stable over time, immune to poisoning) robust, simple construction with long lifetime and no in-field calibration

25 wireless enabled sensing enabling data collection and analytics The Technology Partnership plc

26 wireless gas sensing flow & pressure monitoring biomimetic cilia hair thin to minimise impact on gas flow length adjustable to gather information about boundary layer or free flow existing pressure sensors: flexible wired links unreliable batteries limited life & require space sprung flexible support PZT force sensor new pressure sensing platform can offer: low mass wireless operation energy harvesting to eliminate battery operate in harsh environment

27 wireless condition monitoring animal stomach robust stomach sensor measures ph collar comms device contains gyroscope low power wireless comms transfers data to external monitoring station early warning of herd acidosis and corrective nutritional action high milk quality maintained, costs reduced detectable with simple sensors in difficult places Bayesian analysis can take sensor drift into consideration

28 TTP TouchCom data through touch - data transmission using the body - assert identity - transmit personal information - makes use of coded electric field - no interference between adjacent systems - simplifies set-up - access control - buildings - equipment - records - high speed, high security biometrics - biometric data transferred then validated

29 TouchCom medical applications - activation of equipment by authorised users and tracking of use - interaction with patients tracked and logged through contact - check operation of equipment with gloved hands or confirm continuous protection - natural, unobtrusive, quick, nothing to remember

30 strain measurement truly embedded battery-free wireless sensing: diffusion-proof metal encapsulation communication through 12 of flesh ability to interface to multivariable sensors protected digital communications compact size for implantation deep within the body benefits: monitoring of product performance research tool personalised medicine potential for closed loop feedback ultimately greater safety and efficacy, enhanced claims, competitive advantage

31 where to next? what is the future of sensing in healthcare? The Technology Partnership plc

32 sensing technologies future trends measuring new properties measuring in hard to reach places new sensing technologies increased dynamic range/broader spectrum bringing the lab to a integrated circuit near you measuring the same with less low cost embedded wireless sensing low power consumption/energy harvesting harsh environment capability enable new implementations multi-modal/multi-parameter allow disposable solutions low-cost data analytics