Controlled Environment Equipment Solutions for the Lab

Controlled Environment Equipment Solutions for the Lab Forma Stackable Orbital Shakers Analyze Detect Measure Control TM

Features and Technical Specifications Forma Stackable Orbital Shakers An Ideal Solution for Sensitive and Hard Shake Applications Thermo Electron Corporation s newly designed Forma Stackable Orbital Shakers will meet the challenges of your sensitive cultures as well as your traditional hard shake bacterial cultures. Our units are designed for high volume scale-up cell culture, process optimization research at different temperatures and speeds (i.e., different growing environments), and high volume research conducted in labs with limited space and multiple environments or users. Applications involving eukaryotic cells and other slower growing cultures are more sensitive to contamination than traditional bacterial cultures. We help you keep the chamber clean and avoid cross contamination by providing a HEPA filtration system, one-piece interior, and coved corners. A notably uniform temperature (±0.3C) promotes the vitality of your cultures. And as for hardy bacterial cultures, these stable, space saving, stackable shakers have a wide speed range (usable even when units are stacked and bolted three high) that is ideal for your vigorous hard shake applications. Our expanded orbital shaker product line now includes stackable models in both refrigerated and incubated configurations. Incubated Model 440 (441) and Refrigerated Model 490 (491) are specially designed for laboratory professionals seeking high capacity shakers but lacking the floor space to accommodate multiple large console models. All models feature an insulated, fold-down door with wide-view window for high visibility. These modular shakers may be stacked up to three units high for three times the capacity of a console shaker in nearly the same footprint. 2 Models 490 (491) shown with optional accessories AIRFLOW Forced air circulation system and built-in High Efficiency Particulate Air (HEPA) filter for temperature uniformity and reduced risk of cross contamination make these shakers ideal for eukaryotic cell culture. HEPA filter is rated a minimum 95% efficient at 0.3 microns for entrapment of extraneous airborne particulates. FOAMED-IN-PLACE POLYURETHANE ;;;; INSULATION ;; ;;; ; ;; ; ;;; ; ;;; ; ;;; ; ;; ;; HEPA FILTER DRAIN AIRFLOW BLOWER

Uniquely Designed Our versatile shakers include many unique features that set these stackable shakers apart from others, save time, simplify your work, and provide peace-ofmind performance. World s most durable and dynamically balanced orbital shaker mechanism (U.S. Patent 5,558,437) ensures smooth operation for optimum oxygenation and nutrient mixing, reduced cell clumping, and prevention of splashing and flask wetting. Triple counterbalanced mechanism provides optimum handling of full or unbalanced loads, regardless of flask placement. Heavy-duty, eccentric drive mechanism allows extended speed ranges from 25 to 400 RPM, ±1 RPM with minimal vibration, even when shakers are stacked three-high. Slide-out platform features a large mounting surface area and is secured to ensure a smooth, stable motion. Platform motion is continuously monitored independently of motor operation for added protection. Heavy-duty, permanently lubricated bearings provide long life. Cool running, brushless, 1/3 HP, DC motor ensures continuous maintenance-free operation. Temperature uniformity of ±0.3C makes these units ideal for both bacterial and mammalian cultures. Horizontal HEPA Filter Airflow design (U.S. Patent 5,577,837) ensures that air inside the unit remains clean and reduces cross contamination so culturing conditions are improved. A 2 year or 12,000 hour use warranty, whichever comes later, on parts and labor reinforces our commitment to you. Unit production lifetime warranty is on the shaker mechanism, parts only. Sturdy, Functional, and Convenient Forma Stackable Orbital Shakers are built to withstand the rigors of constant use as well as the stresses caused by stop-and-go operation. Fold-down door with ergonomically designed door handle, large quick-release base (included), and dedicated or universal slide-out shaker platform provide convenient access to your product, regardless of its position on the 29.5" x 18" (74.9cm x 45.7cm) platform. Universal and dedicated platforms are ordered separately. Flip-down handle/latch on the quick-release base prevents the shaker from running if the universal or dedicated platform is not secured. Easy-to-clean platforms are constructed of 5/16", heavy-duty, brushed anodized aluminum, which does not chip or rust. Heavy-gauge cold-rolled steel exterior is designed to safely support units stacked three high. Top platform height is under 61.0" (154.9cm) when units are stacked three high, ensuring ease of use and convenient accessibility. Crevice-free Type 304 stainless steel interior with coved corners and built-in drain keeps spills within the work area and promotes easy cleaning. Interior is tall enough to hold 2 liter Erlenmeyer flasks. Interior xenon light with switch improves visibility. Shaker door features a magnetic gasket for a tight seal, pneumatic dampers for smooth controlled opening, and hinges with counterbalance springs to ease door closing. Electronic components and HEPA filter are easily accessed from the front of the unit, eliminating the need to move the shaker during regular maintenance or service. 3 PLATFORM Slide-out system provides access to electronic components, ensuring easy maintenance. Convenient access to the HEPA filter permits quick filter changes. INTERIOR Stainless steel interior has coved corners for easy cleaning.

Features and Technical Specifications Forma Stackable Orbital Shakers Easy to Program and Monitor Microprocessor Control/Monitoring System allows easy icon-based programming and monitoring of the time, speed, and temperature setpoints and runpoints. Two-line, 40 character message/information center provides continuous updates of setpoint and actual time, speed, and temperature. Runpoints and setpoints are displayed simultaneously for convenient run cycle monitoring. Backlit display ensures message visibility in low and bright light conditions. Audible/visual over and undertemperature tracking alarms ensure product protection. A separate adjustable overtemperature safety alarm with independent probe provides additional backup on heated units. Refrigerated units also feature an undertemperature safety alarm. All microprocessor functions can be calibrated easily through the keypad. Sealed control panel minimizes concern about accidental spills. Audible/visual, high/low RPM tracking alarms alert you if speed deviations occur. Alarms can be silenced temporarily and ring back as a reminder of unresolved alarm conditions. Non-volatile memory saves settings during a power outage and automatically restarts the unit after power is restored. Microprocessor tracks total accumulated time on motor and drive systems. Controlled acceleration circuitry provides smooth start-up and stopping to eliminate splashing and wetting of flask closures. RS-232 port is standard on all models and permits computer interface and monitoring of time, speed, and temperature. For long-term documentation, an optional freestanding chart recorder is available. Standard remote alarm contacts allow convenient monitoring of alarm conditions from another location. Backlit Display Two-line, 40 character, LCD, alphanumeric display is a complete message/information center for actual (run) and setpoint parameters, and alarm condition messages. Audible/Visual Alarm Indicator Up and Down Arrow Keys During programming, these keys increase and decrease the time, speed, and temperature values. Start Starts the shaker s operation 4 Alarm Silence Time, Speed, and Temp C Icons/buttons allow easy programming of set parameters. Time: Counts upward, showing total operating hours and minutes for the run Stop Causes the shaker to stop operating Speed: Displays the actual platform speed (RPM) Temp C: Displays the actual temperature inside the cabinet

Specifications Models Incubated........... 440 (441) Refrigerated......... 490 (491) RPM Speed Range........ 25-400 RPM Accuracy........... ±1 RPM Orbital Motion....... 1.0" (2.5cm) Indicator............ LCD, readable in 1 RPM increments Time Range.............. Continuous operation (hold) or timed operation from 1 minute up to 199 hours and 59 minutes Indicator............ LCD, readable in 1 minute increments, counts up for continuous operation (hold) or counts down for timed operation Temperature Range.............. 440 (441): 10C above ambient to 60C (140F) 490 (491): 5C (41F) or 20C below ambient to 60C (140F) Control............. ±0.15C Uniformity.......... ±0.3C (in flask) Indicator............ LCD, readable in 0.1C increments Platform Size............... 29.5" x 18.0" (74.9cm x 45.7cm) Exterior Dimensions Width (440/441)...... 46.5" (118.1cm) Width (490/491)...... 56.5" (143.5cm) Height............. 25.0" (63.5cm) F-B (door closed)..... 33.3" (84.6cm) F-B (door open)....... 46.6" (118.4cm) Interior Dimensions Width.............. 33.4" (84.8cm) Height............. 11.8" (30.0cm) F-B................ 23.8" (60.5cm) Electrical 440................ 120V, 60 Hz, 6.4 FLA (Operating range 108-132V) 490................ 120V, 60 Hz, 9.0 FLA (Operating range 108-132V) 441................ 230V, 50 Hz, 3.0 FLA (Operating range 207-253V) 491................ 230V, 50 Hz, 4.5 FLA (Operating range 207-253V) Plug 120V Models........ NEMA 5-15P 230V Models........ CEE 7/7 Plug Weight Net 440 (441).......... 545 lbs. (247.2 kg) 490 (491).......... 610 lbs. (276.7 kg) Shipping (Motor) 440 (441).......... 658 lbs. (298.5 kg) 490 (491).......... 723 lbs. (328.0 kg) Continuing research and improvements may result in specification changes at any time. Specifications are based on nominal voltages of 120V or 230V in ambients of 22C to 25C (71.6F to 77F). Performance is plus or minus the least significant digit unless otherwise specified. 5 OTHER ORBITAL SHAKERS In addition to our line of stackable orbital shakers, we offer orbital shakers in tabletop and console models. Contact us for details.

Features and Technical Specifications Accessories for Stackable Shakers We offer a wide variety of accessories to increase your shaker s versatility and usefulness. Universal platforms, clips, and stands are described here. Visit www.thermo.com/forma, or refer to our Orbital Shakers (Tabletops and Consoles) brochure to learn about our complete line of accessories (e.g., test tube rack holders and racks, microplate rack inserts, vial/tube inserts, utility trays). Stock No. Description 194222 Stand for One Stackable Shaker, 45.5"W x 29.6"H x 35.3"F-B (115.6cm x 75.2cm x 89.7cm); 30.6" (77.7cm) maximum height with leveling feet extended 194223 Stand for Two Stackable Shakers, 45.5"W x 11.8"H x 30.5"F-B (115.6cm x 30.0cm x 77.5cm); 12.8" (32.5cm) maximum height with leveling feet extended Clips for Universal Platform Stock No. Description 236010 25ml Erlenmeyer Flask Clip 236011 50ml Erlenmeyer Flask Clip 236012 125ml Erlenmeyer Flask Clip 236013 250/300ml Erlenmeyer Flask Clip 236014 500ml Erlenmeyer Flask Clip 236015 1l Erlenmeyer Flask Clip 236016 2l Erlenmeyer Flask Clip 236099 Flask Clip Starter Kit, includes (2) 236010, (2) 236011, (2) 236012, (4) 236013, (4) 236014, (2) 236015, (2) 236016, and (1) 194046 236019 2800ml Fernbach Flask Clip 236025 Microplate Clip 300349 Adhesive Flask Mat (1 roll), 1.6" x 16.4' 194046 Replacement Screws. (50) #10-24 x 5/16" Countersink Phillips Head Screws for Clips; (12) 1/4-20 x 3/4" Countersink Flat Head Socket Screws for Platforms 194224 Door Glass Cover (prevents light from entering window) Dedicated Platforms (complete with clips) 201126 0-100C, 6", 7 Day Chart Recorder, 115V, 60 Hz For All Models Platform Size: 29.5" x 18.0" (74.9cm x 45.7cm) 201127 0-100C, 6", 7 Day Chart Recorder, 220V, 50 Hz 6000440 Installation and Operational Qualification (IQ/OQ), includes printed copies and an MS Windows -compatible document disk and detailed checklists Universal Platform (without clips) For All Models Platform Size: 29.5" x 18.0" (74.9cm x 45.7cm) Platform Number: 238061 Maximum Flask Capacity Flask Capacity Maximum No. of Flasks Platform No. 25ml............... 91............ 238066 50ml............... 91............ 238067 125ml.............. 40............ 238068 250/300m........... 30............ 238069 250/300ml........... 40............ 238070 500ml.............. 24............ 238071 1l.................. 15............ 238072 2l.................. 12............ 238073 2800ml.............. 6............. 238074 Maximum Flask Capacity 25ml............ 91 50ml............ 91 125ml........... 39 250/300ml........ 30 500ml........... 24 1l............... 12 2l............... 11 2800ml........... 6 Microplates*...... 18 6 Platform also accommodates clips and accessories manufactured by other companies. *Microplates can be stacked for greater capacity. STANDS Shaker stand No. 194222 and 194223 shown with Model 440 (441) Stackable Shakers

Recognized Worldwide for Quality, Safety, and Service For your personal safety and product protection, our orbital shakers are manufactured to conform with our Continual Improvement guidelines. Our commitment to you is reinforced by our adherence to world quality and safety standards. cul and UL Listing and the CE Mark cul and UL Listing and the CE Mark attest to the electrical and mechanical safety of our orbital shakers. Unit construction and electrical characteristics comply with Underwriters Laboratories, CSA International, and International Electrotechnical Commission requirements. The orbital shakers undergo stringent testing before they carry the UL and CE markings. Application of the CE Mark also means that the equipment has been tested for compliance with international requirements related to emission of, and susceptibility to, RF energy and electrostatic discharge. Copies of UL and CE documentation are available for compliance verification. ISO 9001: A Commitment to Excellence As an innovative, global leader, we continue the pursuit of excellence by maintaining ISO 9001 registration. This advanced quality system reinforces our commitment to provide the highest quality products available. The ISO 9000 series is a set of international requirements for establishing and maintaining quality management systems. Continued compliance is assured by ongoing internal audits and periodic audits by the assessing agency. We are proud to be ISO 9001 registered. Warranty Protection We confidently back our stackable orbital shakers with a 2 year or 12,000 hour use warranty, whichever comes later, on the entire unit, including parts and labor. The shaker mechanism, parts only, has a Unit Production Lifetime Warranty. Call our Services Department or your local international distributor for details. Unmatched Laboratory Services Our support continues after the point-of-purchase. A worldwide network is ready to support your specific and unique needs. Some of the laboratory services offered include the following: Consultation Extended Warranties Preventive Maintenance Agreements Replacement Parts Repair Services Contact Us Training Calibration Installation Proof of Performance Qualification/Validation Datalogger Systems Our Sales Support Department (toll free 866-9- THERMO) is available from 8:00 a.m. to 6:00 p.m. (ET). International customers may call 740-373-4763 for Sales Support from 8:00 a.m. to 4:30 p.m. (ET). For details about our laboratory services, contact the Services Department at 888-213-1790 (toll free) from 8:00 a.m. to 6:00 p.m. (ET) or e-mail help@thermolabservices.com. International customers should contact their authorized local distributor for information about available services. 7 UNIVERSAL PLATFORM Quick release platform base beneath universal platform No. 238061 shown with optional adhesive flask mat, flasks, and flask clips CLIPS FOR UNIVERSAL PLATFORM Erlenmeyer flask clips and a microplate clip for stackable orbital shaker platforms DEDICATED PLATFORM Platform No. 238073 includes (12) 2 liter flask clips.

People of Science Working with People of Science A Leader in Controlled Environment Equipment Whether you are storing, preparing, culturing, or analyzing samples, Thermo has the research tools you depend on to succeed in the lab. We have been providing high quality, reliable controlled environment laboratory products for a wide variety of clinical, educational, biotechnological, pharmaceutical, and industrial applications for more than 50 years. We offer the following: Forma Cell Culture Incubators Forma In Vitro Fertilization (IVF) Incubators and CryoMed Controlled Rate Freezers Forma Environmental Chambers Forma Ultra-Low Temperature Freezers Forma Laminar Airflow Equipment Forma Biological Safety Cabinets Forma Cryopreservation Equipment Forma Blood Bank Equipment Forma Circulating Baths Forma Monitor/Alarm System Forma Orbital Shakers Forma Programmable Centrifuges Forma Lab Washers/Dryers Forma Lab Refrigerators Forma Lab Freezers Forma Chromatography Refrigerators Custom-Designed Equipment Laboratory Services One Convenient Source, Total Solutions Thermo s expertise extends beyond controlled environment equipment. In fact, you may be surprised by the breadth of products and services we offer. Our life and laboratory sciences and services, optical technologies, measurement and control, turnkey operations, and even capital equipment financing specialists are eager to share their knowledge and work as your partner...for life. The benefit? We re people of science working with people of science. And you will quickly discover the value of one convenient source providing total solutions tailored to your specific needs. About Thermo Thermo provides scientific instruments, equipment, software, and solutions that help laboratory and industrial customers advance scientific knowledge, enable drug discovery, improve manufacturing processes, and protect people and the environment. With annual revenue exceeding $2 billion, Thermo is a global leader employing 11,000 people in 30 countries worldwide. The company is based in Waltham, Massachusetts. 2003 Thermo Electron Corporation. All rights reserved. Thermo Electron Corporation, question everything, and Analyze. Detect. Measure. Control are trademarks of Thermo Electron Corporation. Forma and CryoMed are registered trademarks of Thermo Forma. Windows is a registered trademark of Microsoft Corporation. Rev. 0, 03/03 10M Controlled Environment Equipment P.O. Box 649 Marietta, OH 45750 740-373-4763 Fax: 740-373-6770 Toll Free USA and Canada 866-984-3766 www.thermo.com/forma