ANTAGON. Reg. No. L 8842, Act/Wet No/Nr 36 Van/Of 1947 FRAC FUNGICIDE GROUP CODE M7 FRAC SWAMDODER GROEPKODE. Active ingredient/aktiewe bestanddeel:

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ANTAGON Reg. No. L 8842, Act/Wet No/Nr 36 Van/Of 1947 A suspension concentrate, local acting systemic fungicide with residual effect on crops as listed. n Suspensie konsentraat, lokale sistemiese swamdoder met residuele aktiwiteit op gewasse soos aangedui. FRAC FUNGICIDE GROUP CODE M7 FRAC SWAMDODER GROEPKODE Active ingredient/aktiewe bestanddeel: Dodine (guanidine) 400 g/l Contents 1 l Inhoud REGISTRATION HOLDER / REGISTRASIEHOUER: Meridian Agrochemical Company (Pty) Ltd / (Edms) Bpk Reg. No. 2000/010819/07 PO Box / Posbus 436 Modderfontein 1645 South Africa / Suid Afrika Batch No. Date of manufacture. Lotnommer Datum van vervaardiging UN 3082 SK A DELIK/HA R M FUL

WARNINGS Allow the following number of days between last treatment and harvest: Apples, pears and quinces......14 days IMPORTANT: The recommended withholding period between last application and harvest meets local residue requirements, but may not meet export requirements. Handle with caution Harmful if swallowed, inhaled or absorbed through skin. In case of poisoning, promptly contact a physician and show this label. Keep out of reach of children, uninformed persons and animals. May damage eyes. May cause irritation of skin as well as of nose and throat membranes. Re-entry Do not enter treated area until spray deposit has dried unless wearing protective clothing. Store in original or marked container, safely away from food and feeds. Toxic to fish and very toxic to other aquatic organisms. Antagon has been tested on some of the most important commercial cultivars without any phyto toxic effects. More susceptible cultivars may be released in future, which need to be tested; for this apply Antagon to a limited test area before commercial applications are made. Although this remedy has been extensively tested under a large variety of conditions, the registration holder does not warrant that it will be effective under all conditions. The activity and effect thereof may be affected by factors such as abnormal soil, climatic and storage conditions, quality of dilution water, compatibility with other substances not indicated on the label and the occurrence of resistance of the disease against the remedy, as well as by the method, time and accuracy of application. The registration holder furthermore does not accept responsibility for damage to crops, vegetation, the environment or harm to man or animal, or for lack of performance of the remedy concerned due to failure by the user to follow the label instructions, or to the occurrence of conditions which could not have been foreseen in terms of the registration. Consult the supplier in the event of any uncertainty. PRECAUTIONS Do not inhale fumes or spray mist. Avoid skin and eye contact by wearing protective clothing when mixing the product. Should eye contact occur, flush with plenty of water and get medical attention if necessary. For tank mixing with products in fungicide group M, refer to individual labels. Wash with soap and water after use and accidental skin contact as well as contaminated clothing. Do not eat, drink or smoke while mixing or applying the product or before washing hands and face. Prevent contamination of food, feeds, drinking water and eating utensils. Avoid drift of spray onto other crops, grazing, rivers, dams and areas not under treatment. Clean applicator after use. Dispose of rinsate where it will not contaminate crops, grazing, rivers, dams and boreholes. Rinse empty container three times with a volume of water equal to a minimum of 10% of that of the container. Add the rinsings to the contents of the spray tank before destroying the empty container by perforation and flattening. Do not use the empty container for any other purpose. 2

FIRST AID TREATMENT Inhalation may cause respiration difficulty and irritation to eyes. Eyes Ingestion Inhalation Skin : Wash immediately with large amounts of water. If irritation develops consult a physician. : Do not induce vomiting. If conscious, give one or two glasses of water to drink and see a physician immediately. : Remove patient to fresh air immediately : Remove contaminated clothing. Do not rub skin. Wash affected area immediately with soap and large amounts of water. If irritation develops consult a physician. NOTE TO PHYSICIAN Treat supportively and symptomatically. RESISTANCE WARNING For resistance management, Antagon is a group code M7 fungicide. Any disease population may contain individuals naturally resistant to Antagon and other group code M7 fungicides. The resistant individuals can eventually dominate the disease population if these fungicides are used repeatedly. These resistant diseases may not be controlled by Antagon or any other group code M7 fungicide. To delay fungicide resistance: Avoid exclusive repeated use of fungicides from the same fungicide group code. Do not exceed 3 applications per growing season. Alternate or tank mix with registered products from different fungicide group codes. A spray programme of mixtures or alternations with remedies with a different mode of action may delay resistant strain build-up. Integrate other control methods (chemical, cultural, biological) into disease control programmes. Since the occurrence of resistance cannot be forecast, users are advised to keep treated crops under close observation. If treatment is not effective following the use of Antagon as recommended, a resistant strain may be present. If a resistant strain is positively identified, consideration should be given to prompt use of a fungicide with a different mode of action for which there is no record of resistance to the relevant disease. For specific information on resistance management, contact the registration holder of this product. USE RESTRICTIONS The uptake and activity of systemic compounds can be reduced when crops are under severe drought and/or nutrient stress conditions. Therefore, do not apply Antagon under such conditions. Spray programmes with Antagon should commence before disease/s become established. Do not apply Antagon to any crop or situation not mentioned in this instruction leaflet. Only apply Antagon using an accurate and safe application technique. If Antagon is used in a tank mix with other recommended products, consideration should be given to the restrictions of those respective products. 3

DIRECTIONS FOR USE Use only as directed. Under slow drying weather conditions, there is a probability that the product may cause fruit russetting with special mention to Golden Delicious, Granny Smith and Packham s Triumph. Therefore, it is advisable that the product only be used during the pre-blossom stage on these cultivars. Once the fungicide has dried, it has reasonable rain fastness. After precipitation of 80mm or more, it can be expected that efficacy can be significantly reduced and re-spraying may be needed. MIXING INSTRUCTIONS Half-fill the spray tank with suitable water, then add the required amount of Antagon to the water in the tank while agitating. Fill the spray tank to the desired volume. Do not use brackish water. Should tank mixtures with other products be made, follow the respective manufacturers label recommendations. Where wettable powder formulations are used in combination with Antagon, a slurry should firstly be made with the powder and some water, mixed into the spray tank and finally the Antagon can be added. Tank mixtures must be sprayed out immediately and not allowed to stand in the spray tank. Spraying equipment must be thoroughly flushed out at the end of the spraying operation. COMPATIBILITY The compatibility of Antagon with other products depends on the formulations of the respective products as well as the quality of the spray water to be used. As formulations change from time to time it is recommended that a physical compatibility test be done prior to the tank mixture being made. Antagon is not compatible with lime, chlorbenzilate, oils, azinphos-methyl and diazinon. APPLICATION METHODS Ensure that the equipment is correctly calibrated and is checked regularly during application to ensure even and accurate application. Only clean water should be used. RECOMMENDATIONS Apples Scab (Venturia inaequalis) Pears Scab (Venturia pirina) Quinces Black spot Pre- & post blossom 120 ml /100 l water. Pre- and post-blossom 120 ml /100 l water Apply the first spray at green-tip (20 tips / tree) and repeat at intervals of 7 to 10 days. Extend intervals to 14 days, 2 weeks after full bloom. Stop application towards beginning of December. Continue spraying in cases of incomplete control and prolonged wet weather. Do not exceed 3 applications per growing season. Apply the first spray at green-tip (20 tips / tree) and repeat at intervals of 7 to 10 days. Extend intervals to 14 days, 2 weeks after full bloom. Stop application towards beginning of December. Continue spraying in cases of incomplete control and prolonged wet weather. Do not exceed 3 applications per season. The Antagon broad spectrum fungicide combinations may be used curatively to supplement a preventative contact fungicide spray programme. Curative applications are only recommended when adequate and reliable disease prediction systems are available. Treatment should be made within 4 days of the onset of an infection period. 4

WAARSKUWINGS Laat die volgende aantal dae toe tussen laaste behandeling en oes: Appels, pere en kwepers........................................................................ 14 dae BELANGRIK: Die aanbevole onthoudingsperiode tussen laaste toediening en oes voldoen aan die vereistes vir plaaslike residuvlakke maar mag dalk nie voldoen aan vereistes vir uitvoer nie. Hanteer versigtig Skadelik indien ingesluk, ingeasem of deur vel geabsorbeer word. In geval van vergiftiging, kontak onmiddelik 'n geneesheer en verwys na hierdie etiket. Hou buite bereik van kinders, oningeligte persone en diere. Mag oë beskadig. Mag vel en membrane van die neus en keel irriteer. Herbetreding - Moet nie behandelde gebied betree alvorens die spuitneerslag droog is nie, tensy beskermende oorklere gedra word. Berg in die oorspronklike of 'n gemerkte houer, weg van voedsel en voer af. Giftig vir visse en baie giftig vir ander waterorganismes. Antagon is getoets op sommige van die belangrikste kommersiële kultivars sonder enige fito- toksiese effekte. Meer vatbare kultivars kan in die toekoms vrygestel word, wat nodig het om getoets te word, dis van toepassing dat Antagon in 'n beperkte area getoets word voordat kommersiële toepassings gemaak word. Alhoewel hierdie middel omvattend onder 'n groot verskeidenheid toestande getoets is, waarborg die registrasiehouer nie dat dit onder alle toestande doeltreffend sal wees nie. Die werking en effek daarvan beïnvloed kan word deur faktore soos abnormale grond-, klimaats-en bergingstoestande, kwaliteit van verdunningswater, verenigbaarheid met ander stowwe wat nie op die etiket aangedui en die voorkoms van weerstand van die siekte teen die betrokke middel, sowel as deur die metode, tyd en akkuraatheid van toediening. Die registrasiehouer aanvaar geen verantwoordelikheid vir skade aan gewasse, plantegroei, die omgewing of vir nadelige effek op mens of dier of vir 'n gebrek aan prestasie van die betrokke middel betrokke as gevolg van versuim van die gebruiker om die etiketaanwysings na te volg, of aan die voorkoms van toestande wat nie kragtens die registrasie voorsien. Raadpleeg die verskaffer in die geval van enige onsekerheid. VOORSORGMAATREËLS Moenie dampe of spuitnewel inasem nie. Vermy vel-en oogkontak deur beskermende klere te dra wanneer die produk gemeng word. Indien oog kontak plaasvind, spoel met baie water en kry mediese aandag indien nodig. Vir tenkmengsels wat gemaak word met produkte in swamdoder M, verwys na individuele etikette. Was met seep en water na gebruik,toevallige velkontak sowel as besoedelde klere. Moet nie eet, drink of rook tydens vermenging of toediening van die produk of voordat hande en gesig gewas is nie. Voorkom besoedeling van voedsel, voer, drinkwater en eetgerei. Vermy wegdrywing van spuitnewel na ander gewasse, weiding, riviere, damme en areas wat nie onder behandeling is nie. Maak toedieningsapparaat deeglik skoon na gebruik. Raak ontslae van spoelwater waar dit nie gewasse, weiding, riviere, damme en boorgate sal besoedel nie. Spoel leë houer drie keer uit met 'n volume water gelykstaande aan' n minimum van 10% van die inhoud van die houer. Gooi die spoelwater uit by die inhoud van die spuittenk voordat leë houer vernietig word deur gate in dit te maak en plat te slaan. Moet nie die leë houer vir enige ander doeleindes gebruik nie. 5

NOODHULP BEHANDELING Inaseming kan asemhaling probleme en irritasie aan oë veroorsaak. Oë Ingesluk Inaseming Vel : Was onmiddellik uit met groot hoeveelhede water. Indien irritasie ontwikkel raadpleeg 'n geneesheer. : Moenie braking induseer nie. Indien nog by bewussyn, gee een of twee glase water om te drink en sien onmiddellik 'n geneesheer. : Verwyder die pasiënt onmiddellik na vars lug : Verwyder besoedelde klere. Moet nie die vel vryf nie. Was vel direk geraak met seep en groot hoeveelhede water. Indien irritasie ontwikkel, raadpleeg 'n geneesheer. NOTA AAN GENEESHEER Behandel ondersteunend en simptomaties. WEERSTANDSWAARSKUWING Vir weerstand, Antagon is 'n groep kode M7 swamdoder. Enige siekte bevolking mag individue insluit wat 'n natuurlike weerstand teen Antagon of enige ander groepkode M7 swamdoder het. Die weerstandbiedende individue kan uiteindelik die siekte bevolking oorheers indien hierdie swamdoders herhaaldelik aangewend word. Hierdie weerstandbiedende siektes mag nie beheer word deur Antagon of enige ander groepkode M7 swamdoder. Om swamdoder weerstand te vertraag: Vermy die eksklusiewe herhaaldelike gebruik van swamdoders in dieselfde swamdoder groepkode. Moet nie meer as 3 toedienings per groeiseisoen toedien. Wissel af met, of gebruik tenkmengsels van, geregistreerde produkte uit verskillende swamdoder groepkodes. 'n Spuitprogram van mengsels of afwisselings met middels met' n ander modus van aksie, kan die opbou van weerstandbiedende ras vertraag. Integreer ander beheermaatreëls (chemies, verbouing, biologies) in siekte beheer programme. Aangesien die voorkoms van weerstand nie voorspel kan word nie, word gebruikers aangeraai om behandelde gewasse onder noukeurige waarneming te hou. Indien behandeling nie effektief is nie as gevolg van die gebruik van Antagon soos aanbeveel, mag 'n weerstandbiedende ras teenwoordig wees. As 'n weerstandbiedende ras positief geïdentifiseer word, moet oorweging geskenk word om die gebruik van' n swamdoder te vinnig met 'n ander modus van aksie, waarvoor daar geen rekord van weerstand teen die betrokke siektes is nie. Vir spesifieke inligting oor weerstandsbestuur, kontak die registrasiehouer van hierdie produk. GEBRUIKSBEPERKINGS Die opname en aktiwiteit van sistemiese middels kan verlaag word wanneer gewasse onder ernstige droogte en / of voedingstof stresstoestande is. Daarom is dit nie van toepassing om Antagon onder sulke omstandighede te gebruik nie. Spuit programme met Antagon moet aanvang neem voordat die siekte / s gevestig is. Moet nie Antagon aan enige gewas of situasie wat nie genoem word in hierdie instruksie pamflet gebruik nie. Gebruik Antagon slegs met behulp van 'n akkurate en betroubare toepassing tegniek. As Antagon gebruik word in 'n tenkmengsel met ander aanbevole produkte, moet oorweging geskenk word aan die beperkings van dié onderskeie produkte. 6

GEBRUIKSAANWYSINGS Gebruik slegs soos aangedui. Onder stadige drogings weerstoestande, is daar' n waarskynlikheid dat die produk kan veroorsaak dat die vrugte russetting met spesiale vermelding van Golden Delicious, Granny Smith en Packham's Triumph. Daarom, is dit raadsaam dat die produk slegs gebruik word tydens die voorblom stadium op hierdie kultivars. Sodra die swamdoder droog is, het dit 'n redelike reën vastheid. Na neerslag van 80mm of meer, kan dit verwag word dat die effektiwiteit aansienlik kan verminder word en weer-bespuiting mag nodig wees. MENGINSTRUKSIES Maak die spuittenk halfvol met geskikte water en voeg dan die verlangde hoeveelheid Antagon by die water in die tenk terwyl dit geroer word. Vul die spuittenk tot die verlangde volume. Moet nie brakwater gebruik nie. Indien tenkmengsels met ander produkte gemaak word, volg die onderskeie vervaardigers se etiket aanbevelings. Waar benatbare poeier formulerings in kombinasie met Antagon gebruik word, moet 'n flodder in die eerste plek gemaak word met die poeier en' n bietjie water in die spuittenk en uiteindelik kan die Antagon bygevoeg word. Tenkmengsels moet onmiddellik uitgespuit word en nie toegelaat word om in die spuittenk te staan nie. Spuittoerusting moet deeglik gespoel word aan die einde van die toediening. VERENIGBAARHEID Die verenigbaarheid van Antagon met ander produkte hang af aan die formulerings van die onderskeie produkte asook die kwaliteit van die spuitwater wat gebruik is. Aangesien formulasies van tyd tot tyd verander, word dit aanbeveel dat 'n fisiese verenigbaarheidstoets gedoen word voor die tenkmengsel gemaak word. Antagon is nie versoenbaar met kalk chlorbenzilate, olies, azinfos-metiel en diazinon nie. Toedieningsmetodes Maak seker dat die toerusting korrek gekalibreer is en gereeld nagegaan word tydens toediening om egalige en akkurate toediening te verseker. Slegs skoon water moet gebruik word. AANBEVELINGS Appels Skurfsiekte (Venturia inaequalis) Pere Skurfsiekte (Venturia pirina) Kwepers Swartvlek Voor- & na blom 120 ml/100 l water. Voor- en nablom 120 ml/100 l water Dien die eerste bespuiting toe by die groen-tip (20 / boom) stadium en herhaal met tussenposes van 7 tot 10 dae. Brei intervalle uit na 14 dae, 2 weke na volblom. Stop die toedienin g voor die begin van Desember. Gaan voort met bespuiting in die geval van onvolledige beheer en langdurige nat weer. Moet nie meer as 3 toedienings per groeiseisoen toedien nie. Dien die eerste bespuiting toe by die groen-tip (20 / boom) stadium en herhaal met tussenposes van 7 tot 10 dae. Brei intervalle uit na 14 dae, 2 weke na volblom. Stop die toediening voor die begin van Desember. Gaan voort met bespuiting in die geval van onvolledige beheer en langdurige nat weer. Moet nie meer as 3 toedienings per seisoen toedien nie. Die Antagon breë spektrum swamdoder kombinasies kan curatief gebruik word om 'n voorkomende kontak aan te vul in n swamdoder spuitprogram. Kuratiewe aansoeke word slegs aanbeveel wanneer voldoende en betroubare siekte voorspelling stelsels beskikbaar is. 7

Behandeling moet gedoen word binne 4 dae na die aanvang van 'n infeksie periode 8