Project Description Clinical Research Building (CRB) Animal Area Renovation

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Table of Contents INTRODUCTION... 3 PROJECT OVERVIEW... 4 CONSTRUCTION SYSTEMS AND ASSEMBLIES... 10 SPECIAL ISSUES AND CONSIDERATIONS... 19 PRODUCTS... 20 Issued: June 22, 2012 1 OF 24

Issued: June 22, 2012 2 OF 24

INTRODUCTION 1.01 DOCUMENT INTENT A. This document supplements the Owner s Design Guideline Elements with initial design concepts that are specific to this proposed project. Design Guideline Elements, Master Construction Specifications, and Supplemental Resources (AutoCAD Standards, Interior Finishes Standards, Installation Details, HVAC Control Contract Document Requirements, and other referenced standards) are all combined under the heading "Owner's Design Guidelines". B. Refer to Owner s Design Guideline Elements A though G and Element Z for technical design criteria related to general building components, requirements for preparation of Project Manuals, and for additional MD Anderson requirements applicable to this Project. C. Refer to the Owner s Master Construction Specifications for product and construction execution requirements. Owner s Master Construction Specifications are available online at: http://www2.mdanderson.org/depts/cpm/standards/specs.html D. Supplemental Resources are inherent to the Owner's Design Guidelines and supplement the Master Construction Specifications and Design Guideline Elements. These Supplemental Resources are available online at: http://www2.mdanderson.org/depts/cpm/standards/supp.html 1. In addition to the Design Guideline Elements, MD Anderson maintains two documents referenced under Supplemental Resources that contain design guidelines specific to small animal vivarium. In areas such as piping, telecommunications, and security, there Issued: June 22, 2012 3 OF 24

may be an overlap of requirements between the following standards and the Design Guideline Elements. The AE should refer to the Design Guideline Elements for the most current requirements. 2. Small animal vivarium standards include: a. Design Standards for Small Animals (Rodents) Vivarium b. MD Anderson Noise Vibration and Ultrasound Design Guide PROJECT OVERVIEW 1.02 PROJECT OBJECTIVES A. This project will renovate space in existing animal housing and support facilities at the MD Anderson North Campus Vivarium (NCV) to provide additional rodent housing, procedure, and support space to meet current and future needs. The Project site is located at the MD Anderson 1515 Holcombe Campus, which is situated north of Holcombe Boulevard and east of Bertner Avenue in the Texas Medical Center. Refer to Attachment A for the project location map. B. The NCV is located in the Mitchell Basic Science Research Building (BSRB) and the Clinical Research Building (CRB). The BSRB facility includes rodent housing and support, centralized cage wash, and administrative office space. The centralized large animal housing, surgical support and imaging facilities, pathology laboratories, and support areas are located in the Issued: June 22, 2012 4 OF 24

Clinical Research Building (CRB) basement, which is adjacent to and physically connected to the BSRB. The CRB was occupied in 1999 and originally designed and used almost exclusively for large animal housing and support. C. To address space limitations of the NCV, which include limited rodent housing, procedure space, rodent quarantine space, and flexible procedural space, this Project is expected to accomplish the following objectives: 1. Objective 1: Renovate and expand the NCV housing, procedure, and support facilities to increase capacity by approximately 8500 cages of mice and add critically needed specialized rodent procedure space. The renovation will result in: a. Expanded rodent housing and support space. b. Quarantine space for conventional health status rodents. c. Procedure space for specialized research needs. d. Rightsizing of large animal housing and support space. 2. Objective 2: Augment the NCV infrastructure to include the addition of a new materials management corridor and extension of the Edstrom Watchdog and Viewport systems into the newly renovated space. Issued: June 22, 2012 5 OF 24

1.03 PROJECT DESCRIPTION A. This Project will renovate existing large animal housing space to expand the rodent housing and procedure space and will include a rodent quarantine facility as well as dedicated procedure rooms to support studies that require specialized equipment. B. The renovated space will be constructed in the basement of the CRB and the basement and first floor of the BSRB, encompassing approximately 17,000 gross square feet. Since the adjacent spaces must remain in operation and will be sensitive to noise and vibration during construction, the AE shall address potential phasing and operational strategies for implementing this Project. C. The renovation will utilize the principles of sustainable design through creation of a more efficient use of space, optimization of energy performance, and enhancement of indoor environmental quality. The Project includes an upgrade and expansion of environmental monitoring and task management systems into the CRB. D. The NCV is currently configured within close proximity to the receiving dock where animals can be received and held. E. All rodent holding rooms within the NCV shall be configured to allow conversion to procedure rooms if necessary. F. The renovated NCV will accommodate multi-species large animals and rodents in segregated space. The rodents will be contained in ventilated cage enclosures. G. Objective 1 Project Scope: Issued: June 22, 2012 6 OF 24

1. A primary component of the Project is the renovation, expansion, and equipping of rodent procedure and housing areas in the NCV facility. 2. This Project will expand the existing rodent housing and specialized procedure space. Procedure rooms, storage, housekeeping, and locker room expansion are included to support the additional rodent housing. 3. This Project will optimize the large animal housing, procedure, and surgical support space by reorganizing the area to create a more efficient facility to meet current and future program needs. These facilities will be reconfigured to allow for logical adjacencies between rodent and large animal housing and required procedure space. 4. Additional housing and husbandry support equipment to be purchased includes Tecniplast ventilated cages and racks, mobile large animal cages, Tecniplast animal transport racks, and essential equipment such as biological safety cabinets. H. Objective 2 Project Scope: 1. Materials Management Corridor: a. The current connection between CRB and BSRB was not designed for equipment traffic between these two buildings and is inappropriate because it routes through office and barrier entrance areas. Construction of a new connection corridor between CRB and BSRB will allow movement of rodent caging and equipment directly between the CRB and the BSRB equipment elevator. Issued: June 22, 2012 7 OF 24

1.04 PROGRAM b. This corridor reconfiguration will facilitate daily operations by shortening the route between housing and processing areas and allow rerouting of contaminated equipment away from clean hallways and personnel areas. 2. Edstrom Watchdog and Viewport Expansion to CRB: a. The NCV rodent housing areas in BSRB are equipped with state-of-the-art electronic environmental monitoring and task management systems. This Project will expand the existing Edstrom Watchdog and Viewport Systems into the CRB rodent and large animal housing space to enhance environmental monitoring and add electronic room-level access control, a level of security already provided in the BSRB rodent housing areas. b. Electronic access control will provide enhanced protection for high profile species housed in the CRB, including dogs and nonhuman primates. 3. Office Space Relocation: a. Administrative office space within the CRB facility will be relocated outside the Project site so that this space can be used for animal support. b. The office relocation scope will be accomplished under this Project. A. The AE will be required to develop a Facility Program in the form of a Pre-Design Report for MD Anderson departmental approval. MD Anderson will furnish conceptual program information to the selected AE. Issued: June 22, 2012 8 OF 24

B. The Project program must accommodate the following functions: 1. Large size rodent housing rooms designed for high density housing using individually ventilated cages in a library-style configuration. 2. Small size rodent housing rooms to support special needs such as reverse light cycle or unusual environmental parameters. 3. Multi-user rodent invasive procedure rooms with multi-station rodent anesthesia machines, waste anesthetic gas scavenging equipment, multi-user surgical stations, and specialized surgical lighting and microscopes. 4. Storage rooms. 5. Housekeeping room. 6. Locker room expansion for increased staff. 7. Quarantine space for rodents of undefined or non-barrier appropriate health status to support animal import activities and disease outbreak management. 8. Procedure space and support for specialized research needs. 9. Materials management corridor. 10. Small combination housing / procedure suites for behavioral or physiological testing of rodents. 11. Sperm Cryopreservation system. Issued: June 22, 2012 9 OF 24

12. Large animal housing rooms to receive minimal renovation for mobile cages and infrastructure upgrades. 13. Clinic and operating room prep rooms; relocated to accommodate increased rodent housing space. 14. Microsurgery room relocation and expansion. 15. Conference / training room for multi-purpose function. CONSTRUCTION SYSTEMS AND ASSEMBLIES 1.05 GENERAL A. This section identifies applicable Owner s Design Guideline Elements A through G and Element Z that the AE must use for this Project s design. B. In addition, existing facility information and construction components and infrastructure systems that are unique to this Project are described below. 1.06 ELEMENT A SUBSTRUCTURE A. Not applicable to this Project. 1.07 ELEMENT B SHELL A. Not applicable to this Project. Issued: June 22, 2012 10 OF 24

1.08 ELEMENT C INTERIORS A. During the Project s Design Phase, MD Anderson will furnish the AE interior finishes standards appropriate for the Project. B. Existing interior partitions are concrete masonry with block filler. C. New interior partitions shall be constructed of metal stud construction with impact and moisture resistant gypsum board. D. Finish for vivarium walls shall be water based epoxy paint. E. New walls in rodent holding rooms shall be metal stud construction designed to meet noise and impact resistance criteria set out in ASHRAE and ANSI. Provide staggered studs with sound attenuation blankets and impact and moisture resistant gypsum board coated with waterproof epoxy paint. F. Finish for toilet rooms shall be ceramic tile. G. Vivarium floors shall be fluid applied epoxy resin. H. Vivarium ceilings shall be impact resistant gypsum board with a minimum height of 8-6. I. Corridor widths are generally 7-0 with a minimum width of 6-0. J. Refer to Owner s Design Guideline Element C for additional requirements. Issued: June 22, 2012 11 OF 24

1.09 ELEMENT D SERVICES A. Plumbing: 1. Modify the existing plumbing systems to accommodate the revised room configurations. 2. The domestic water system consists of four (4) variable speed pumps with a redundant pump and associated storage tank. 3. The domestic water heating system consists of three (3) steam to hot water heaters and associated re-circulating pumps. 4. Update existing reverse osmosis (RO) water and animal watering systems to serve the new holding rooms. 5. Carbon dioxide is available for procedure room equipment. 6. Refer to Owner s Design Guideline Element D20 for additional requirements. B. Heating, Ventilating, and Air Conditioning: 1. General a. The AE must thoroughly evaluate the existing systems to ensure that the design intent of the project can be accommodated. b. The AE shall explore the opportunity to reduce energy consumption in the vivarium by lowering the existing minimum air change rates (ACR),). The existing HVAC control system will need to be upgraded. The existing constant volume supply and Issued: June 22, 2012 12 OF 24

exhaust terminal units for each zone must be replaced with low pressure drop tracking valves capable of providing at least four different air change rates (4, 6, 10, and 15 air changes per hour). c. The individual room ACR shall be easily adjustable remotely via the building automation system. The ACR is based on the room s usage and the animals housed. The room air change rates in the existing large animal holding rooms has recently been reset to 15 air changes per hour (ACH). Flexibility shall be provided to reduce the air change rates further because of the proposed rodent ventilated cage racks. 2. Chilled Water System: a. The Thermal Energy Corporation (TECO) provides chilled water and steam to the 1515 Holcombe Campus via underground distribution piping. Primary chilled water, steam production and distribution equipment redundancies to maintain 24/7 operations are accommodated by TECO. Redundant plate and frame heat exchangers and variable speed pumps provide secondary chilled water to the vivarium air-handling units. 3. Steam and Heating Hot Water System: a. Heating hot water for the air handling unit preheat coils and the terminal unit reheat coils is provided by three (3) steam-to-hot water converters and three (3) variable speed pumps, with one pump and one converter being redundant. b. 70# house steam serves the cage wash equipment. Issued: June 22, 2012 13 OF 24

c. 70# house steam serves the clean steam generator that provides steam to the humidifier in the vivarium air handler. 4. Air Handling Systems: a. The CRB basement is currently served from two (2) 100% outside air Fan Wall air handling units outfitted with 95% final filters. One unit is dedicated to holding rooms and vivarium space while the other unit serves laboratory areas and support space. The air handler serving the holding rooms is equipped with a clean steam humidifier to maintain 50% relative humidity in the animal holding rooms. b. Constant volume pressure independent terminal units with hot water reheat coils serve each zone/holding room. c. The existing HVAC system for various animal species can accommodate zone temperature ranges from 66 to 78 degrees Fahrenheit. 5. Exhaust and Ventilation Systems: a. Several redundant, dedicated exhaust systems serve the CRB basement including general animal exhaust, fume hood exhaust, biological safety cabinet and radioisotope exhaust. b. Pressure independent exhaust air terminal units control zone exhaust. 6. Refer to Owner s Design Guideline Element D30 for additional requirements. C. Fire Protection: Issued: June 22, 2012 14 OF 24

1. Modify existing fire protection systems to accommodate the revised room configurations. 2. The fire protection sprinkler system is fully automatic, and includes a fire pump, jockey pump, storage tank and fire department connections. 3. Refer to Owner s Design Guideline Element D40 for additional requirements. D. Electrical: 1. Service and Distribution: a. Utility power from CenterPoint Energy (CPE) with CPE switches and transformers located outside the facility serve the basement Clinical Research Building vivarium. b. The 4.16kV normal power main switchgear delivers normal utility power to the double-ended 277/480V substations. The double-ended 277/480V substations supply normal power to the building 277/480V loads via distribution panels and panelboards, to emergency power automatic transfer switches, and to 480/208V transformers. 2. Lighting: a. Adjust existing lighting levels to current industry requirements and configure lighting control to meet the rodent nocturnal cycles. Holding room lighting must be controlled through the expanded Edstrom Watchdog system. b. Specify red tube lighting to minimize disrupting the rodents during the night cycle. Issued: June 22, 2012 15 OF 24

3. Emergency Power: a. On-site main essential switchboards and 1500kW, 480/277V emergency generators supply emergency power to the facility. b. The 480V essential system switchboards supply emergency power to the facility emergency loads via automatic transfer switches. c. All HVAC control systems and equipment are on emergency power. 4. Fire Alarm System: a. Addressable automatic fire detection and alarm system with emergency voice/alarm communications and fire department communication system is installed in the facility. b. The application, installation, location, performance, inspection, testing, and maintenance of fire alarm systems, supervising station alarm systems, public emergency alarm reporting systems, fire warning equipment and emergency communications systems (ECS), and their components shall comply with NFPA 72. 5. Refer to Owner s Design Guideline Element D50 for additional requirements. 6. Refer to MD Anderson ARSAC Design Standards for Small Animals (Rodents) Vivarium for electrical requirements in vivarium space. 7. Special requirements for conduit systems installed in vivarium space. Issued: June 22, 2012 16 OF 24

a. Provide an air-tight electrical conduit installation in vivarium space, which allows decontamination of the vivarium space and prevents vermin harborage in and transmission through the electrical distribution systems. Thread fittings shall be utilized for conduit installation. Conduits, junction boxes and outlet boxes that have openings into vivarium space shall be sealed and gasketed at both ends wherever is applicable, one in vivarium space and the other in non-vivarium space. b. This requirement also applies to lighting fixtures, timers, switches, electrical outlet and other devices that are located in vivarium space. c. Obtaining Owner s approval for proposed design and mockup is essential prior to installation. E. Telecommunications: 1. Confirm capacity and space for telecommunications equipment and security panel(s) to support the Project. 2. Refer to Element D5030 for additional telecommunications requirements. F. Security: 1. Security should enable locking of department suites with no adverse impact to means of egress requirements. 2. Evaluate means of egress impact to existing floors because of new occupancy means of egress configuration. Issued: June 22, 2012 17 OF 24

3. Security systems will include the following: Alarm monitoring, access control, video surveillance and recording, security communications, two-way radio coverage, and interface with fire/life safety systems. 4. Refer to Element D5038 for additional security requirements. 1.10 ELEMENT E EQUIPMENT AND FURNISHINGS A. No additional requirements; refer to Owner s Design Guideline Element E. 1.11 ELEMENT F SPECIAL CONSTRUCTION A. Not applicable to this Project. 1.12 ELEMENT G BUILDING SITEWORK A. Not applicable to this Project. 1.13 ELEMENT Z GENERAL DESIGN REQUIREMENTS A. Refer to Owner s Design Guideline Element Z for requirements. Issued: June 22, 2012 18 OF 24

SPECIAL ISSUES AND CONSIDERATIONS 1.14 TECHNICAL EVALUATIONS A. In addition to technical evaluations that are described within the Design Guideline Elements, Elements A through G and Element Z, the AE shall perform the following written technical evaluations with recommendations in a Ben Franklin format for MD Anderson review and approval. The Ben Franklin shall identify reasons for and against (pros and cons) a particular design alternative or issue to aid in the decision-making process. B. The following technical evaluations must be prepared during the Schematic Design phase: 1. Codes and standards analysis, including compliance with ANSI/ASHRAE/IESNA Standard 90.1-2010. 2. Evaluation of existing infrastructure systems, including HVAC, electrical, plumbing, fire protection, security, and telecommunications systems, to support the new program requirements. 1.15 WORK SESSIONS A. Proactively coordinate and schedule work sessions per Design Guideline Element Z2010 Part 2. In addition to issues identified by the AE, Contractor, and Owner during the Design Phase, the following are examples of topics to be evaluated through scheduled work sessions: 1. Laboratory equipment planning. Issued: June 22, 2012 19 OF 24

2. Infrastructure systems planning. 3. Interim life safety; coordination of life safety with security access control measures. 4. Interior finishes, furnishings, and equipment. 5. Sequences of operation for HVAC, plumbing, and electrical systems. PRODUCTS 1.16 GENERAL A. This section is intended to clarify certain specification requirements and to identify deviations from the MD Anderson Master Construction Specifications to assist the AE with specification editing. Refer to Owner's Design Guideline Element 2010 "Instructions for the Preparation of Project Manuals" for additional information. B. This Project takes exception to technical specification requirements identified within Table 2, page 6 of Design Guideline Element 2010, Instructions for the Preparation of Project Manuals. The AE shall create their own technical specification sections for Divisions 02-19 as applicable to the Project. Additional exceptions are noted below in this Products Section. C. Specification sections developed by the AE must follow the same formatting conventions as the Owner's Master Construction Specifications. Applicable sections of the Owner's Master Construction Specifications Divisions 20 through 28 must be used as template documents to be edited specifically for this Project. Issued: June 22, 2012 20 OF 24

1.17 DIVISION 00 AND 01 A. This Project falls under the Owner Controlled Insurance Program (OCIP). 1.18 DIVISION 08 A. The AE shall specify door hardware and full interface between specified door hardware, life safety / fire alarm, security (electronic and mechanical), and Texas Department of Licensing and Regulation (TDLR) connections for proper operation under normal and emergency operation. 1.19 DIVISION 10 A. Edit MD Anderson Master Construction Specification Section 10 44 00, Fire Extinguisher Cabinets and Accessories for the Project. 1.20 DIVISION 11 A. Edit MD Anderson Master Construction Specification Section 11 53 00, Laboratory Equipment for the Project. B. Owner is in the process of updating Specification Section 11 53 13, Chemical Fume Hoods and Biological Safety Cabinets, which will be available during the Design Phase. 1.21 DIVISION 20 A. No exceptions taken. Issued: June 22, 2012 21 OF 24

1.22 DIVISION 21 A. No exceptions taken. 1.23 DIVISION 22 A. No exceptions taken. 1.24 DIVISION 23 A. The AE must indicate the types of duct material changes that occur on the exhaust air systems flow diagrams and duct drawings. 1.25 DIVISION 25 A. Owner has two (2) different versions of DDC building automation specifications. For this project, edit the BAS Retrofit master construction specifications, which describe product and installation requirements for a Siemens Apogee system. B. In addition, edit MD Anderson Specialty Equipment Control Standard Drawing Templates for this Project. Create control drawings as necessary using the same format provided in the templates. For additional information visit the following Internet URL: http://www2.mdanderson.org/depts/cpm/standards/bas.html C. Owner prefers that the AE issue all sequences of operation for all control systems and provide all direction necessary to have the BAS directly control these systems. This preference requires the AE to provide all sequences of operation in the Construction Documents. Owner wishes to eliminate third party manufacturer supplied controllers with Issued: June 22, 2012 22 OF 24

1.26 DIVISION 26 packaged units and/or gateway/interface (aka black box ) to the BAS units whenever possible. For example, domestic water packaged unit utilizing PLC (Programmable Logic Controller). A. The primary consideration for specifying lighting fixtures shall be per the MD Anderson standard lighting fixture schedule; reference Design Guideline Element D5022, Master Lighting Fixture Schedule. 1. The AE may present, however, alternate lighting fixture types and styles for Owner s review and consideration. AE should provide alternate lighting fixture manufacturers and model numbers on lighting fixture schedules within the Construction Documents for bidding. 2. Emphasis for final selection remains on institutional standardization of internal lighting fixture components and spare parts. 3. Special consideration should be given for lighting fixtures within vivarium spaces. B. Specify LED lamps for all warning signs; no incandescent lamps shall be used. C. For all specified equipment that requires 3-phase electrical power and for equipment not controlled by a variable frequency drive, specify loss-of-phase protection in the applicable equipment specifications and single line electrical drawings. Issued: June 22, 2012 23 OF 24

1.27 DIVISION 27 A. Cable trays pathways must be identified early in the Design Phase. B. Specify Siemens cabling for any new telecommunications cabling. 1.28 DIVISION 28 A. Owner is in the process of updating Specification Section 28 05 00 Electronic Safety and Security, which will be available during the Design Phase. END OF ELEMENT 1010 Issued: June 22, 2012 24 OF 24