User Manual. TN1500 Embedding Center. Read Prior to Operation! Always keep this manual near the unit! WP

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User Manual TN1500 Embedding Center Read Prior to Operation! Always keep this manual near the unit! WP46818 06.02.15

User Manual TN1500-Embedding Center 888.708.5233 Info@TannerScientific.com www.tannerscientific.com Contents 1 General Summary...Page 2 2 Installation...3 3 Technical Parameters...4 4 Safety Precautions...5 5 Equipment Overview...6 6 Operation...10 6.1 Main Control Panel Setup...Page 11 6.2 Temperature Setting...11 6.3 Timer Setting...12 6.4 Clock Setting...13 6.5 Running Manual Mode...13 6.6 Cooling Plate Operation...14 7 Cleaning & Maintenance...15 8 Warranty & Service...15 9 Troubleshooting...16 Tanner Scientific TN1500 - Embedding Center 1

1 General Summary This instrument was a collaborative effort developed using input from over 100 Histologists in the United States. Tanner Scientific TN-1500 Tissue Embedding Center and Cooling Plate are intended to embed and cool pathological tissue. Features: Pre-set On/Off timer for every day of the week. Histo-trimmers on both ends of the hot plate are convenient for both left and right hand users. Adjustable magnifier for easy viewing. Two modes of operation: automatic and manual. Temperature control functions located on 5 parts. Multiple over-heat protection devices. Keys with light indicator. Low voltage and adjustable LED illumination system w/adjustable flow tube. Two module configurable options (left to right or right to left). Tanner Scientific TN1500-Embedding Center 2 Tanner Scientific TN1500 - Embedding Center

2 Installation Transportation Only transport the instrument vertically! Any other position can cause damage. Unpacking Examine the package before opening. If damaged, do NOT open and immediately contact Tanner Scientific, and the transportation carrier. Unpack the carton removing all components and user manual. Remove the unit from the carton using the two black securing straps. When lifting the instrument, be sure to hold both sides by its base plate. Placement Place the instrument on an even and steady surface to avert vibration. Do NOT operate the instrument under a fan or directly below an A/C duct. Do NOT operate the instrument around any electromagnetic interference. Do NOT place the instrument near any explosive or flammable materials. Do NOT place the instrument in an area where it would be exposed to direct sunlight. The back of the instrument MUST be placed at least 15cm away from the wall. If the instrument is placed closer than 15cm from the wall, it can cause substantial damage to the instrument and can invalidate the warranty. Power Supply An independent grounding power socket should be used for the machine. Only use the power supply line supplied with the instrument to connect with the socket. Make sure the grounding line of the 3-line power is securely connected before starting the machine in compliance with the GB9706.1 standards. Tanner Scientific TN1500 - Embedding Center 3

3 Technical Parameters Power Supply: 110V, 60Hz Fuses: 15 AMP x 2 Power Consumption: 1000VA Operating Temperature Range: 15 Cooling System: DC 12/24 V Compressor Refrigerant: R134A Dimensions (LxDxH): 26.5 x 22.75 x 16.5 Weight: 77lbs Paraffin Reservoir: 6L Thermal Chambers: Approx. 1.5L Cold Plate: Approx. 80 Cassettes Working Environment Operate in an ambient temperature range of 5-40 C. Humidity should be less than 80%. Atmospheric Pressure: 860 hpa 1060 hpa. All heated components include overheat protection. Temperature Control Functional Unit Temperature Range Heated Separately Separate Temperature Control Warm-Up Time Prior to Operation Paraffin Reservoir 0 C to 85 C + + 2 hrs Paraffin Dispenser 0 C to 85 C + + 15-20 min Thermal Chambers 0 C to 85 C + + 15-20 min Hot Plate 0 C to 85 C + + 15-20 min Cold Plate 0 C to -10 C + + 30 min Forceps Holders 0 C to 85 C 15-20 min 4 Tanner Scientific TN1500 - Embedding Center

4 Safety Precautions This instrument should only be operated by qualified personnel. Read the user manual in full before use of this instrument. Turn off and disconnect the instrument from its power supply before changing or cleaning any of its parts. Be aware there is a risk of burning when operating. The paraffin reservoir, mold warmer, cassette bath, work area and forceps holders are all hot. Make sure the power supply complies with the specified requirements before use. Only connect to a grounded socket. The unit must not be exposed to direct sunlight or set up near an air condition vent. The back of the instrument must be placed at least 15cm from the wall. Attention: Use heating elements only as needed. Turn to sleep mode or away when not in use. Tanner Scientific TN1500 - Embedding Center 5

5 Equipment Overview Tanner Scientific TN1500-Embedding Center Image 5.1 1 2 12 4 3 11 9 6 5 8 7 1 Paraffin Tank 2 Main Control Panel 3 LED Light Control 4 Thermal Chamber 5 Paraffin Dispenser 6 Small Cryo Plate 7 Paraffin Waste Trays 8 Hot Plate 9 Forceps Holder 10 Rear Panels (On Back of Instrument) 11 Cooling Plate 12 Cooling Plate Control Panel 6 Tanner Scientific TN1500 - Embedding Center

Image 5.2 A Left Arrow A B B Right Arrow C Auto/Manual LCD Display Screen D Small Cryo Plate On/Off E Minus Key F Plus Key G Set Key G F E D C 1 Paraffin Tank Holds up to 6 liters of paraffin. Temperature can be adjusted in a range from 0 to 85 C. The reservoir has overheat protection in the event of a temperature control failure. 2 Main Control Panel To light up screen, press any key (except CRYO). The screen will enter into protection and power save mode after 15 minutes of no contact. 3 LED Light Control Press key, the LED light will become brighter. Press key, the LED light will become darker. 4 Thermal Chambers Used to keep the blocks warm. Has programmable temperature control. Removable transfer trays. 5 Paraffin Dispenser Has programmable temperature control. Flow control is adjustable. 6 Small Cryo Plate Located directly in front of the embedding area to ensure consistent, low temperatures during the filling of the molds. Set temperature allows cryo plate to cool to maximum ability. 7 Paraffin Waste Trays Two removable trays are located under the heated work areas to collect the excess paraffin drained from the surface. Empty and clean both trays daily. 8 Hot Plate Features a paraffin trimmer on both the left and right side. Has programmable temperature control. 9 Forceps Holder Maintains independent temperature. Tanner Scientific TN1500 - Embedding Center 7

10 Rear Panels Rear Panel of Embedding Center Image 5.3 A B C D A Main Power Switch & Socket B Foot Switch & Socket C Grounding Wire Connector D Socket for Cooling Plate Image 5.4 Rear Panel of Cooling Plate A B C D A Power Switch B Fuse Pocket C Power Socket E D Grounding Wire Connector E Back Cover * Panel components may change depending on date of manufacture. 8 Tanner Scientific TN1500 - Embedding Center

Cooling Plate & Cooling Plate Control Panel Image 5.5 Cooling Plate Power switch is located on the rear of the instrument. (Reference Image 5.4). Has programmable temperature control. Prior to operation, the cooling plate should be dry and free of paraffin to prevent frost buildup. Image 5.6 Cooling Plate Control Panel A B LCD Display Screen A Setting Indicator B Running Indicator C Set Key D Increase E Decrease C D E Tanner Scientific TN1500 - Embedding Center 9

6 Operation Please ensure that all preparatory steps have been completed and safety precautions have been reviewed prior to use. Getting Started Plugging In Before you connect the instrument to the main electrical source, please check that the power switch is in the (O) OFF position. Only use the power supply line provided with the instrument. Electrical socket must be a grounded socket. Connect power plug into the instrument before plugging into the electrical socket. Starting Up the Machine Turn on the main switch of the instrument. Reference Image 5.3 on page 8 for power switch location. LCD display screen on the main control panel will show the following picture: HOME SCREEN Paraffin Tank [AUTO MODE] Running...FRI 18:40 PARAFFIN: 65 C RIGHT: 65 C Right Thermal Chamber Working Table HOT PLATE: 55 C DISPENSER: 67 C LEFT: 55 C CRYO: Left Thermal Chamber Paraffin Dispenser Small Cryo-Plate 10 Tanner Scientific TN1500 - Embedding Center

6.1 Main Control Panel Setup Mode 1) Reference Image 5.2 on page 7 for the main control panel. 2) Place instrument into manual mode by pressing the AUTO/MAN key. Light will illuminate under MAN. 3) Press SET key to enter into set up mode. 4) The main control screen will show the following picture: SETUP SCREEN [SETUP MODE] SELECT (1 3) 1) TEMPERATURE 2) TIMER 3) CLOCK All settings, temperature and time parameters will be automatically recorded on the computer chip. When restarting the embedding center and pressing the AUTO/MAN key, it will run according to the pre-set parameters. 6.2 Temperature Setting 1) Select 1) TEMPERATURE using the keys. 2) Press SET key to enter into temperature setting status. 3) Choose the working zone. 4) Use (+) or ( ) to increase or decrease the temperature figures. 5) Once you have selected your desired temperature ranges, press the AUTO/MAN key to return back to the home screen. Tanner Scientific TN1500 - Embedding Center 11

Suggested Pre-Setting Temperatures for these 6 Working Zones: 1) Paraffin Tank: 65 C 3) Hot Plate: 55 C 5) Paraffin Dispenser: 67 C 2) Right Thermal Chamber: 65 C 4) Left Thermal Chamber: 55 C 6) Small Cryo Plate: NOTE: Paraffin dispenser should always be 2-3 C higher than paraffin tank. means section is heating. means heating has stopped. NOTE: When the instrument reaches the desired set temperature, the heating symbol will change from to. If the actual temperature is lower than the setting temperature, the symbol will automatically change as temperature adjusts. The unit is working only when these symbols are present and lit. 6.3 Timer Setting 1) Select 2) TIMER using the keys. 2) Press SET key to enter into time setting mode. 3) Use to select time and day. Press to choose time setting for Thursday-Sunday or to choose time setting for Monday-Wednesday. 4) Press (+) or ( ) to increase or decrease the time figure. 5) Press AUTO/MAN key to return back to the home screen. Example: To turn on at 7:30 and turn off at 16:30 on Tuesday, follow these steps: 1) Turn on the power and press AUTO/MAN key. 2) Press SET key; choose 2) TIMER. 3) Press to choose Tuesday and press (+) or ( ) to set 7:30 [ON] 16:30 [OFF]. NOTE: If on and off times are both 00:00, that means the instrument will not turn on that day. NOTE: If the instrument is turned on according to a pre-set starting time, it will automatically start to work at that time in automatic mode. 12 Tanner Scientific TN1500 - Embedding Center

6.4 Clock Setting 1) Select 3) CLOCK using the keys. 2) Press SET key to enter into current time setting mode. 3) Use to choose minute, hour, or week. 4) Use (+) or ( ) to increase or decrease time figures. 5) Press the AUTO/MAN key to return back to the home screen. [SET CLOCK] SELECT (1 3) 1) MINUTE: 05 2) HOUR: 09 3) WEEK: FRI 6.5 Running Manual Mode 1) To manually run the instrument, press AUTO/MAN key on the main control panel to enter into the manual interface. 2) Press to enter into running mode. Heating icons will appear, meaning all areas are warming up. 3) Press to return back to waiting mode. [AUTO MODE] Running...FRI 18:40 PARAFFIN: 65 C HOT PLATE: 55 C DISPENSER: 67 C RIGHT: 65 C LEFT: 55 C CRYO: [MAN MODE] Off Work FRI 18:40 PARAFFIN: 65 C HOT PLATE: 55 C DISPENSER: 67 C RIGHT: 65 C LEFT: 55 C CRYO: Tanner Scientific TN1500 - Embedding Center 13

6.6 Cooling Plate Operation 1) Reference Image 5.6 on page 9. 2) Connect the cooling plate to power source. Turn on the power switch located on the rear of the machine. Green light will illuminate. 3) Press SET key; the compressor will stop running. 4) Press (+) or ( ) to adjust the temperature. 5) Press the SET key to enter running mode. * Turn on 20 minutes prior to use to allow for temperature to be achieved. There are two indicator lights beside the screen. If the indicator light underneath is on, this means the compressor is working. If the indicator light on top is on, this means the compressor has stopped working. If the actual temperature is lower than setting temperature, the compressor will automatically stop running. When the actual temperature is higher than setting temperature, the compressor will restart. For convenience, the preset temperature range is -5 to -10 C. 14 Tanner Scientific TN1500 - Embedding Center

7 Cleaning & Maintenance Cleaning Equipment should be cleaned daily. Before performing all maintenance or cleaning of the equipment, turn off the power switch and unplug the instrument! Only household grade cleaners should be used for cleaning the instrument. Acetone and benzene will damage paint on the surface of the instrument. Wipe area using a soft cloth dampened in alcohol (70-75% isopropyl or ethyl solution) Do NOT wipe dry. Allow area to air dry to maximize disinfection. Changing the Fuse Only replace with the same model. (Refer to the Technical Parameters). Failure to comply could invalidate the warranty. 8 Warranty & Service Tanner Scientific warrantees this product for a period of one year from the date of purchase, provided that the customer complies with the rules of this manual. Extended warranties are available. Contact Tanner Scientific at 888.708.5233 for more information. Tanner Scientific will not be responsible for the damage and other problems caused by abuse and misuse of the instrument. Service Information If you require any service or parts during the warranty period, please contact Tanner Scientific at 888.708.5233 or the sales agent who sold you the unit. Prior to calling, please have the instrument model and serial number ready. Amendment Tanner Scientific reserves the right to change the technical parameters of any model for improving the function of our instruments. Quality Guarantee Tanner Scientific will ensure that every instrument sold has been strictly examined to ensure it meets our stringent quality and technical standards. Service terms are only provided for those who regularly use the instrument and operate the instrument according to its instructions. Disposal of Unwanted Instruments Discarding the instrument and its parts should be done according to current laws and regulations. Tanner Scientific TN1500 - Embedding Center 15

9 Troubleshooting EMBEDDING CENTER PROBLEMS CAUSES ELIMINATION + No response when powered on. + Power line not connected. + Switch isn t turned on. + Fuse isn t connected well or may be burned out. + Connect power line, turn on again. + Press the switch indicator light on. + Check if fuse is good or not, change with another. + Light is not on. + Possible burnt fuse. + Check fuse or have technician check. + No heating. + No flow of paraffin liquid. + Possible burnt fuse. + Heating element defective. + Sensor not detecting. + Wax block is not melted enough. + Magnetic valve is blocked or switch is stuck with paraffin. + Contact technical support. + Check fuse or have technician check. + Not enough time for melting, continue heating. + Check switch. + Use hair dryer to melt wax around switch if necessary. + Contact technical support. + No flow of paraffin liquid or leak. + Faulty magnetic valve. + Contact technical support. + Sound is good as magnetic valve starts up but no flow. + Paraffin low. + Other things in magnetic valve. + Clean the paraffin screen. + Not enough time for melting, continue heating. + Contact technical support. + Light is twinkling when turned on. + Unstable power. + Check the power. + Starts to heat up when turned on, but turns off under work mode. + SSR is broken. + Contact technical support. COOLING PLATE PROBLEMS CAUSES ELIMINATION + Will not cool down. + Will cool down but temperature cannot reach setting temperature. + Bad wire connection. + Controller or compressor may be broken. + Fan does not work or airflow is blocked. + Not enough refrigerating fluid. + Check the wires. + Contact technical support. + Contact technical support. 16 Tanner Scientific TN1500 - Embedding Center

Information The information, notes, and figures that appear in this user manual represent the present state of knowledge as we comprehend it. Tanner Scientific reserves the right to modify any specifications as well as manufacturing procedures without prior notice. This makes it possible to continuously improve the technology and manufacturing technique used in our products. For inaccurate statements, drawings, and technical illustrations in this user manual we exclude liability as far as permissible. No liability is accepted for any monetary loss or consequential damage caused by or related to compliance with statements or other information in this user manual. Tanner Scientific has no obligation to update the present manual periodically and on a continuing basis according to the latest technical developments, nor to provide customers with extra copies or updates of this user manual. This document is protected under copyright laws. Any reproduction of illustrations or text requires prompt documented consent by Tanner Scientific. Statements, drawings, illustrations and other information regarding contents or technical details of the present user manual are not to be considered as warranted characteristics of our products. These are determined only by the contract provisions agreed between us and our customers. Refer to the name plate on the back of the unit for the serial number and manufacturing date of this instrument. Tanner Scientific 1073 Tallevast Rd Sarasota, Florida 34243 888.708.5233 Info@TannerScientific.com www.tannerscientific.com

1073 Tallevast Rd Sarasota, Florida 34243 888.708.5233 Info@TannerScientific.com www.tannerscientific.com