Benchtop Pro with Omnitronics

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Benchtop Pro with Omnitronics The VirTis BenchTop Pro freeze dryers have been designed to meet the needs of the most demanding research laboratories. Each system can be configured to accommodate present and future requirements. Condenser refrigeration packages of -55 C, -75 C, -85 C and -105 C can meet the demands of both aqueous or aqueous-solvent based formulations. You can configure your system to run just a few samples or to process a relatively heavy load with condenser size choices of 3 liter, 8 liter or 9 liter. Selecting a size and temperature configuration allows you to maximize the use of the freeze dryer in your lab while not paying needlessly for unnecessary capacity or refrigeration. Each system can be configured to meet the needs of the most demanding research laboratories. 02

Manifolds Manifolds are available in a variety of styles and are designed to be interchangeable. There are a number of considerations when selecting a manifold. In a multi-user lab it is often best to utilize a robust stainless steel manifold. In applications where inorganic solvents are being utilized or you are rack drying and want to ensure visibility an acrylic manifold would be preferred. In applications with organic solvents the stainless steel manifolds will provide long lasting use. 03

Omnitronics Controller The Omnitronics Controller simplifies freeze drying and makes the system easy to operate. One touch start up and shut down ensure that your product and freeze dryer are protected from inappropriate procedures. The graphic display provides at-aglance understanding of the status of the freeze dryer and whether or not appropriate freeze drying conditions exist. Audible alarms help notify the user of potential problems with the system and hence, with the product. All Omnitronics controllers come complete with a trending screen that allows you to watch critical parameters on an on-going basis if required. Utilizing the optional Ethernet control, you can connect the freeze dryer to your company s or institution s network, and monitor and/or control your freeze dryer from any other location on the network. The Ethernet option also allows print out in a batch record, alphanumeric, type report. One touch start up and shut down ensure that your product and freeze dryer are protected from inappropriate procedures. 04

Don t waste time with slow & messy defrosting The hot gas defrost in the BenchTop Pro allows for fast turnaround time and helps minimize clean up efforts when having to pour warm water into a condenser. In addition, corrosive solvents which are more active at ambient and higher temperatures will spend a minimum amount of dwell time in the condenser with fast hot gas defrost no need to wait overnight to drain the system. 05

VirTis/SP Scientific supports your freeze drying endeavors with a team of technically qualified associates who can help you choose the right system and provide you with helpful application tips. In addition, SP Scientific provides the globally recognized LyoLearn Webinar series. These are free webinars, provided by industry experts on topics of interest to the freeze drying community. Our technical papers and application notes can be downloaded from our website at your convenience and are designed to help you get the most out of your freeze dryer. Standard Omnitronics High performance PLC controller Easy to use interface provided by full color touch screen navigation. Ensure a longer lifetime for your freeze dryer by avoiding utility degradation conditions such as high ambient and low voltage with alert notifications Real time graphical screen data logging to review system parameters during a run Help protect your product from unfavorable conditions with out of range and in range for freeze drying indicators Save time with one button start-up and one button shut-down Stores years of data on micro memory card Set point control with automatic PID tuning Precise alpha-numeric display of setting and read-out temperatures Currently available in English, Spanish, German & French. Other languages may be available on request. User selectable pressure in millibars, millitor or pascals. Temperature in C or F Omnitronics with Ethernet Option Control and/or monitor your system from anywhere on your network Enable the freeze dryer to email you if there is a process alert/alarm Full reporting capabilities with batch reports that can be exported to Windows Excel Optional remote service support by allowing our qualified technicians to access your system 06

Features of the BenchTop Pro Condensers of 3, 8 and 9 liters in a bench top footprint Refrigeration packages for maximum low temperature of -55, -75, -85 or -105 C One touch start-up and shut-down Pressure control to avoid back-streaming or for faster freeze drying A variety of manifolds to accommodate most processing configurations Rugged and reliable Pirani vacuum sensor Hot gas defrost in approximately 10 minutes or less Optional vacuum pump isolation valve Selection Guide There are two main criteria for selecting the benchtop freeze dryer that is right for you. The first is determining what condenser capacity you need in between defrost cycles. The second is to determine what solvents you may be using in your process. When utilizing water as the only solvent the highest condenser temperature offered is appropriate. In cases where organic or inorganic solvents are being utilized as part of the solvent matrix the lowest temperature condenser is always preferred. Load Capacity Solvents 3 Liter 8 Liter 9 Liter Water ES (-55 C) XL (-75 C) ES (-55 C) Water and inorganic solvents XL (-75 C) ZL (-105 C) EL (-85 C) Water & organic solvents XL (-75 C) ZL (-105 C) EL (-85 C) Manifold Material Choice Acrylic or stainless steel. Multiple user labs may have better experience with stainless steel. Maximize use of acrylic and minimize use of stainless steel. Maximize use of stainless steel and minimize use of acrylic if possible. Vacuum Pump Considerations Standard oil sealed, rotary vane direct drive pump. When working in low pressure conditions consider a dry scroll pump if oil backstreaming is a concern. Standard pump with corrosion resistant oil or combination standard pump with diaphragm pump. Standard pump with corrosion resistant oil or combination standard pump with diaphragm pump. Water & both organic and inorganic solvents XL (-75 C) ZL (-105 C) EL (-85 C) Maximize use of acrylic if higher in organic solvents. Maximize use of stainless steel if higher in organic solvents. Combination standard pump with diagphragm pump. 07

BenchTop Pro with Omnitronics 3L Freeze Dryer The BenchTop Pro with Omnitronics 3 Liter system is designed as a personal freeze dryer or for small laboratories processing less product at any one time. This unit is available with all of the manifold choices that can be used on the larger benchtop system giving it the same flexibility and performance. Condenser temperature option of -55 C (-52 C for 50Hz) or -75 C (-72 C for 50Hz) CFC free refrigerants Overall condenser capacity of 3 liters Approximate 24 hour rating of 2 liters/24 hour (extreme pressure and temperature, water only)* Omnitronics Control for monitoring critical freeze drying parameters and for vacuum control Remote control, batch reporting and emailed alarms with Ethernet interface Fast turnaround time with hot gas defrost and smooth condenser walls Alarms for out-of-range conditions *The 24 hour rating is not reproducible in the lab with product. This rating is to illustrate the efficiency of the refrigeration design from one system to another. It is based on loading as much water onto the freeze dryer in 24 hours as possible with equipment not typically used in freeze drying applications 08 BenchTop Pro with Omnitronics 3 Liter Freeze Dryer Condenser blank off (no load) temperature Condenser capacity in 24 hours (water, heaviest load) Overall condenser capacity Omnitronics control * Vacuum indication in millitor, microbar or pascals (user selectable) * Temperature indication in C or F (user selectable) * Voltage and ambient temperature indicators ES -55 C (-52 C for 50Hz) / XL -75 C (-72 C for 50Hz) Approximately 2 Liters 3 Liters Atmospheric to 1 mt "T" type thermocouples Alarms if out of acceptable range for system * Communication ports Ethernet connection Defrost Method Hot gas System refrigerant CFC free Condenser type Smooth wall interior with bottom external coil Compressor(s) ES is 1/3 HP, XL is 3/8 HP Average time for pull down to 100 mt 15 minutes Ultimate system vacuum with manifold 20 mt Base cabinet dimensions W x D x H 15.5in x 28.5in x 17in (39.4cm x 72.4cm x 43.2cm) Weight 60 lbs (27.3 kg) (unpackaged and without manifold) Standard Voltages 100-120V 50/60Hz, 200-240V 50Hz/208-230V 60Hz Manifold and Vacuum Pumps Sold Separately - See Accessories Current as of May 2013, Specifications are subject to change

BenchTop Pro with Omnitronics 8L Freeze Dryer The BenchTop Pro with Omnitronics 8 liter is designed for heavier loads and for use with solvents other than water. It is available with a -75 C or -105 C condenser. The -105 C option is preferred for applications involving low freezing point solvents such as TFA, acetronitrile and alcohols. Even if the freezing point of your solvent is below -105 C this temperature condenser is more likely to liquefy the solvent and thus prevent it from migrating easily to the vacuum pump. Offered in low and ultra-low condenser configuration -75 C (-72 C for 50Hz) or -105 C (-102 C for 50Hz) CFC free refrigerants Condenser capacity total of 8 liters Approximate 24 hour rating of 3 liters/24 hours (extreme pressure and temperature, water only)* Omnitronics Control for monitoring critical freeze drying parameters and for vacuum control Remote control, batch reporting and emailed alarms with Ethernet interface Fast turn around with hot gas defrost. Alarms for out-of range-conditions *The 24 hour rating is not reproducible in the lab with product. This rating is to illustrate the efficiency of the refrigeration design from one system to another. It is based on loading as much water onto the freeze dryer in 24 hours as possible with equipment not typically used in freeze drying applications BenchTop Pro with Omnitronics 8 Liter Freeze Dryer Condenser blank off (no load) temperature Condenser capacity in 24 hours (water, heaviest load) Overall condenser capacity Omnitronics control * Vacuum indication in millitor, microbar or pascals (user selectable) * Temperature indication in C or F (user selectable) * Voltage and ambient temperature indicators XL -75 C (-72 C for 50Hz) /ZL -105 C (-102 C for 50Hz) Approximately 3 Liters 8 Liters Atmospheric to 1 mt "T" type thermocouples Alarms if out of acceptable range for system * Communication ports Ethernet connection Defrost Method Hot gas System refrigerant CFC free Condenser type Smooth wall interior with bottom external coil Compressor(s) XL is 3/8 HP, ZL is 1/3 HP and 3/8 HP Average time for pull down to 100 mt 18 minutes Ultimate system vacuum with manifold 20 mt Base cabinet dimensions W x D x H 15.5in x 28.5in x 17in (39.4cm x 72.4cm x 43.2cm) Weight 131 lbs (59.4 kg) (unpackaged and without manifold) Standard Voltages 100-120V 50/60Hz, 200-240V 50Hz/208-230V 60Hz Manifold and Vacuum Pumps Sold Separately - See Accessories Current as of May 2013, Specifications are subject to change 09

BenchTop Pro with Omnitronics 9 Liter The BenchTop Pro with Omnitronics 9 liter is the high capacity workhorse of the bench top freeze dryer product family. Built for labs that require greater throughput and freeze drying availability, for some labs it will handle their weekly requirements without shut down and defrost. It is available with a -55 C or -85 C condenser Offered in low and ultra-low condenser configuration -55 C (-52 C for 50Hz) or -85 C (-85 C for 50Hz) CFC free refrigerants Condenser capacity total of 9 liters Approximate 24 hour rating of 5 liters/24 hours (extreme pressure and temperature, water only)* Omnitronics Control for monitoring critical freeze drying parameters and for vacuum control Remote control, batch reporting and emailed alarms with Ethernet interface Fast turn around with hot gas defrost. Alarms for out-of range-conditions *The 24 hour rating is not reproducible in the lab with product. This rating is to illustrate the efficiency of the refrigeration design from one system to another. It is based on loading as much water onto the freeze dryer in 24 hours as possible with equipment not typically used in freeze drying applications 10 BenchTop Pro with Omnitronics 9 Liter Freeze Dryer Condenser blank off (no load) temperature Condenser capacity in 24 hours (water, heaviest load) Overall condenser capacity Omnitronics control * Vacuum indication in millitor, microbar or pascals (user selectable) * Temperature indication in C or F (user selectable) * Voltage and ambient temperature indicators ES -55 C (-52 C for 50Hz) /EL -85 C (-82 C for 50Hz) Approximately 5 Liters 9 Liters Atmospheric to 1 mt "T" type thermocouples Alarms if out of acceptable range for system * Communication ports Ethernet connection Defrost Method Hot gas System refrigerant CFC free Condenser type Internal Coil Compressor(s) ES is 1/3 HP, EL is 1/3 HP and 3/8 HP Average time for pull down to 100 mt 18 minutes Ultimate system vacuum with manifold 20 mt Base cabinet dimensions W x D x H 15.5in x 28.5in x 17in (39.4cm x 72.4cm x 43.2cm) Weight (lb/kg) 131 lbs (59.4 kg) (unpackaged and without manifold) Standard Voltages 100-120V 50/60Hz, 200-240V 50Hz/208-230V 60Hz Manifold and Vacuum Pumps Sold Separately - See Accessories Current as of May 2013, Specifications are subject to change

Accessories for the BenchTop Pro Tree or T type Manifolds Available in 8 or 12 port configuration. 316 Stainless steel complete with Quick Seal Valves and built in adaptor plate. Part Number Description Dimensions BTP-MST-08 Stainless steel manifold, 8 ports BTP-MST-12 Stainless steel manifold, 12 ports HEIGHT 19.25 (48.9 CM), LENGTH 15 (38.1 CM), WIDTH 15.25 (38.74 CM) HEIGHT 19.25 (48.9 CM), LENGTH 15 (38.1 CM), WIDTH 23 (58.42 CM) Condensate Drip Pan Kit for Tree of T Type Manifolds This condensate drip pan kit will provide support for flasks on the Tree manifold and also collect condensate as it drips off the outside of the product containers during freeze drying. Part Number CPK Description Stainless steel flask support with plastic trays Condensate Drip Pan Kit for Tree of T Type Manifolds This condensate drip pan kit will provide support for flasks on the Tree manifold and also collect condensate as it drips off the outside of the product containers during freeze drying. Part Number CPK Description Stainless steel flask support with plastic trays Vertical Manifold Available in 12 port configuration. 316 stainless steel complete with Quick Seal Valves and built in adaptor plate. Part Number Description Dimensions BTP-MSV-12 Stainless steel manifold, 12 ports HEIGHT 16.25 (41.28 CM), LENGTH 15 (38.1 CM), WIDTH 15 (38.1 CM) Part Number CPK Description Stainless steel flask support with plastic trays 11

Drum Manifolds Classic drum type manifolds are available in both stainless steel and acrylic configuration. Comes complete with condenser adaptor plate of same material. Accessory racks can be coupled with these manifolds for rack drying either heated or unheated. Part Number Description Dimensions BTP-DA-08-0 8 port acrylic drum manifold DRUM - HEIGHT 12.25 (31.12 CM) ID 14.25 (36.2 CM) OD, WIDTH Ø9 (22.86 CM) ID, Ø9.5 (24.13 CM) OD ADAPTER PLATE HEIGHT 1 (2.54 CM), WIDTH Ø15 (38.1 CM) OVERALL ASSEMBLY HEIGHT 15 (38.1 CM), WIDTH Ø18 (45.72 CM) WITH QUICK SEAL VALVES INSTALLED BTP-DA-12-0 12 port acrylic drum manifold DRUM HEIGHT 16.25 (41.28 CM) ID, 18 (45.72 CM) OD, WIDTH Ø11.5 (29.21 CM) ID, Ø 12 (30.48 CM) OD ADAPTER PLATE HEIGHT 1 (2.54 CM), WIDTH Ø15 (38.1 CM), OVERALL ASSEMBLY HEIGHT 18.75, WIDTH Ø20.5 (52.07 CM) WITH QUICK SEAL VALVES INSTALLED BTP-DA-12-H BTP-DS-18-0 12 port acrylic drum manifold for use with heated racks 18 port stainless steel drum manifold DRUM - HEIGHT 16.25 (41.28 CM) ID, 18 (45.72 CM) OD, WIDTH Ø11.5 (29.21 CM) ID, Ø12 (30.48 CM) OD ADAPTER PLATE - HEIGHT 1.5 (3.81 CM), WIDTH Ø15 (38.1 CM) OVERALL ASSEMBLY HEIGHT 19.25, WIDTH Ø20.5 (52.07) WITH QUICK SEAL VALVES INSTALLED DRUM - HEIGHT 13 (33.02 CM) ID, 13.25 (33.66 CM) OD, WIDTH Ø12 (30.48 CM) ID, Ø13 (33.02 CM) OD SST ADAPTER PLATE HEIGHT 0.25 (0.64 CM), WIDTH Ø15 (38.1 CM) ACRYLIC COVER HEIGHT 0.75 (1.91 CM), WIDTH Ø13.5 (34.29) OVERALL ASSEMBLY HEIGHT 14.25 (36.2 CM), WIDTH Ø21 (Ø53.34 CM) WITH QUICK SEAL VALVES INSTALLED Drum Manifold Racks Racks are constructed of 304 stainless steel and adjustable. Part Number Description Dimensions BR-3U-08 3 tiered rack for BTP-DA-08 HEIGHT 10.5 (26.67 CM), WIDTH Ø8.5 (21.59 CM), SPACING 3.50 (8.89 CM) BR-3U-12 3 tiered rack for BTP-DA-12 HEIGHT 14.5 (36.83 CM), WIDTH Ø10.5 (26.67 CM), SPACING 4.75 (12.07 CM) BR-3U-18 3 tiered rack for BTP-DA-18 HEIGHT 12 (30.48 CM), WIDTH Ø10.5 (26.67 CM), SPACING 3.75 (9.53 CM) BR-3H-13 3 tiered rack for BTP-DA-12 with on off heater HEIGHT 12 (30.48 CM), WIDTH Ø8.5 (21.59 CM), SPACING 4.75 (12.07 CM) 12

Wide Mouth Filter Seal Flasks These borosilicate flasks are specially designed for manifold freeze drying. The flat bottom makes it easy to stabilize the flask in its upright position for plug or static freezing. The wide mouth of the flask makes it easier to place product in the flask and perhaps even more importantly, remove product from the flask. The snap on silicone top ensures a good vacuum seal and comes complete with a filter to eliminate the possibility of cross contamination when several flasks are on the same dryer. All components can be autoclaved. The flask itself is available in regular and in safety coated configurations. Must be used with manifold adaptors. Regular Flask Part Number Safety Coated Part Number Maximum Capacity Maximum Fill 235390 312892 40 ml 20 ml 235382 312900 75 ml 35 ml 118174 312918 150 ml 75 ml 118208 312918 300 ml 150 ml 118232 312934 600 ml 300 ml 118273 312942 1200 ml 600 ml 118307 312959 2000 ml 1000 ml Manifold Adaptors Part Number Material Shape Port Size Compatible Flasks 367424 Plastic Straight Barb ¾ 150 2000 ml 179655 Glass Straight ¾ 150 2000 ml 177923 Stainless steel Straight ¾ 150 2000 ml 177899 Glass 45 degree ¾ 150 2000 ml 177931 Stainless steel 45 degree ¾ 150 2000 ml 179622 Glass Straight ¾ 40 & 75 ml 177873 Glass 45 degree ¾ 40 & 75 ml Don t see the adaptor you need? Please inquire. 13

Ampule Adaptor Designed to hold 19 ampule type containers on a single valve Part Number Description 413534 19 port ampule adaptor We also carry a full line of sealing torches and ampules. Please inquire. Container System Two container systems are offered. One for bulk and one for stoppering applications. Containers are made of 304 SS and are attached to your manifold with vacuum tubing for processing in bulk or in vials. Part Number Description Dimensions 438032 Bulk ss container SC-1 Small stoppering container 7 5 ml vials, 5 10 ml vials, 4 30 ml vials, 1 100 ml vial Vacuum Pumps VirTis/SP Scientific is pleased to offer a full line of vacuum pumps to solve any application need. Included in our offering are the standard two stage, oil sealed rotary direct drive vacuum pumps as well as dry scroll type pumps and combination pumps that are joining of the standard pump with a diaphragm pump for service in highly corrosive environments. 14 Vacuum Foreline Traps These traps are designed to help prevent the migration of contaminants to the vacuum pump or to minimize vacuum pump oil back-streaming. They are placed in the vacuum line between the freeze dryer and the vacuum pump. Part Number FTA FTA-SS FTA-AC FTA-MS Description Filter trap housing, insert purchased separately Soda sorb insert for acid applications Activated charcoal insert for organic solvent applications Molecular sieve insert for water vapor and to help minimize oil backstreaming

SP Scientific Supports You in Ways Unrivaled in the Industry: LyoLearn Webinars: Free online seminar series featuring topics of interest to lyophilization scientists and presented by industry experts. Live sessions allow participants to interact with renowned freeze-drying specialists, such as Dr. John Carpenter, Dr. Steve Nail, Dr. Michael Pikal, and other who s who of the freeze drying community. Each online LyoLearn Session is recorded and archived for future viewing. Hands-On Training: SP Scientific s hands-on training courses offer attendees the chance to optimize their learning experiences by using tangible applications in a controlled setting. Led by go-to leaders in the lyophilization industry, these courses are a must for anyone getting started in freeze drying or scientists looking for collaborative environment to share best practices, ideas and theories. Technical Briefs: SP Scientific s technical briefs are relevant papers covering in-demand topics. Available in a variety of languages, titles include: The Relevance of Product Resistance in Primary Drying, The Importance of Controlling Nucleation Temperature During the Freeze Step, Case Studies in Diagnosing and Correcting Problematic Lyophilization Cycles and/or Formulations, Basic Principles of Freeze Drying, and Basic Lyophilizer Maintenance Helps to Assure Good Results. All of this is available on our website www.spscientific.com. Logon to learn more! 03

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