SEF Presents: Common Questions for a Chemical Safety Program Wednesday September 20, 2017
SEF Working Group Mission: Provide a Forum to share & promote best practices, and to disseminate timely information. Discussions will address various combinations of workplace safety, compliance, facility operations and management. Co-Chairs Title Company Dick Aichelmann Associate Director, EHS Denise Aronson President & Founder Betsy Parsons Associate Director, EHS Biogen Ironwood Pharmaceuticals Safety Partners Elias Witman Sustainability Coordinator Cell Signaling Technology Adam Wyner Senior Manager, EHS Vertex Pharmaceuticals
Upcoming SEF Forums 11/9/17 - JOINT EVENT WITH THE NFPA * NFPA 400, HAZARDOUS MATERIALS CODE * NFPA TOOLS & RESOURCES AT YOUR FINGERTIPS 12/3/17 - ELECTRICAL SAFETY
Today Common Questions for a Chemical Safety Program Speaker: Jonathan Eisenberg, Associate Principal, ARUP Intro: Denise Aronson, President & Founder, Safety Partners, Inc.
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Ventilated Enclosures Laminar Flow Cabinet Benchtop Hood Floor Mounted Hood Walk-In Hood Gas Cabinet 6
Hazardous Gases - Examples Hydrogen Ammonia Carbon monoxide 7
Ignition Control Container Types Effectiveness if Containers are Plastic??? 8 55 Gallon Plastic Drum 100% EtOH
9 Ignition Control Solvent Properties
Ignition Control - RH NFPA 77 Recommended Practice on Static Electricity Humidity Control to 65% minimum 10
Ignition Control Oxygen Reduction Inerting/Purging 11
12 Ignition Control Ventilation/Dilution
Ignition Control Flammable Liquid Flow Anti Static, PTFE Lined Hose Link to Bioflex brochure: http://bit.ly/2wtnixb 13
14 Ignition Control Flammable Liquid Flow
15 Electrical Hazards UL 1805/Fume Hoods
16 Flash Point vs. Fire Point NFPA 30
Flash Point & Fire Point Testing NFPA 30 Flash Point: Closed Cup, ASTM D56 Fire Point: Open Cup, ASTM D92 Both via certified testing lab 17
Flash Point vs. Fire Point Aqueous Solutions 18% EtOH - Flash Point = 140F - Fire Point = None 20% EtOH - Flash Point = 100F - Fire Point = None 18
Combustible Powders - Laws/Standards OSH Section 5 (a) (1) of the General Duty Clause NFPA 654 is enforceable - NFPA 484 (metals) - NFPA 664 (wood, paper, cellulosic materials) - NFPA 61 (agricultural/foods) - NFPA 120 (pulverized fuels) NFPA 652 NFPA 70 Article 500 (Class II locations) NFPA 499 extent of electrically classified locations NFPA 69 - Explosion Suppression & Isolation Systems 19
20 Combustible Powders Explosion Pentagon
Combustible Powders - NFPA 654 Evaluation of dust hazards (fire and explosion), including: - Review of previous fire event history - Housekeeping procedures - Electrical hazard classification - Hot work procedures - Dust accumulation management - Dust collector installation, including associated ductwork - Explosion control methods, including deflagration venting, explosion suppression and isolation Dust Hazards Analysis (DHA) 21
22 Combustible Powders Dust Hazard Analysis
Closed Systems for HPLCs Link to website: http://www.calpaclab.com/port-caps 23
24 Closed Connections for Equipment Exhaust
Day to Day Management MAQs - Tenant lease language - Number of Control Areas - % of a Control Area in ft 2 - Bar coding materials - Bar coding doorways - Real-time inventory by hazard class - FD spot-checking - Good MOC for Control Areas - Drawing records - Impact on user groups ability to operate - Judicious delineation of control areas - Penetrations, glazing, movement of fire barriers 25
Day to Day Management MAQs Hazardous Materials Expert Assistant (Version 6.2) - www.iccsafe.com - Physical & Health Hazard Classifications per IBC, IFC, NFPA - Need to set up Excel workbook and macros - Recommend Sax reference for materials not in database - Several tracking software packages 26
Chemical Reaction Hazards/Hydrogenation Hydrogen storage and use High pressure conditions Operating temperature? Flammable reaction solvent? Ni or Pt catalyst = pyrophoric liquid? Controls & interlocks Alarms/notifications Operator training & access 27
Isolation of Areas Handling Toxic APIs ASHRAE 62.1 Separation of Air Labs vs. Egress Corridors Fit for Purpose Review 28
29 Layers of Protection
30 Layers of Protection Hurricane Harvey AIChE Discussion Board
CO 2 Exposure Issues After carefully reviewing the record evidence submitted in response to OSHA's proposal for carbon dioxide, the Agency has determined that exposure limits of 10,000 ppm (8-hour TWA) and 30,000 ppm (15-minute STEL) are appropriate. Carbon dioxide is a colorless, odorless, noncombustible gas. CARBON DIOXIDE - Centers for Disease Control and Prevention cdc.gov/niosh/pel88/124-38.html 31
CO 2 Exposure Issues Super Critical Fluid Chromatography (SFC) - Utilizes CO 2 as the mobile phase - LCO 2 Dewars - LCO 2 Bulk Tanks & Piping Cell Culture Incubators - Small rooms? - Fit for purpose? Considerations: - Source volume: bulk, Dewar, or gas cylinder - Flow rate - Room volume - Rate of air change any recirc? - Detection/alarm 32
ODH - H 2 S Leak and Purge In Tunnels Summary 33 Crenshaw UG1 Hydrogen Sulfide Leak and Purge
527 CMR MA Comprehensive Fire Safety Code 60.8.2.9 Hazardous Process Category. Hazardous material processes shall be defined as follows: (1) Category 1..vessel with a capacity that is less than or equal to 2.5 gallons. (2) Category 2..vessel with capacity that is greater than 2.5 gallons but less than or equal to 60 gallons. (3) Category 3..vessel that is greater than 60 gallons but is less than or equal to 300 gallons.. or a process area that is classified as being a H Occupancy (4) Category 4..vessel with a capacity that is greater than 300 gallons and is not considered a Category 5 Process. (5) Category 5...vessel with a capacity that is equal or in excess of threshold quantities stated in 29 CFR 1910.119 or 40 CFR Part 68 and regulated by such standard. 34
Upcoming MassBio Forums October 12: Factoring in Human Factors: What You Don t Know Can Hurt You; FDD & MedDev October 18: Corporate Social Responsibility: Forprofit/Non-profit Partnership with Purpose; NP October 31: Going Virtual with CROs: Accelerating Product Development While Minimizing Organizational Scale; CRO/CMO