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Panasonic Biomedica Pharmaceutica Soutions Pharmaceutica Life Science Soutions Optimum preservation and incubation Top performance Word cass design 86ºC UtraLow Temperature Freezers 30ºC Biomedica Freezers 50ºC Cryogenic Freezers Pharmaceutica Refrigerators CO 2 Incubators ReachIn Incubators

Discovery starts with a dream. A dream to know who we are. A dream to better our ives... Behind every great discovery, there s the technoogy that made it a possibe. Introduction Within the pharmaceutica industry, Panasonic is renowned for stateoftheart engineering in core aboratory equipment. Purposebuit technoogy and appication specific designs ensure our products are of the highest quaity and durabiity. Partnering with Panasonic can provide a number of benefits to pharmaceutica companies. We are proud to provide the utimate and the most reiabe protection for your sampes, faciitating cuttingedge research in the fieds of medicine, pharmaceuticas and biotechnoogy. 2

Panasonic Biomedica Pharmaceutica Soutions Pharmaceutica Soutions Best storage temperature uniformity Innovative incubation Step into the word of vaidation What to ook for in an idea incubator? 86ºC ULTRALOW FREEZERS 30ºC BIOMEDICAL FREEZERS 6 8 4 50ºC CROGENIC FREEZERS 9 PHARMACEUTICAL REFRIGERATORS 2 CO 2 INCUBATORS 2 VALIDATION: PROCESS EFFICIENC: vaidation Offering a comprehensive range of vaidation services for efficiency Improved incubator technoogy for preventive contamination contro, faster decontamination a your compiance needs. and decreased experimenta downtime. COST SAVINGS: SAMPLE INTEGRIT: savings Energy efficient freezers for decreased operationa costs and integrity Preserve your highvaued sampes with optima temperature uniformity and stabe reiabe sampe storage. environmenta conditions. 3

VALIDATION Compete vaidation & quaification soutions Keeping up with evoving reguations that are constanty becoming stricter can be a daunting task. When it comes to your aboratory equipment it is important to know that it wi pass compiance checks and that the manufacturer has years of experience in vaidation training and services. Panasonic is a vertica component manufacturer that can provide turnkey soutions for vaidation and quaification in accordance with a current reguations and specific customer requirements and appications. Vaidation Soutions Turn key soutions avaiabe for: Utraow freezers Cryogenic freezers Medica freezers Pharmaceutica refrigerators Incubators Ovens Autocaves Environmenta test chambers Panasonic vaidation soutions Inhouse Third party Manufacturer Equipment experience Broad based Broad based Most Panasonic specific experience Up to date technica info Genera knowedge Genera knowedge Direct updates Unexpected service issues Time deay Time deay Iediate soutions Time consuming More prep. time More prep. time Most experience Knowedge of industry standards High eve Broad based Best appicabe knowedge 4

Panasonic Biomedica Pharmaceutica Soutions INSTALLATION AND OPERATIONAL QUALIFICATION (IOQ) Panasonic offers onsite vaidation of Panasonic manufactured equipment via Instaation and Operationa Protoco (IOQ). ) INSTALLATION QUALIFICATION (IQ): Verifies and documents the equipment instaation to be compiant with the manufacturer s requirements and specifications. 2) OPERATIONAL QUALIFICATION (OQ): Verifies and documents the fu functiona operation of the instaed equipment (as specified by Panasonic or other OEM suppied equipment). Temperature performance wi be mapped over a continuous 24hr period. Data produced wi be compared with manufacturer s pubished equipment specification. Product specific parameters such as the CO 2 /O 2, %RH, etc can be incuded within the reevant equipment IOQ protoco. 3) PROCESS QUALIFICATION (PQ): Usuay conducted and performed by the enduser as the equipment wi be in an environment where specific user conditions appy, i.e., the customer s actua production or product processing area. The PQ wi make reference to customer specific Standard Operation Procedures documents (SOPs). 4) TEMPERATURE MAPPING: Offered for customers wishing to verify actua equipment performance as instaed. This is aso avaiabe for nonpanasonic equipment. 5) FACTOR ACCEPTANCE TESTING (FAT): Indepth factory acceptance testing covers aarms, temperature and CO 2 stabiity, and temperature recovery. This service can be customised to SOPs. Panasonic vaidation services by mode Temp. CO 2 O 2 %RH Lighting Pressure (Lux/Par) Vaidation by Mode 4 MDF50 ºC Freezers 4 MDF86 ºC Freezers 4 MDF30 ºC Freezers 4 MBR Bood Bank 4 Refrigerators MPR Pharmaceutica Refrigerators 4 MIR Incubator Series 4 MCO CO 2 &O 2 /CO 2 Incubators 4 4 4 4 MLS Top Loading Autocaves 4 4 MLR Environmenta Test 4 4 4 Chamber CBS Standard LN 2 Freezers 4 THERMAL VALIDATION Panasonic aso provides a therma vaidation soution specificay designed to conform with new FDA data protection guideines (2 CFR Part ) and meet internationa and European cgmp requirements for inspection of pharmaceutica, biotechnoogy, and medica device (EN285, EN554), manufacturing. SERVICES Measurement of temperature profies, CO 2, O 2, %RH, ighting, and pressure Reduced Setup Time Automatic Sensor Caibration Data Anaysis System Design INSTALLATION, CALIBRATION & MAINTENANCE In order to trace and keep an accurate record of performance of your ab equipment, a reguar schedue of caibration and preventive maintenance is required. Panasonic offers the foowing services: Coissioning/Setup/Instaation Caibration Onsite Protoco Execution Warranty response Factory Acceptance Testing Custom Vaidation Protocos 5

86ºC ULTRALOW TEMPERATURE FREEZERS (VIP DUAL COOL, VIP ECO) EFFICIENC IMPROVE ENERG EFFICIENC AND SAMPLE INTEGRIT At Panasonic, we have designed freezers that are both efficient and reiabe without compromising performance. A unique heat exchanger technoogy decreases energy usage and makes our freezers % more efficient than eading competitors (Fig A). The VIP ECO Series aso uses vacuum insuation pane (VIP) technoogy reducing wa thickness by around 50%, achieving 30% more storage capacity, and reducing the average cost per box stored (Fig B). Leveraging the power of natura hydrocarbon refrigerants aso aows the VIP ECO freezers to use smaer compressors, due to their greater efficiency. The natura hydrocarbon refrigerants combined with VIP insuation technoogy aso hep the environment by reducing the carbon footprint with up to % fewer emissions (Fig C). savings HC natura refrigerants VIP + Pus + vacuum insuation Twin Guard dua coo technoogy Reduce overa operationa costs FIGURE A FIGURE B FIGURE C Power consumption by capacity. kwh / day / 2 box capacity Tota annua operating cost by capacity. Euro's / 2" box capacity Annua CO 2 eissions by capacity. kwh / day / 2 box capacity 0.04 0.03 0.02 0.0 0 0.022 0.03 0.038 Euros / 2 box capacity 5.00 4.00 3.00 2.00.00 0.00.9.69 2.08 Panasonic Brand A Brand B Panasonic Brand A Brand B Panasonic Brand A Brand B Kg / 2 box capacity 5 4 3 2 0 2.79 4.02 4.87 Over % more efficient Over % reduction in cost Over % ower emissions (A Panasonic numbers represent MDFDU700VH) 6 Typica data individua units may vary and power consumption wi depend on oading and operating conditions. Freezer set point 80ºC, ambient temperature 2226ºC, unoaded, 230V 50Hz power suppy, 0.5 Euros/kWh. European emissions of 0.3509 CO 2 per kwh Internationa Energy Agency (IEA).

Panasonic Biomedica Pharmaceutica Soutions SAMPLE INTEGRIT PRESERVE SAMPLE INTEGRIT FOR BETTER END PRODUCTS Uneven interior temperatures can ead to a oss in sampe integrity. Freezers with uniform, stabe temperatures and quick recovery times provide the best protection for your sampes, ensuring reiabe preservation whie guarding against degradation. FIGURE 2B LOW FREEZERS (VIP DUAL COOL, VIP ECO) VIP DUAL COOL FIGURE 2A MDFU700VX; 9 POINT TEMPERATURE MAPPING The Panasonic VIP Dua Coo Series utraow freezers fufi the pharmaceutica industry s demand for the most secure, ongterm storage of highvaued materias whie sti maintaining exceent temperature uniformity and energy efficiency. Two independent refrigeration systems offer utimate protection, even in the event of one compressor faiing. The appication specific compressors combined with unique vacuum insuation panes (VIP) aso provide rapid temperature recovery and maintain superior uniformity at a points within the freezer. Nine point mapping tests show that temperature uniformity surpasses the industry standard of +/5ºC, heping meet reguatory compiance for vaidation. (Fig 2A) RELEVANT APPLICATIONS SAMPLE OR LABORATOR CHARACTERISTICS > For sampes that are highy sensitive to temperature fuctuations or uneven temperature distribution within the freezer. > Vauabe sampes. BENEFIT OF DUAL COOL FREEZERS > Dua Coo technoogy greaty extends the critica time necessary to react in the event of a mechanica faiure. > Enhanced temperature uniformity, toptobottom, fronttoback, assures sampe stabiity at a inventory ocations. > Irrepaceabe sampes. > Longitudina studies and ongoing research. > Restricted access aboratories where serviceabiity is imited. 7

30ºC &ºC BIOMEDICAL FREEZERS (MDFU73M, MDFU542, MDFMU500H) SAMPLE INTEGRIT 2 HIGH PERFORMANCE FREEZERS WITH OPTIMAL TEMPERATURE UNIFORMIT Panasonic biomedica freezers are designed for ong or intermediateterm storage at temperatures as ow as ºC. Constructed with timetested aboratory and cinicagrade refrigeration systems, these freezers are idea for the storage of a wide variety of sampes incuding enzymes, bioogics and medicines. integrity HC natura refrigerants IC+ inverter controed savings 2 Microprocessor contros: Configure temperature setpoints, aarms, monitoring, and diagnostic functions through a digita dispay. Sampe storage freezer bins: For a Panasonic 30ºC & ºC freezers a wide variety of storage soutions are avaiabe. From sheves to racks and / or bins. Rapid temperature recovery maintains uniformity The rapid pudown speeds of Panasonic Biomedica freezers ensures that the effects of door openings are minimized. Uniform temperatures are maintained throughout the chamber through direct cooing with a fu cod wa design. The inner chamber temperature offers outstanding uniformity and stabiity without temperature spikes. The uniform, stabe and reiabe temperatures provided by Panasonic Biomedica freezers are perfect for preservation of enzymes and bioogics. 8

Panasonic Biomedica Pharmaceutica Soutions 50ºC CROGENIC FREEZERS (MDFC256VAN) SAMPLE INTEGRIT TEMPERATURE UNIFORMIT FOR LONGTERM STORAGE Panasonic cryogenic freezers are weknown for maintaining uniform temperatures at 50ºC for the reiabe, ongterm preservation of ces and tissue. With thin vacuum insuation pane (VIP) was, the cryogenic freezer can achieve more storage capacity than a conventionay insuated freezer without increasing footprint, whie aso maintaining superior temperature uniformity. VIP + Pus + vacuum insuation integrity savings Cryogenic freezers promote sampe stabiity Recrystaization mechanism 80ºC Hexagona crysta A uniformity of +/5ºC in Panasonic mechanicay refrigerated cryogenic freezers is far superior to the toptobottom temperature uniformity provided by iquid nitrogen vapour phase storage, without the concern of crosscontamination often associated with iquid nitrogen (iquid phase storage). 30ºC Recrystaization Point 50ºC Cubic crysta Amorphous ice crysta Liquid Nitrogen freezer (Traditiona vapour phase) Panasonic MDFC25VAN mechanicay refrigerated cryogenic freezer Comparison of temperature distribution in a iquid nitrogen freezer (vapour phase) and Panasonic s MDFC256VAN mechanicay 4 cm 72ºC From LN 2 surface 8ºC 80ºC 62ºC 57ºC 46ºC 46ºC 46ºC 47ºC Center of Chamber ine 49ºC 49ºC refrigerated cryogenic freezer. The graph shows temperatures at different ocations within the chamber. This data demonstrates that 00% of the MDFC256VAN storage space maintains uniform storage temperatures safey beow 30ºC, whie temperature in the LN2 vapour system is dependent on storage ocation. 9

LIQUID NITROGEN TANKS (DR STORAGE FREEZERS) SAMPLE INTEGRIT PRESERVE SAMPLES WITH LIQUID NITROGEN V3000AB/C Panasonic aso offers Isotherma Carouse Liquid Nitrogen Vapor Storage system which combines the innovative 90ºC isotherma design with a sma opening and an interior rotating carouse. The system has a sma opening which heps to reduce iquid nitrogen consumption, ensures the id is both ightweight and userfriendy and keeps temperatures in the freezer consistenty ow. With improved operation and design, the system provides superior temperature uniformity for maximum sampe preservation. In addition, a unique patented iquid nitrogen jacket aows sampes to stay coo without coming into contact with iquid nitrogen. Standard square rack configuration V500AB V5000ABEH/C Key advantages Vacuum insuation Temperature controed storage area Liquid nitrogen enveope ) Dry storage freezer. 2) Unique patented iquid nitrogen jacket aows for no iquid in sampe storage space and improves user safety. 3) Reduced exposure to room temperatures. 4) Superior temperature uniformity. 5) No risk of crosscontamination through iquid nitrogen contact. 6) Carouse is rotated from outside of the freezer eiminating risk of injury or temperature fuctuations. 7) Manufactured to ISO 3485 standards. 0

Panasonic Biomedica Pharmaceutica Soutions PHARMACEUTICAL REFRIGERATORS SAMPLE INTEGRIT SUPERIOR TEMPERATURE UNIFORMIT THROUGHOUT THE INTERIOR CHAMBER Panasonic refrigerators are speciay designed to compy with pharmaceutica reguations. Exceptiona temperature uniformity is paired with easy caibration access to meet critica vaidated storage reguations. A thermistor sensor monitors temperature inside the chamber, whie microprocessor contros ensure that an accurate set temperature is maintained. Even with frequent door openings, the circuation fan provides rapid temperature recovery for a stabe preservation environment unaffected by ambient temperature. integrity savings Defrost cyce Defrosting is performed automaticay during compressor off cyces by sensing ice accumuation. This way defrosting is performed ony when required, further protecting your sampes against unnecessary temperature fuctuations (Fig A). FIGURE A

CO 2 INCUBATORS (MCO70AIC, MCO70AICUV, MCO70AICUVH) PROCESS EFFICIENC With the increasing need to quicky identify new research opportunities and verify the importance of a certain drug or therapeutic pathway, it is no surprise pharmaceutica companies are ooking for ways to improve efficiency. At Panasonic, we offer innovative technoogy that aows for faster turnaround and introduction of your drug to the market. dua IR sensor incu copper aoy stainess Safe Ce UV Air HO 2 2 Jacket decontamination Consistent and uniform environment for ce growth PROACTIVE CONTAMINATION CONTROL Proactive contamination contro is achieved through a combination of a copperenriched stainess stee interior (incusafe ) and an utravioet ight. The copperenriched stainess stee interior surface combines the germicida properties of copper and the anticorrosive nature of stainess stee. FIGURE A Panasonic combines a patented Direct Heat and Air Jacket heating system that surrounds the inner was with a natura convection airfow to achieve exceptiona temperature uniformity within the chamber. Combined with a dua infrared sensor for unprecedented contro over CO 2 gas eves, the Panasonic incubator provides a stabe environment for ce growth even with mutipe door openings daiy. InCu safe Interiors InCu safe fights off surface contamination and does not corrode ike soid copper surfaces Easier visibiity with better ooking interior Standard feature with Panasonic Incubators at no additiona cost Pure Copper Interiors Wi corrode over time (humid environment turns it into green cupric oxide, which may prove to be etha to ces) Contamination difficut to detect due to ess visibiity More expensive and difficut to maintain 2

Panasonic Biomedica Pharmaceutica Soutions PROCESS EFFICIENC ULTRAVIOLET LIGHT AND COPPERENRICHED STAINLESS STEEL INTERIOR REDUCE THE CHANCE OF CONTAMINATION To further prevent contamination in the incubator, Panasonic impemented a unique SafeCe utravioet (UV) system. SafeCe UV technoogy uses a prograabe utravioet amp that steriises air and the humidity water pan without affecting ce cutures. It inhibits the growth of a contaminants incuding mycopasma without costy HEPA fiter air scrubbers which are ineffective on partices ess than 0.3 microns. FIGURE 2A Airfow UV Light RAPID HDROGEN PEROXIDE DECONTAMINATION REDUCES EXPERIMENTAL DOWNTIME With Panasonic s hydrogen peroxide technoogy, achieve compete decontamination 8X faster than conventiona high heat methods (Fig 2B). The cyce competes in just 3 hours incuding the post utravioet conversion of H 2 O 2 into water and oxygen for easy ceanup (Fig 2C). This aows researchers to get back to their ce cuture work the same day and aows companies to achieve faster drug discoveries. FIGURE 2B FIGURE 2C H O + 2 O2 SafeCe UV HARMLESS CELL DAMAGE DNA DAMAGE CELL DAMAGE Remaining H 2O 2and Hydroxy radicas Unstabe interna environment H O Contaminant DEATH O H 2 OH SafeCe UV H O separates 2 2 in two Hydroxy radicas OH + OH H O can obtain an 2 2 from a organic source Decontamination time Brand B CONTAMINANT OH initiates chain reaction of eectron steaing Brand A Panasonic 3hrs 2hrs 24hrs 3

CO 2 INCUBATORS (MCO70AIC, MCO70AICUV, MCO70AICUVH) PROCESS EFFICIENC We have designed our incubators with ease of use and efficiency in mind. By deivering a user friendy ce cuture incubator with rapid systems and processes Panasonic can hep make your work as simpe as possibe. More space for more cutures In a aboratory environment it is important to make the most of a the space avaiabe. With new integrated shef supports the Panasonic MCO70AIC CO 2 incubators provide space for up to 25% more cuture vesses.* * Compared to previous Panasonic 70 itre CO 2 incubators. USB PORT Optimise ce cuture protocos and adhere to standard operating procedures by convenienty transferring data to a USB memory stick to pass on to a PC. Logged parameters incude chamber temperature, CO 2 eve, door open status and aarms. INTEGRATED SHELF SUPPORTS The MCO70AIC CO 2 incubator has ess removabe parts than the traditiona incubator. Its new interior design with integrated shef supports makes it easier to cean which saves vauabe time and reduces risk of contamination. 4

Panasonic Biomedica Pharmaceutica Soutions PROCESS EFFICIENC MCO80IC REACHIN INCUBATOR Sometimes your pharmaceutica research may ca for arge scae processing. With Panasonic s MCO80IC arge scae reachin incubator, take your ce cuture needs to greater eves by growing more ce ines at once. Improved decontamination technoogies (24/7 active bacround contamination contro with optiona UV ight) and CO 2 and temperature sensors aow for faster turnaround and higher ce yied. HEATED AND COOLED INCUBATORS Quaity contro and testing is an important aspect of pharmaceutica deveopment. With Panasonic s heated and cooed incubators, achieve optima temperature configuration for a variety of protocos, incuding QA/QC, industria and chemica testing. 5

AN INTEGRATED SOLUTION FOR OUR PHARMACEUTICAL LABORATOR Panasonic s soution to optimizing the pharmaceutica aboratory aows for reiabe vaidation, improved efficiency, and reduced costs. Our utraow freezers, pharmaceutica refrigerators and incubators form an integrated soution to hep meet the strictest reguations in the pharmaceutica industry. GROUP VIP Pro 50ºC Chest Freezers Cassic Pro 52ºC Chest Freezers Characteristics Longterm storage beow recrystaisation point Safe storage without risk of cross contamination Reiabe Panasonic Coo Safe compressors Low operationa costs Longterm storage beow recrystaisation point Safe storage without risk of cross contamination Reiabe Panasonic Coo Safe compressors Low operationa costs PUF = Rigid poyurethane foamed insuation V = Visua aarm B = Buzzer aarm R = Remote aarm MODEL MDFC256VANPE MDF56PE MDF56ATNPE Dimensions Externa dimensions (W x D x H) ) Interna dimensions (W x D x H) Voume Capacity Net weight (approx) Performance Cooing performance 2) Temperature setting range Temperature contro range 2) Contro Controer Dispay Temperature sensor Refrigeration Refrigeration system Highstage compressor Highstage refrigerant Lowstage compressor Lowstage refrigerant Insuation materia Insuation thickness Construction Exterior materia Interior materia Outer id ock Inner id Max. oad tota Access port position diameter Casters Aarms Power faiure High temperature Low temperature Fiter Lid open Eectrica and noise Leve Power suppy Noise eve 3) Options Liquid CO 2 backup Liquid N 2 backup Temperature recorders Continuous strip type Chart paper Ink pen Recorder housing (if required) RS485 interface modue itres 2 boxes º C º C º C W W Ø db 730 x 765 x 00 760 x 495 x 65 23 50 38 50 25 ~ 52 25 ~ 50 LCD Pt000 Cascade with autocascade owstage PUF / VIP PLUS 35 2 207 Right 6 (3 eveing feet) VBR VBR VBR VB VB 5 Suppied as standard MTR55HPW RP55PW DF38FPPW MDFS3050PW MTR480PW Microprocessor, nonvoatie memory 00 HFC 00 HFC mixed Painted stee Auminium 265 230V 50Hz singe phase CVKAT2PW 4,5) CVKATN2PW 4) MTR55HPW RP55PW DF38FPPW 0 x 800 x 945 500 x 450 x 572 28 8 52 25 ~ 55 30 ~ 52 LED Pt00 Cascade PUF 75 300 Left 6 (2 eveing feet) VBR VBR VB 6 272 Suppied as standard Suppied as standard RP55PW DF38FPPW 6 Notes: ) Exterior dimensions of main cabinet ony, excuding hande and other externa projections See dimensions drawings on website for fu detais 2) Air temperature measured at freezer centre, ambient temperature +30ºC, no oad 3) Nomina vaue. Bacround noise 20dB. 4) Requires recorder MTR55HPW 5) CVKAPW may aso be used Appearance and specifications are subject to change without notice.

Panasonic Biomedica Pharmaceutica Soutions GROUP Isotherma 90ºC Dry Storage Freezers Outstanding temperature uniformity No LN2 in sampe storage area No cross contamination Certified MDD 93/42/EEC:993 Cass IIA ** Capacity is subject to rack type MODEL Liquid nitrogen capacity Dimensions Externa dimensions (WxDxH) Usabe interior height Usabe interior diameter Weight empty Weight fu Maximum capacity Max. via capacity (2m)** Max. bood bag capacity (50m)** itres V500AB 30 660 x 939 x 43 736 534 48 74 900 434 V3000AB 70 939 x 29 x 206 736 787 272 327 2200 20 V3000ABEH 89 939 x 29 x 473 9 787 295 367 25500 280 V5000AB 93 29 x 37x 320 736 06 425 500 300 936 V5000ABEH 29 x 37 x 473 864 06 453 566 46500 2208 GROUP Isotherma Carouse Outstanding temperature uniformity No LN2 in sampe storage area No cross contamination Certified MDD 93/42/EEC:993 Cass IIA MODEL V3000AB/C V3000ABEH/C V5000AB/C V5000ABEH/C ** Capacity is subject to rack type Liquid nitrogen capacity Dimensions Externa dimensions (WxDxH) Usabe interior height Usabe interior diameter Weight empty Weight fu Maximum capacity Max. via capacity (2m)** Max. bood bag capacity (50m)** itres 70 939 x 29 x 30 686 736 272 327 6800 852 89 939 x 29 x 384 889 736 288 36 2000 36 93 94 x 372 x 257 737 978 425 499 360 722 94 x 372 x 384 83 978 452 566 42000 968 Appearance and specifications are subject to change without notice. 7

AN INTEGRATED SOLUTION FOR OUR PHARMACEUTICAL LABORATOR GROUP VIP Dua Coo 86ºC Upright Freezers VIP Eco 86ºC Upright Freezers Characteristics Dua independent refrigeration system for extra security Vacuum Insuation Panes for optima uniformity and reduced footprint LCD screen with graphica dispay Optima energy efficiency with unique heat exchanger technoogy Vacuum Insuation Panes for optima uniformity and reduced footprint PUF = Rigid poyurethane foamed insuation V = Visua aarm B = Buzzer aarm R = Remote aarm MODEL MDFU500VXPE MDFU700VXPE MDFDU500VHPE MDFDU700VHPE Dimensions Externa dimensions (WxDxH) ) Interna dimensions (WxDxH) Voume Capacity Net weight (approx) Performance Cooing performance 2) Temperature setting range Temperature contro range 2) Contro Controer Dispay Temperature sensor Refrigeration Refrigeration system Highstage compressor Highstage refrigerant Lowstage compressor Lowstage refrigerant Insuation materia Insuation thickness Construction Exterior materia Interior materia Outer door ock Inner door Sheves Max. oad per shef Max. oad tota Vacuum reease port Access port position diameter Casters Aarms Power faiure High temperature Low temperature Fiter Door open Eectrica and noise eve Power suppy Noise eve 3) Options Liquid CO 2 backup Liquid N 2 backup Temperature recorders Circuar type Chart paper Ink pen Continuous strip type Chart paper Ink pen Recorder housing RS485 interface modue Drawers Sma inner door kit itres 2 boxes º C º C º C W W Ø db set of 2 770 x 870 x 990 630 x 600 x 380 59 352 320 MDF50RPW (max ) MDF5IDPW (max 2) 5) 86 50 ~ 90 50 ~ 86 00 x 870 x 200 870 x 600 x 0 728 528 375 Microprocessor nonvoatie memory LCD Pt000 Independent DuaCooing 2 x 00 HFC mixed PUF / VIP PLUS 70 Painted stee Painted stee 2 (insuated) 3 50 50 3 Back/bottom x 2 7 4 (2 eveing feet) VBR VBR VBR Fiteress design VB 230V 50Hz singe phase 53 CVKUB2PW CVKUBN2PW MTRG85CPE RPG85PW PGRPW MTR85HPW RP85PW DF38FPPW MDFS3085PW MTR480PW MDF7IDPW (max 2) 5) 770 x 870 x 990 630 x 600 x 0 526 352 29 MDF50RPW (max ) MDF5IDPW (max 2) 5) 86 50 ~ 90 50 ~ 86 00 x 870 x 990 870 x 600 x 0 728 528 334 Microprocessor nonvoatie memory LED Pt000 Cascade 750 HC 750 HC PUF / VIP PLUS 70 Painted stee Painted stee 2 (insuated) 3 50 50 2 Back / bottom 7 4 (2 eveing feet) VBR VBR VBR VB VB 230V 50Hz singe phase 52 CVKUB2PW CVKUBN2PW MTRG85CPE 4) RPG85PW PGRPW MTR85HPW 4) RP85PW DF38FPPW MDFS3085PW MTR480PW MDF7IDPW (max 2) 5) 8 Notes: ) Exterior dimensions of main cabinet ony, excuding hande and other externa projections See dimensions drawings on website for fu detais 2) Air temperature measured at freezer centre, ambient temperature +30 C, no oad 3) Nomina vaue. Bacround noise 20dB 4) Requires Sensor MTRDU700SFPW (KMDUP0SFW) 5) Instaation of sma inner door kit may affect usabe storage capacity. Appearance and specification are subject to change without notice.

Panasonic Biomedica Pharmaceutica Soutions GROUP Biomedica Pro ºC Upright Freezers Biomedica Pro 30ºC Upright Freezers Characteristics Outstanding reiabiity and performance Avaiabe for a wide variety of storage Exceent safety features Maximum capacity in minimum instaation space Outstanding reiabiity and performance Avaiabe for a wide variety of storage Exceent safety features Maximum capacity in minimum instaation space PUF = Rigid poyurethane foamed insuation V = Visua aarm B = Buzzer aarm R = Remote aarm MODEL MDFU443PE MDFU542PE MDFU334PE MDFU532PE Dimensions Externa dimensions (W x D x H) ) Interna dimensions (W x D x H) Voume Capacity Net weight (approx) Performance Cooing performance Temperature setting range Temperature contro range Contro Controer Dispay Temperature sensor Refrigeration Cooing method Compressor Refrigerant Insuation materia Insuation thickness Construction Exterior materia Interior materia Outer door Outer door ock Sheves Containers / baskets Max. oad per shef/container/basket Max. oad tota Access port position diameter Casters Aarms Power faiure High temperature Low temperature Fiter Door open Eectrica and noise eve Power suppy Noise eve 4) Options Temperature recorders Circuar type Chart paper Ink pen Recorder housing Continuous strip type Chart paper Recorder housing RS485 interface modue itres 2 boxes ºC ºC ºC W Ø db 800 x 832 x 80 6 x 65 x 090 426 256 23 3) 5 ~ 44 5 ~ 2) Microprocessor, nonvoatie memory LED Thermistor Cascade + forced air circuation H:0/L:750 HFC PUF 80 Styro resin 5 50 200 Left VB VB Painted stee 4 (2 eveing feet) VBR VBR VBR 804 x 772 x 802 658 x 607 x 272 482 224 34 2) 8 ~ 45 20 ~ 3) Direct 0 70 Stainess stee 2 4 (fixed) 4/6/0 30 00 Back 30 230V 50Hz singe phase 5 42 MTR85HPW RPG85PW DF38FPPW MTR5LHPE RPPW MPRS30PW MTR480PW MTRG85CPE RPG85PW PGRPW MPRS7PW MTR5LHPE RPPW MPRS30PW MTR480PW 64 x 709 x 620 490 x 486 x 290 274 50 8 30 2) 8 ~ 35 20~ 30 2) Microprocessor, nonvoatie memory LED Thermistor 200 60 4/0/ 80 Left Direct HFC PUF Painted stee Styro resin 4 (fixed) 30 30 4 (2 eveing feet) VBR VBR VBR 230V 50Hz singe phase 37 MTRG85CPE RPG85PW PGRPW MDFS7TPW MTR5LHPE RPPW 804 x 772 x 802 658 x 607 x 272 482 224 34 0 70 2 4/6/0 00 Back MTRG85CPE RPG85PW PGRPW MPRS7PW MTR5LHPE RPPW MPRS30PW MTR480PW Appearance and specification are subject to change without notice. Notes: ) Exterior dimensions of main cabinet ony, excuding hande and other externa projections See dimensions drawings on website for fu detais 2) Air temperature measured at freezer centre, ambient temperature +35ºC, no oad 3) Air temperature measured at freezer centre, ambient temperature +30ºC, no oad 4) Nomina vaue Bacround noise 20dB 9

AN INTEGRATED SOLUTION FOR OUR PHARMACEUTICAL LABORATOR GROUP Biomedica Eco 30ºC Upright Freezers Biomedica Pro 30ºC Upright Freezers Characteristics Improved Temperature Uniformity Inverter controed compressors for improved performance Hydrocarbon refrigerants for increased energy efficiency Large capacity biomedica freezer Manua defrost prevents temperature spikes Fexibe inventory soutions PUF = Rigid poyurethane foamed insuation V = Visua aarm B = Buzzer aarm R = Remote aarm MODEL MDFMU300HPE MDFMU500HPE MDFU73MPE Dimensions Externa dimensions (W x D x H) ) Interna dimensions (W x D x H) Voume Capacity Net weight (approx) Performance Cooing performance Temperature setting range Temperature contro range Contro Controer Dispay Temperature sensor Refrigeration Cooing method Compressor Refrigerant Insuation materia Insuation thickness Construction Exterior materia Interior materia Outer door Outer door ock Sheves Containers / baskets Max. oad per shef / container / basket Max. oad tota Access port position diameter Casters Aarms Power faiure High temperature Low temperature Fiter Door open Eectrica and noise eve Power suppy Noise eve 4) Options Storage systems Temperature recorders Circuar type Chart paper Ink pen Recorder housing Continuous strip type Chart paper Recorder housing RS485 interface modue Externa mounting power faiure aarm itres 2 boxes ºC ºC ºC W Ø db 60 x 598 x 620 490 x 486 x 290 274 50 76 60 ABS resin 4/0/ 30 80 Left MTRG85CPE RPG85PW PGRPW MPRS470TPW MTR5LHPE RPPW 30 2) 8 ~ 35 20 ~ 30 2) 800 x 772 x 802 658 x 607 x 272 482 224 24 Microprocessor, nonvoatie memory LED Thermistor Direct 250 (inverter contro) HC PUF Painted stee 4 (fixed) 30 4 (2 eveing feet) VBR (Optiona) VB(R 3 ) VB(R 3 ) 230V 50Hz singe phase MTR480PW 5) MPR48BPW 5) 70 Styro resin 2 4/6/0 U:30/L:20 00 Back MTRG85CPE RPG85PW PGRPW MPRS7PW MTR5LHPE RPPW MPRS30PW 770 x 830 x 955 650 x 700 x 520 690 384 52 30 2) 8 ~ 35 20~ 30 2) Microprocessor, nonvoatie memory LED Thermistor Direct 0 HFC PUF 60 Painted stee Painted stee 4 (fixed) Optiona 50 200 Left 30 4 (2 eveing feet) VBR VBR VBR VB 230V 50Hz singe phase 42 MDFT07SCSW, Set of 2 containers MDFT07STSW, Set of 3 sheves MTRG85CSE RPG85SW PGRSW MPRS7SW MTR5LHPE RPSW MPRS30SW Notes: ) Exterior dimensions of main cabinet ony, excuding hande and other externa projections See dimensions drawings on website for fu detais 2) Air temperature measured at freezer centre, ambient temperature +30ºC, no oad 3) Remote aarm comes with optiona power faiure aarm MPR48BPW 4) Nomina vaue Bacround noise 20dB 5) Requires MPR48BPW Appearance and specification are subject to change without notice. 20

Panasonic Biomedica Pharmaceutica Soutions GROUP Characteristics Refrigerator Series Extremey stabe and reiabe temperatures Speedy and powerfu refrigeration Adjustabe sheves or pu out drawers Easytomanage ay out PUF = Rigid poyurethane foamed insuation V = Visua aarm B = Buzzer aarm R = Remote aarm MODEL MPR72PE MPR72RPE MPR4PE MPR4RPE Dimensions Externa dimensions (W x D x H) ) Interna dimensions (W x D x H) Voume Net weight (approx) Performance Temperature contro range 2) Contro Controer Dispay Temperature sensor Refrigeration Cooing method Defrost method Refrigerant Insuation Construction Exterior materia Interior materia Outer door itres º C 684 74 770 x 830 x 955 650 x 70 x 500 2 ~ 23 Microprocessor LED Thermistor 67 93 Forced coo air circuation Forced type (cyce defrost), fuy automatic HFC PUF Painted stee Painted stee door, doube pane gass, sef cosing 364 248 4 x 830 x 950 320 x 70 x 500 2 ~ 23 Microprocessor LED Thermistor 359 287 Forced coo air circuation Forced type (cyce defrost), fuy automatic HFC PUF Painted stee Painted stee 2 doors, doube pane gass, sef cosing Outer door ock Sheves Max. oad per shef Drawers 4 wire sheves, poyethyenecoated 50 5 coated stee drawers 8 wire sheves, poyethyenecoated 0 coated stee drawers Max. oad per drawer Max. oad tota Access port position diameter Casters Interior ight Aarms Power faiure High temperature Low temperature Door open Eectrica and noise eve Power suppy Noise eve 3) Options Temperature recorders Temperature chart recorder Chart paper Recorder housing Circuar type Chart paper Ink pen Recorder housing RS485 interface modue Externa mounting power faiure aarm Ø db 200 3 Left/right/top 30 4 Fuorescent VBR (Optiona) VBR VBR VB 230V 50Hz singe phase 4 MTR062LHPE RP06PW MPRS30PW MTRG04CPE RPG04PW PGRPW MPRS7PW MTR480PW 4) MPR48BPW (VB) 5) 200 320 3 Left/right/top 30 4 Fuorescent VBR (Optiona) VBR VBR VB 230V 50Hz singe phase 42 MTR062LHPE RP06PW MPRS30PW MTRG04CPE RPG04PW PGRPW MPRS7PW MTR480PW 4) MPR48BPW (VB) 5) 0 Appearance and specifications are subject to change without notice. Notes: ) Exterior dimensions of main cabinet ony, excuding hande and other externa projections See dimensions drawings on website for fu detais 2) Air temperature measured at refrigerator centre, ambient temperature +30ºC, no oad. 3) Nomina vaue Bacround noise 20dB 4) Requires MPR48BPW or MPR48BPW 5) MPR48BPW can aso be used 2

AN INTEGRATED SOLUTION FOR OUR PHARMACEUTICAL LABORATOR GROUP PUF = Rigid poyurethane foamed insuation V = Visua aarm B = Buzzer aarm R = Remote aarm CO 2 incubators 24/7 Active bacround contamination contro Superior temperature uniformity with Direct heat and Air jacket system 8X faster incubator decontamination with H 2 O 2 Large capacity 24/7 Active bacround contamination contro MODEL MCO70AICPE MCO70AICUVPE MCO70AICUVHPE MCO80ICPE Dimensions Externa dimensions (WxDxH) ) Interna dimensions (WxDxH) Voume Net weight (approx) Performance Temperature contro range and fuctuation Temperature uniformity 2) CO 2 contro range and fuctuation O 2 contro range and fuctuation Humidity eve and fuctuation Contro Temperature sensor CO 2 sensor O 2 sensor Dispay Construction Exterior materia Interior materia Insuation materia DHA heating system Outer door Outer door ock Reversibe door Inner door Sheves Max. oad per shef Max. tota oad Max. shef capacity Access port position diameter Aarms Power faiure Out of temperature setting High temperature Out of CO 2 setting Water eve Door open Eectrica and noise eve Power suppy Frequency Noise eve 3) Options SafeCe UV system H 2 O 2 decontamination board Eectric door ock with password H 2 O 2 vapour generator H 2 O 2 reagent, pack of 6 bottes Mutipe inner doors CO 2 gas pressure reguator Automatic CO 2 cyinder changeover system Semiautomatic one point gas caibration kit InCu safe shef (and brackets if required) InCu safe haf tray system Doube stacking bracket * Stacking pate * Stacking kit Roer base Roer botte rack mounting kit Automatic water suppy system kit Optiona counication systems 5) Ethernet interface (LAN) Digita interface (RS232C/RS485) Anaogue interface (420mA) itres C C % % %RH Ø V Hz db option MCO70UVSPE 4) MCO70HBPE 4) MCO70ELPW 4) 620 x 70 x 900 490 x 523 x 665 65 80 AT +5 ~ +50, ±0. ±0.25 0 ~ 20, ±0.5 95, ±5 Thermistor Dua IR LCD touch screen Painted stee (rear cover not painted) SS copper aoyed Extruded poystyrene option standard 4 7 20 0 Rear 30 R VBR VBR VBR VB 230 50 29 standard MCO70HBPE 4) MCO70ELPW 4) MCOHPPW 4) MCOH2O2PE MCO70IDPW MCO00LPW MCO2GCPW MCOSGPW MCO70STPW MCO25STPW MCO70PSPW* MCO70SBPW* MCO70RBPW MTRL03PW MTR480PW MCO420MAPW standard standard standard 986 x 853 x 20 806 x 693 x 524 85 275 AT +5 to 50 (AT; 20ºC to 35ºC) ±0.5 0 ~ 20, ±0.5 Norma mode; >80% R.H., High mode; > 90% R.H. Thermistor IR LED Painted stee SS copper aoyed PUF N (aminar airfow) doube paned gass N Option 5 30 50 5 2 Left and right hand side R VBR VBR VBR V V 230 50 33 MCO80UVSPE MCO80IDPW (5 sma doors) MCO00LPW MCO80GCPW MCO80STPW MCO80RBSPW MCO80ASPW MTR480PW MCO420MAPW 22 Appearance and specifications are subject to change without notice.

Panasonic Biomedica Pharmaceutica Soutions Mutigas incubators CO 2 reachin incubator GROUP PUF = Rigid poyurethane foamed insuation V = Visua aarm B = Buzzer aarm R = Remote aarm Prograabe cooed incubators Optima temperature configuration Refined aarm and security systems Prograabe operation of time and temperature MODEL MIR54PE MIR254PE MIR554PE Dimensions Externa dimensions (WxDxH) ) Interna dimensions (WxDxH) Voume Net weight (approx) Performance Temp contro range and fuctuation Temperature uniformity Performance ambient temperature Contro Temperature sensor Refrigeration Insuation materia Insuation thickness Compressor Refrigerant Cooing method Construction Exterior materia Interior materia Outer door Outer door ock Reversibe door Inner door Sheves Max. oad per shef Max. tota oad Access port position diameter Interior fuorescent amp Aarms Power faiure High temperature Low temperature Door open Eectrica and noise eve Power suppy Frequency Noise eve 3) Options Stacking kit Door padock bracket Additiona iumination kit Inner doors Door window banking pate Optiona counication systems Ethernet interface (LAN) Digita interface (RS232C/RS485) itres C C C W Ø, W V Hz db 700 x 580 x 08 620 x 368 x 555 23 78 50 R34a MIRLP option N 3 20 6 eft side 230 50 4 MIRS54SBPW MIRLPPW MIRL5PE MIR54BPPW 700 x 580 x 68 620 x 368 x 088 238 08 PUF 250 R4a Forced air circuation Painted stee SS SUS304 MIRLP option N 5 20 00 eft side, 5, with MIRL5PE 2) option 230 50 44 MIRLPPW MIRL5PE MIR254BPPW MTRL03PW MTR480PW 800 x 832 x 80 6 x 550 x 60 6 95 0 ~ +60 (AT; +5 ~ +35, no oad), ±0.2 with Heater PID contro (SV 50), ±.5 with Compressor contro (SV 5), PID contro: 7 C above AT for MIR54/254; 0 C above AT for MIR554 ±0.5 SV (35) 20, no oad Thermistor VBR VBR VB 80 250 R4A N 2 sma inner doors (MIR55ID option) MIRLP option 5 50 250 2 eft and right side R 230 50 45 MIRL5PE MIR55IDPW Notes Prograabe cooed incubators: ) Exterior dimensions of main cabinet ony, excuding hande and other externa projections See dimensions drawings on website for fu detais 2) MIRL5PE operates between +2 C and +50 C 3) Nomina vaue Notes CO 2 incubators: ) Exterior dimensions of main cabinet ony, excuding hande and other externa projections See dimensions drawings on website for fu detais 2) ±0.25ºC; ambient temp 23ºC 25ºC, setting 37ºC, CO 2 5%, O 2 5% (Mutigas), no oad 3) Nomina vaue 4) MCO70AIC series requires MCO70HBPE, MCO70ELPW, MCOHPPW and SafeCe UV option for H 2 O 2 decontamination 5) MCO70AIC series can ony be fitted with one counications interface * Stacking of MCO70AIC series If stacking two incubators, pease refer to the doube stacking tabe for advise on the required stacking options. MCO70AIC series doube stacking tabe Doube stacking options Upper unit MCO70AIC MCO70AIC MCO70PSPW MCO9AIC(M) MCO70SBPW MCO8AC MCO20AIC MCO70SBPW Lower unit Appearance and specifications are subject to change without notice. 23

Discovery starts with a dream. A dream to know who we are. A dream to better our ives... Behind every great discovery, there s the technoogy that made it a possibe. UK Office 9 The Office Viage North Road, Loughborough Leicestershire LE QJ United Kingdom Te. +44(0)509 265265 Fax. +44(0)509 269770 biomedica.uk@eu.panasonicheathcare.com www.biomedica.panasonic.co.uk Head Office Nijverheidsweg 20 4879 AZ Etten Leur The Netherands Te: +3 (0)76 543 38 33 Fax: +3 (0)76 54 37 32 biomedica.n@eu.panasonicheathcare.com www.biomedica.panasonic.eu France Office 44, avenue de Vavins, BP 44 F7722 Avon Cedex France Te. +33 60799 Fax. +33 607693 biomedica.fr@eu.panasonicheathcare.com Panasonic Heathcare Co., Ltd., Gunma factory is certified for: Quaity management system: ISO900 / Medica devices quaity management system: ISO3485 / Environmenta management system: ISO0 205 Panasonic Biomedica Saes Europe B.V. Pubication Number: 23