Mission 份有限公司 wwwom 先锋科技股份有限公司 www Working with our customers we identify, design and deliver low light detection solutions which solve customer probl

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份有限公司 wwwom 先锋科技股份有限公司 www 份有限公司 wwwom 先锋科技股份有限公司 Solutions for Nuclear Medicine sensl: light detection and measurement

Mission 份有限公司 wwwom 先锋科技股份有限公司 www Working with our customers we identify, design and deliver low light detection solutions which solve customer problems and add value. We aim to be the partner of choice because of our flexibility, capabilities and the desire to meet our customer needs. 份有限公司 wwwom 先锋科技股份有限公司 August - 2009 www.sensl.com 2

Motivation Solid State Vacuum Tube LightBulb (Edison) 份有限公司 wwwom 先锋科技股份有限公司 www...is to provide a lower cost and technology enabling solid-state alternative to the vacuum tube based photomultiplier 份有限公司 wwwom 先锋科技股份有限公司 tube (PMT)... 1875 1900 1925 CRT (Ferdinand Braun) Vacuum Tube Diode (Fleming) Photomultiplier Tube (RCA) Silicon Transistor (Texas Inst.) Plasma TV (Bitzer/Gene Slottow) LED (Holonyak) ENIAC (17,468 Tubes) CMOS chip (174,569 transistors) sensl SPMArray 1950 1975 2000 August - 2009 www.sensl.com 3

Introduction Silicon PhotoMultiplier (SPM) detectors are an exciting detector choice for nuclear medicine (PET & SPECT) of various modalities 份有限公司 wwwom 先锋科技股份有限公司 www 份有限公司 wwwom 先锋科技股份有限公司 These high gain, low voltage, silicon detectors are ideally suited for coupling with scintillation crystals such as LYSO to form a scalable architecture for nuclear medical imaging sensl offer a full range of detectors and expertise to assist our customers in the adoption of SPM technology August - 2009 www.sensl.com 4

SPM concept 份有限公司 wwwom 先锋科技股份有限公司 www Geiger mode Detector A photon counting diode detector fabricated in silicon forms the basis for all sensl products 份有限公司 wwwom 先锋科技股份有限公司 Silicon Photomultiplier (SPM) By fabricating large arrays of photon counting detectors, sensl create a high gain detector to replace the PMT August - 2009 www.sensl.com 5

Where does an SPM come from? 份有限公司 wwwom 先锋科技股份有限公司 www 份有限公司 wwwom 先锋科技股份有限公司 sensl SPM detectors are bulk manufactured in a ISO9000 controlled semiconductor foundry sensl test and package to produce the best SPM products on the market August - 2009 www.sensl.com 6

Why use SPM detectors? 份有限公司 wwwom 先锋科技股份有限公司 www Compared to PMT detectors 份有限公司 wwwom 先锋科技股份有限公司 Very small form factor Rugged and immune to magnetic fields and vibrations User safe voltages Similar high gain Compared to PIN and APD detectors Much higher gain simpler system design Much lower system cost and power Less sensitive to bias and temperature change Can operate at higher temperatures August - 2009 www.sensl.com 7

SPM for nuclear medicine 份有限公司 wwwom 先锋科技股份有限公司 www SPM detectors detect light from scintillating crystals 份有限公司 wwwom 先锋科技股份有限公司 SPM detector in robust ceramic package Crystal coupled directly to a sensl SPM Combining a SPM detector with LYSO crystals for example, allows the 511keV photon from a PET scan to be detected August - 2009 www.sensl.com 8

PET/MRI Nuclear Medicine Modalities sensl provides the fullest range of MRI compatible detectors and electronics designed for operation in high Tesla MRI Full body PET sensl provides low cost 4-side scalable technology Preclinical PET sensl provides flexible pixel and packaging options Organ specific PET sensl provides novel packaging and custom configurations In-vivo PET / Gamma Cameras sensl is the leading supplier of low operating voltage SPM SPECT sensl provides miniature detectors ideal for compact SPECT 份有限公司 wwwom 先锋科技股份有限公司 www 份有限公司 wwwom 先锋科技股份有限公司 August - 2009 www.sensl.com 9

Building a PET module 份有限公司 wwwom 先锋科技股份有限公司 www 1) Arrays of SPM detectors can be mounted to cover a large field of view 份有限公司 wwwom 先锋科技股份有限公司 2) Coupling of the scintillation crystals to the SPM detector yields a compact detection head August - 2009 www.sensl.com 10

PET full ring 份有限公司 wwwom 先锋科技股份有限公司 www 份有限公司 wwwom 先锋科技股份有限公司 sensl's SPM provides: energy resolution spatial resolution timing high gain magnetic field operation required by PET systems August - 2009 www.sensl.com 11

Readout electronics 份有限公司 wwwom 先锋科技股份有限公司 www 份有限公司 wwwom 先锋科技股份有限公司 For researchers sensl are a founding member of the openpet readout architecture group http://openpet.lbl.gov/ For OEMs sensl work directly with OEMs to provide a scalable fully digital system August - 2009 www.sensl.com 12

Energy resolution 份有限公司 wwwom 先锋科技股份有限公司 www 份有限公司 wwwom 先锋科技股份有限公司 sensl SPM are ideal for detection of common high energy sources and particles August - 2009 www.sensl.com 13

Temperature stability 份有限公司 wwwom 先锋科技股份有限公司 www 份有限公司 wwwom 先锋科技股份有限公司 Operation can be stabilized over a wide temperature range August - 2009 www.sensl.com 14

Linearity 份有限公司 wwwom 先锋科技股份有限公司 www 份有限公司 wwwom 先锋科技股份有限公司 Linearity up to 3MeV August - 2009 www.sensl.com 15

Timing resolution 份有限公司 wwwom 先锋科技股份有限公司 www 份有限公司 wwwom 先锋科技股份有限公司 Coincidence resolving time (CRT) suitable for standard nuclear medical systems with sub nanosecond timing resolution August - 2009 www.sensl.com 16

Products for nuclear medicine 份有限公司 wwwom 先锋科技股份有限公司 www Detector Products Evaluation Kits SPMMicro 1mm, 3mm & 6mm 份有限公司 wwwom 先锋科技股份有限公司 SPMArray2 (glass) 3-side scalable 16 element detector SPMArray Eval Board SPMArray4 (ceramic) 4-side scalable 16 element detector ScintPack1 August - 2009 www.sensl.com 17

SPMMicro 份有限公司 wwwom 先锋科技股份有限公司 www Features 份有限公司 wwwom 先锋科技股份有限公司 1mm, 3mm, 6mm diameter 35um, 50um, 100um microcell size Low voltage operation (~30V) Unmatched breakdown voltage uniformity Ceramic package with epoxy coating Optional amplifier board with power supply for system test and prototyping Designed for miniaturized systems and for initial testing of SPM technology at the pixel level August - 2009 www.sensl.com 18

SPMArray2 (glass) Features 3-side scalable design 16 channels Ideal for depth of interaction subject side mounting possible MRI compatible 份有限公司 wwwom 先锋科技股份有限公司 www 份有限公司 wwwom 先锋科技股份有限公司 Cable lengths up to 3m 16 channel preamplifier option evaluation board option Ideal for depth of interaction and space critical applications August - 2009 www.sensl.com 19

SPMArray4 (ceramic) Features 份有限公司 wwwom 先锋科技股份有限公司 www 份有限公司 wwwom 先锋科技股份有限公司 4-side scalable design 16 channels single power supply Ceramic package with epoxy coating Designed for simultaneous MRI compatibility to 3 Tesla 16 channel preamplifier option Evaluation board option Designed for large area scalable applications August - 2009 www.sensl.com 20

ScintPack1 份有限公司 wwwom 先锋科技股份有限公司 www 份有限公司 wwwom 先锋科技股份有限公司 Features 3mm and 6mm SPM detectors LYSO, BGO and CsI(Tl) crystal samples Mounting grease in syringe Amplifier board with power supply Instruction manual Allows the user to get up to speed and rapid prototype with sensl SPM technology August - 2009 www.sensl.com 21

Conclusions sensl provide the most comprehensive SPM portfolio on the market 份有限公司 wwwom 先锋科技股份有限公司 www sensl's SPM detectors are ideal for OEM and research nuclear medicine systems where users require performance, flexibility and manufacturability 份有限公司 wwwom 先锋科技股份有限公司 Benefits to our customers: uniformity, low volume system cost, high performance, robustness, reliability, low operating voltages, high volume and scalable technology August - 2009 www.sensl.com 22