get mass. without massive work. [ 3100 MASS DETECTOR ]

Transcription

1 get mass. without massive work. [ 3100 MASS DETECTOR ]

2 Stringent regulations, increasing demands for higher throughput, and the necessity to generate the best possible data all add to the burden of today s analytical laboratories. The Waters 3100 Mass Detector provides your laboratory with a fast, simple, and flexible analytical platform that enables you to rapidly screen and confirm molecular weights, effortlessly track chromatographic peaks, purify with maximum recovery, and quantitate with superior sensitivity and selectivity. Designed to enhance your HPLC capabilities, its rapid scan speeds and ultra-fast polarity switching allows you to generate higher quality information about your sample in less time, whatever your application. The 3100 Mass Detector simply puts advanced knowledge of your compound at your fingertips and delivers new levels of productivity to your laboratory.

3 The 3100 Mass Detector provides you with all the advantages of MS detection. This versatile and easy-to-use single quadrupole MS detector allows for chemists with all levels of experience to generate superior quality results.

4 Easily use MS detection without worrying about MS setup The 3100 Mass Detector brings straightforward mass spectrometry to your laboratory benchtop, in an instrument that s simple to operate. This detector enables you to increase productivity through high quality results in less time and obtain advanced knowledge of your compound with an easy-to-use platform. An MS instrument that s ready when you are The 3100 Mass Detector uses IntelliStart Technology to automate start-up tasks, compound optimization, MS method development, and system performance checks. Support services available through Connections INSIGHT ISDP are proactive, minimizing the time needed to resolve any problems that may occur. IntelliStart Technology IntelliStart Technology comprises both hardware and software advancements that enable even your most inexperienced chemist to operate the instrument quickly and produce high-quality data with complete confidence. With the functionality of IntelliStart, you can seamlessly set up and operate the MS detector: n System monitoring Continuously monitors instrument and system parameters in the background, ensuring your system is ready to run. n Resolution and calibration setup Automatically performs mass calibration and sets MS resolution so you don t have to. n Sample tuning and MS method development Achieves the very best detection limits by automatically optimizing API source conditions for specific analytical conditions and generating compound-specific Single Ion Recording (SIR) methods. Reliability and versatility For excellent sensitivity and selectivity, the 3100 Mass Detector features the patented, dual-orthogonal ZSpray Atmospheric Pressure Ionization (API) Source interface, which provides the industry standard for salt tolerance and robustness to withstand all types of complex matrices. Tried and tested over several generations of Waters mass spectrometers, its dual-orthogonal ion pathway ensures that fewer non-ionic species enter the instrument, delivering excellent spectral quality while keeping the ion optics clean. This allows you to spend more time analyzing samples, and less time cleaning your system. With the latest-generation ZSpray Ion Source supplied on the 3100 Mass Detector, removing and cleaning the sample cone when necessary is an easy job. With the vacuum isolation valve and tool free cone removal and replacement features, you can be acquiring data after cleaning in almost no time at all. Able to support ESI, IonSABRE APCI, ESCi multi-mode, APPI, and dual APPI/APCI ionization modes, and combined with the latest generation ZSpray Ion Source, the 3100 Mass Detector is one of the most robust and flexible single quadrupole mass detectors on the market. n LC/MS system check Checks the performance of your LC/MS system to provide analytical assurance. Connections INSIGHT ISDP Use of the proactive Connections INSIGHT Intelligent Service Delivery Platform (ISDP) dramatically enhances your service and support experience and provides your laboratory with a system that enjoys maximum system uptime, increased laboratory productivity, and lower support operating costs.

5 Flexibility to meet all your analytical challenges The 3100 Mass Detector brings unparalleled sensitivity, selectivity, and throughput in a compliant-ready platform for a diverse range of applications. Cleaning validation Streamline your workflow for cleaning validation. Now you can use a single HPLC/MS method to detect multiple active pharmaceutical ingredients while maintaining good sensitivity and resolution. Using the 3100 Mass Detector with optional OpenLynx Open Access Application Manager software enables you to create a limited number of easily-selectable methods to cover all of your formulation analyses. This user-friendly system configuration increases laboratory productivity by allowing even novice chemists to simply walk up to the instrument, choose a method that matches their sample analysis needs, and retrieve results with minimal training. Impurity profiling HPLC/MS with ESCi for polarity and ion-mode switching enables your laboratory to achieve accurate and precise detection and quantification of sample impurities in just one analytical run. The 3100 Mass Detector s high scan rates produce data that allows you to confirm the identity of your compounds without the need to outsource your analytical work to another facility saving time and money in high-volume laboratory environments. Peak tracking With any method development activity, your chromatographic goal is to successfully separate key compounds as quickly as possible while maintaining data quality. With the 3100 Mass Detector, you gain an easy way to monitor peak retention while HPLC/MS conditions are being optimized. Peak tracking using mass removes the need to individually inject your standard compounds. This technique significantly increases the throughput of your method development workflow and overall productivity. Using the Waters 3100 Mass Detector allows you to effortlessly track your peaks while optimizing method conditions, which enables you to avoid running injections of individual standard compounds. This approach can significantly shorten the time it takes to develop robust and reliable methods, streamlining your workflows and enhancing your laboratory efficiency A B?????? C D Figure 1. Chromatogram A is a 250nm UV chromatogram of a six component mixture, run at ph3 on a Waters Sunfire C18 column, chromatogram B is composed of overlaid extracted mass chromatograms of the individual component masses from the same run. Chromatogram C is a 250nm UV chromatogram of the same six component mixture run at ph10 on a Waters XBridge C18 column, chromatogram D is composed of overlaid extracted mass chromatograms of the individual component masses from the same run.

6 Streamlining your purification workflow The Waters AutoPurification System,* incorporating the 3100 Mass Detector, is designed for everyday mass-directed purification applications. Easy column switching The system enables you to switch up to five columns (three analytical and two preparative) with a single command. The system s fluidics layout, enhanced software features, and hardware capabilities, combined with Waters proprietary Optimum Bed Density (OBD ) Preparative Column Technology,** deliver simplified operation. Streamlining your purification workflow is simple Many components of a mixture respond similarly in a UV detector and provide several fractions. The 3100 Mass Detector reduces the number of fractions collected to improve the overall efficiency of your purification process. When used together, mass spectrometry and PDA detection ensure maximum overall system efficiency. A: TAC Open access purification OpenLynx Open Access Software enables novice and experienced analysts to utilize the full potential of the purification system with minimal training. Chemists can literally walk up to the instrument, submit samples through an easy-to-follow wizard or a single-page login, walk away, and retrieve results online at their convenience. Results can be automatically ed or printed in a customized format, or saved as a PDF, and data can be transferred to remote computers. System management is just as simple. Online, an administrator remotely defines system users and their privileges for operating instruments across the network. Superior purification By using mass detection to trigger fraction collection, you need only collect your compound of interest. This makes the tasks of fraction analysis, pooling, dry-down, and reconstitution simpler and faster. You benefit from increased productivity in purification activities while collecting maximum yields of your compound(s). B: TIC and represent collected fractions Figure 2. Chromatogram A shows the Total Absorbance Chromatogram (TAC) of a seven component mixture by PDA detection. Triggering by UV detection resulted in seven collected fractions. Chromatogram B shows the MS Total Ion Chromatogram (TIC) of the same seven component mixture. Because fraction collection was automatically triggered only on the mass of interest, just one fraction was collected that contained the compound of interest. * The Waters AutoPurification System is only available on MassLynx Software with the FractionLynx Application Manager. **UK patent #GB Advanced features When combined with other advanced system features such as At-Column Dilution, automated solvent management, solvent monitoring, and remote status monitoring, the AutoPurification System provides a fully-featured and flexible platform to cover all your purification needs, from metabolite and impurity isolation to biomolecule and standard purification.

7 It s accessible. With IntelliStart Technology, you can be certain that your system is ready to run. Combined with an integrated fluidics system, IntelliStart Technology automates and optimizes all instrument setup tasks, eliminating the need for manual re-plumbing, and allowing even novice users to generate exceptional data all of the time. It s robust. No matter how complex (or dirty!) your sample matrix might be, safeguards built into the 3100 Mass Detector s ZSpray dual-orthogonal ionization source make it robust and reliable for daily use. Tool-free access to the source and tool-free removal of the sample cone make it easy to clean within minutes when necessary. It s versatile. The 3100 Mass Detector features Waters most popular MS technology: ESCi multi-mode ionization, offering both ESI and APCI as well as positive and negative switching all in one source. The detector provides a comprehensive set of ionization modes suitable for ionization of a wide range of compound classes with an optional APPI source and multi-mode APPI/APCI source. It s highly compatible. Whether your laboratory operates on MassLynx or Empower 2 software, the 3100 Mass Detector easily integrates with your existing laboratory infrastructure. The detector is also compatible with systems containing other detection technologies, including Tuneable UV (TUV), Photodiode Array (PDA), Evaporative Light Scattering (ELS), and Fluorescence (FLR). It s flexible. The 3100 Mass Detector brings speed and flexibility to your applications, no matter how diverse. Whether you need to streamline method development, get information about synthetic reactions to chemists quicker and easier, or purify milligram to gram amounts of compound, this detector will upgrade your laboratory capabilities to where you need them to be. It s smart. With a remote intelligent support system making sure your instrument is performing at its best, laboratory downtime is minimized and problem resolution is faster with the Connections INSIGHT ISDP. It s compact. And it fits on your bench. At only 34.5 cm (13.6 in.) wide, the 3100 Mass Detector is ideal for space-conscious laboratories.

8 Sales Offices: Austria Australia Belgium and Luxembourg Brazil Canada China Czech Republic Denmark Finland France Germany Hong Kong Hungary India Ireland Italy Japan Korea Mexico The Netherlands Norway Poland Puerto Rico Russia/CIS / Singapore Spain Sweden Switzerland Taiwan UK US Waters Corporation 34 Maple Street Milford, MA U.S.A. T: F: Waters, ESCi, and Connections INSIGHT are registered trademarks of Waters Corporation. The Science of What s Possible, IntelliStart, ZSpray, MassLynx, Empower, IonSABRE, OpenLynx, AutoPurification, OBD, and FractionLynx are trademarks of Waters Corporation. All other trademarks are the property of their respective owners Waters Corporation. Printed in the U.S.A. December EN TK-CP