PRESTO. PrestoCHILL PrestoCHILL

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1 Accessories for easierofoperation The unique protocol Excellent quality with the system The combination of freezing the specimens with and processing/staining the slides with the processor allows high-quality results in less than 0 minutes. Breast Thyroid 0X Eosin staining Lens paper disks for easy mounting Molds to fit every requirement Hematoxylin staining High throughput operations To eliminate the potential formation of ice on the freezing platform, an automatic defrost cycle is provided. It consists of an embedded heater in the freezing platform and a vacuum pump to extract water vapours vapors from the chamber. Vapours Vapors are arecondensed condensed and and collected in a cold-trap placed in the front of the unit for easy handling. A HEPA filter is provided on the exhaust side of the pump. Integrated software can set the defrost cycle to take place during off hours. Afterwards, the cooling cycle automatically restarts at a preset time to ensure the availability for the first case of the day, removing the need to manually monitor the system. -CATEN-00.indd -,- -CATEN-00_MD.indd freezing Processor/Stainer for high-quality frozensimultaneous sections The science of cryoembedding The science of cryoembedding for high-quality for high-quality frozen sections frozen sections No liquid nitrogen, no CO, no isopentane. Reduce processing/staining time tostep. minutes. No operations inside the cryostat chamber during the freezing HEPA cap filter. FLEXIBILITY ENVIRONMENTALLY FRIENDLY Set and modify protocols according to your specific requirements The technologically advanced Stirling cooler uses Helium gas as a refrigerant in a sealed stainless your ownisstaining reagents. steel chamber. No standarduse compressor used, therefore no CFCs (Chlorofluorocarbons). Xylene FULLY DOCUMENTABLE FULL DOCUMENTATION A USB port enables both software update and event log downloads. Enable both updating of sotware and downloading of event logs SPACE SAVING through USB port. Its reduced dimensions occupy minimum space in restricted lab environments. A wide variety of molds with different diameter and depth are available to fullfill every freezing requirement. Since the Immersion of a rack withdiameter up to slides for 0 the seconds Lens paper disks are an excellent support outside is always same they can in preheated ( C) FineFix solution for simultaneous: for freezing small fragments or delicate be rapidly exchanged to fit every situation. specimens making the difficult task specimen simple fixation, dehydration and clearing. FineFixofis a patented (EP B-US 0000) and rapid. Available in sizes (diameters formalin-free solution, ethanol based (0%) ideal for,, 0 mm). Built-in exhaust system. - Stirling cooler freezing module - Anodised aluminium freezing platform - Dimensions: height cm (with cover open cm) - width 0cm - depth cm - Weight: kg - Processor/Stainer for up to slides - Power supply: 0V~ 0 histological applications and molecular studies. Each mold can be separately timed through the built-in control panel. Up to samples can be frozen in parallel or in sequential order in less than minutes. / operations with fully automatic defrost feature Only 0 minutes from room to the operating temperature of -0 C. PRODUCTIVITY At the set temperature, biospecimens frozen simultaneously only 0 seconds. stained, Improve flowcan andbeproductivity. While slidesinare automatically Reduced trimming time at the cryostat state through specimen planarity in the cryoembedding compound. the operator is free to cryoembed and cut new specimens. Easy Operating operation Procedures make everyone an expert Best - Dimensions: h 80 cm/. (with cover open 8, cm/. ) **The Art of Embedding Tissue for Frozen Section. Part I: A System Precision Face Down Cryoembedding of Tissues Using Freezing w 0 cm/. - d for 9cm/. Temperature-Embedding Wells. Stephen R. Peters - The Journal of Histology / Vol., No. / March 00 - Weight: 0Kg - lbs **Paper Cryoembedding Stephen R. Peters - The Journal of Histology / Vol., No. / September 00 - Power supply: 0V~ 0/0Hz or V~ 0Hz (00W) A manual with Best Operating Procedures (BOP) is available with every unit. The QR code in this page is directly connected to video tutorials to make operations even easier.. How to identify frozen specimens. How to freeze breast and fatty tissues. How to simultaneously freeze small specimens. How to freeze long-thin specimens. How to freeze muscle tissues. How to freeze thin specimens on edge. How to freeze multiple thin specimens on edge 8. How to freeze skin for MOHS surgery Operator can easily set protocols to fit 9. How to freeze body fluids his lab requirements. -CAT0EN-00.indd - User friendly intuitive software. Intended for professionals only Lung FLEXIBLE IMPROVED MORPHOLOGY Standardized for all types of tissues, even for the most difficult to cut at the Standardised freezing at -0 C cryostat (such as breast, lymph nodes). Assure high quality, consistent staining results independent from Rapidly change out molds with a range of different sizes and designs. operator skill. MCC an optimised optimized cryoembedding compound Aceticformulation acid rinsing of MCC is a proprietary glycols and resins specifically developed for optimal support during cryotomy of dissected tissues down to -0 C. Being water soluble, MCC doesn t leave residue on the slides, eliminating nonwater specific Source rinsing background staining. Additionally, MCC will not dull microtome knives. The s MILESTONE Srl - Via Fatebenefratelli, / - 00 Sorisole (BG) - Italy Tel: Fax: medical@milestonesrl.com MILESTONE MEDICAL TECHNOLOGIES, INC. Technology Avenue, Suite F, Kalamazoo, MI USA Tel: Toll-free: Fax: info@milestonemed.com Wharfedale Road, Winnersh, Wokingham, Berkshire RG RA Tel: , Fax: enquiries@menarinidiag.co.uk MILESTONE Simultaneous freezing H E L P I N G P A T I E N T S CP80 CATEN-00 /0/ 09:09 0: /0/8 0:0 /0/

2 Need good results? Start with a good preparation The optimal frozen section begins with an evenly and completely frozen tissue block in which the block face that will be sectioned is flat and includes a complete, full faced section of the tissue submitted. The section should be free of ice crystal artifacts, knife lines, and/or tears. The speed and simplicity of s operations revolutionise the rapid freezing process, keeping the microscopic appearance of tissues true-to-life.. The first step towards high-quality frozen sections Simple. Intuitive operations Cryoembedding of delicate tissues - small fragments/mohs surgery During the practice of frozen section pathology, pathologists often encounter the task of embedding tissues that are extremely delicate because of the nature of their consistence and structure. This is a situation that occurs daily during Mohs surgery, in which the technologist handles delicate slivers of skin with the goal of accurately embedding these tissues to completely visualise the epidermis and its margin. The paper embedding technique offers a safe and rapid solution to these problems. ** Place a drop of the cryo-embedding compound on the tip of the spatula. Orient the specimen. Transfer the specimen to the bottom of the mold. The science of paper cryoembedding removable aluminum molds with a diameter of -0 mm. (Other sizes and shapes are available) Heat extractors Chuck freezing area - Benchtop cryoembedding station Time to redefine frozen sections Touch screen terminal (. ) Reduce freezing time to 0 seconds. Eliminate freezing artifacts through ultrafast freezing, preventing the formation of ice crystals. Cut fatty tissues like breast or lymph nodes without any sort of difficulty and without the distortion of delicate honeycomb structures. USB port for full documentation Cool trap for the defrost step Add the cryo-embedding compound to fill the mold. Place the chuck into the mold. Add the extractor and close the cover. Wet both sides of a small section of lens paper with the cryo-embedding compound. Position the specimen on the lens paper. Check its orientation. Gently slide the specimen, paper side down, into the mold. Add the cryo-embedding compound, the chuck and the heat extractor. After 0 seconds, the specimen is ready for section cutting. The lens paper is eliminated during the initial trimming of the block. The final result. Obtain perfectly flat plane surfaces to reduce trimming time and to cut easily while using the patented* face down embedding technique. Eliminate the compression of artifacts caused by extremely ultra low temperatures. Eliminate the retraction of tissues; for example, Glomeruli from Bowman s capsule, and vacuolation spaces around nucleated brain cells, related to formalin fixed, paraffin-embedded (FFPE) sections. This is how cryoembedding should be Freezing time 0 -CATEN-00.indd CATEN-00_MD.indd NO FREEZING ARTIFACTS 0 SECOND FREEZING TIME AN ALL-DRY SYSTEM FULL DOWNLOADABLE DOCUMENTATION NO LIQUID NITROGEN NO CO - NO ISOPENTANE 8 Start the timer. After 0 seconds A frozen block with a perfectly flat plane surface is ready for cutting. What sets us apart? Cryoembedding on edge THE UNIQUE COMBINATION OF THE PATENTED* FACE-DOWN EMBEDDING TECHNIQUE, TOGETHER WITH A STATE-OF-THE-ART, RAPID STIRLING COOLING DEVICE AT -0 C. With the help of a strip of cellulose it is possible to freeze the specimen on edge with the standard freezing procedure as paper disk cryoembedding. US PATENT,,9 B * /0/ 0:0 0: /0/8

3 Need good results? Start with a good preparation The optimal frozen section begins with an evenly and completely frozen tissue block in which the block face that will be sectioned is flat and includes a complete, full faced section of the tissue submitted. The section should be free of ice crystal artifacts, knife lines, and/or tears. The speed and simplicity of s operations revolutionise the rapid freezing process, keeping the microscopic appearance of tissues true-to-life.. The first step towards high-quality frozen sections Simple. Intuitive operations Cryoembedding of delicate tissues - small fragments/mohs surgery During the practice of frozen section pathology, pathologists often encounter the task of embedding tissues that are extremely delicate because of the nature of their consistence and structure. This is a situation that occurs daily during Mohs surgery, in which the technologist handles delicate slivers of skin with the goal of accurately embedding these tissues to completely visualise the epidermis and its margin. The paper embedding technique offers a safe and rapid solution to these problems. ** Place a drop of the cryo-embedding compound on the tip of the spatula. Orient the specimen. Transfer the specimen to the bottom of the mold. The science of paper cryoembedding removable aluminum molds with a diameter of -0 mm. (Other sizes and shapes are available) Heat extractors Chuck freezing area - Benchtop cryoembedding station Time to redefine frozen sections Touch screen terminal (. ) Reduce freezing time to 0 seconds. Eliminate freezing artifacts through ultrafast freezing, preventing the formation of ice crystals. Cut fatty tissues like breast or lymph nodes without any sort of difficulty and without the distortion of delicate honeycomb structures. USB port for full documentation Cool trap for the defrost step Add the cryo-embedding compound to fill the mold. Place the chuck into the mold. Add the extractor and close the cover. Wet both sides of a small section of lens paper with the cryo-embedding compound. Position the specimen on the lens paper. Check its orientation. Gently slide the specimen, paper side down, into the mold. Add the cryo-embedding compound, the chuck and the heat extractor. After 0 seconds, the specimen is ready for section cutting. The lens paper is eliminated during the initial trimming of the block. The final result. Obtain perfectly flat plane surfaces to reduce trimming time and to cut easily while using the patented* face down embedding technique. Eliminate the compression of artifacts caused by extremely ultra low temperatures. Eliminate the retraction of tissues; for example, Glomeruli from Bowman s capsule, and vacuolation spaces around nucleated brain cells, related to formalin fixed, paraffin-embedded (FFPE) sections. This is how cryoembedding should be Freezing time 0 -CATEN-00.indd CATEN-00_MD.indd NO FREEZING ARTIFACTS 0 SECOND FREEZING TIME AN ALL-DRY SYSTEM FULL DOWNLOADABLE DOCUMENTATION NO LIQUID NITROGEN NO CO - NO ISOPENTANE 8 Start the timer. After 0 seconds A frozen block with a perfectly flat plane surface is ready for cutting. What sets us apart? Cryoembedding on edge THE UNIQUE COMBINATION OF THE PATENTED* FACE-DOWN EMBEDDING TECHNIQUE, TOGETHER WITH A STATE-OF-THE-ART, RAPID STIRLING COOLING DEVICE AT -0 C. With the help of a strip of cellulose it is possible to freeze the specimen on edge with the standard freezing procedure as paper disk cryoembedding. US PATENT,,9 B * /0/ 0:0 0: /0/8

4 Need good results? Start with a good preparation The optimal frozen section begins with an evenly and completely frozen tissue block in which the block face that will be sectioned is flat and includes a complete, full faced section of the tissue submitted. The section should be free of ice crystal artifacts, knife lines, and/or tears. The speed and simplicity of s operations revolutionise the rapid freezing process, keeping the microscopic appearance of tissues true-to-life.. The first step towards high-quality frozen sections Simple. Intuitive operations Cryoembedding of delicate tissues - small fragments/mohs surgery During the practice of frozen section pathology, pathologists often encounter the task of embedding tissues that are extremely delicate because of the nature of their consistence and structure. This is a situation that occurs daily during Mohs surgery, in which the technologist handles delicate slivers of skin with the goal of accurately embedding these tissues to completely visualise the epidermis and its margin. The paper embedding technique offers a safe and rapid solution to these problems. ** Place a drop of the cryo-embedding compound on the tip of the spatula. Orient the specimen. Transfer the specimen to the bottom of the mold. The science of paper cryoembedding removable aluminum molds with a diameter of -0 mm. (Other sizes and shapes are available) Heat extractors Chuck freezing area - Benchtop cryoembedding station Time to redefine frozen sections Touch screen terminal (. ) Reduce freezing time to 0 seconds. Eliminate freezing artifacts through ultrafast freezing, preventing the formation of ice crystals. Cut fatty tissues like breast or lymph nodes without any sort of difficulty and without the distortion of delicate honeycomb structures. USB port for full documentation Cool trap for the defrost step Add the cryo-embedding compound to fill the mold. Place the chuck into the mold. Add the extractor and close the cover. Wet both sides of a small section of lens paper with the cryo-embedding compound. Position the specimen on the lens paper. Check its orientation. Gently slide the specimen, paper side down, into the mold. Add the cryo-embedding compound, the chuck and the heat extractor. After 0 seconds, the specimen is ready for section cutting. The lens paper is eliminated during the initial trimming of the block. The final result. Obtain perfectly flat plane surfaces to reduce trimming time and to cut easily while using the patented* face down embedding technique. Eliminate the compression of artifacts caused by extremely ultra low temperatures. Eliminate the retraction of tissues; for example, Glomeruli from Bowman s capsule, and vacuolation spaces around nucleated brain cells, related to formalin fixed, paraffin-embedded (FFPE) sections. This is how cryoembedding should be Freezing time 0 -CATEN-00.indd CATEN-00_MD.indd NO FREEZING ARTIFACTS 0 SECOND FREEZING TIME AN ALL-DRY SYSTEM FULL DOWNLOADABLE DOCUMENTATION NO LIQUID NITROGEN NO CO - NO ISOPENTANE 8 Start the timer. After 0 seconds A frozen block with a perfectly flat plane surface is ready for cutting. What sets us apart? Cryoembedding on edge THE UNIQUE COMBINATION OF THE PATENTED* FACE-DOWN EMBEDDING TECHNIQUE, TOGETHER WITH A STATE-OF-THE-ART, RAPID STIRLING COOLING DEVICE AT -0 C. With the help of a strip of cellulose it is possible to freeze the specimen on edge with the standard freezing procedure as paper disk cryoembedding. US PATENT,,9 B * /0/ 0:0 0: /0/8

5 Need good results? Start with a good preparation The optimal frozen section begins with an evenly and completely frozen tissue block in which the block face that will be sectioned is flat and includes a complete, full faced section of the tissue submitted. The section should be free of ice crystal artifacts, knife lines, and/or tears. The speed and simplicity of s operations revolutionise the rapid freezing process, keeping the microscopic appearance of tissues true-to-life.. The first step towards high-quality frozen sections Simple. Intuitive operations Cryoembedding of delicate tissues - small fragments/mohs surgery During the practice of frozen section pathology, pathologists often encounter the task of embedding tissues that are extremely delicate because of the nature of their consistence and structure. This is a situation that occurs daily during Mohs surgery, in which the technologist handles delicate slivers of skin with the goal of accurately embedding these tissues to completely visualise the epidermis and its margin. The paper embedding technique offers a safe and rapid solution to these problems. ** Place a drop of the cryo-embedding compound on the tip of the spatula. Orient the specimen. Transfer the specimen to the bottom of the mold. The science of paper cryoembedding removable aluminum molds with a diameter of -0 mm. (Other sizes and shapes are available) Heat extractors Chuck freezing area - Benchtop cryoembedding station Time to redefine frozen sections Touch screen terminal (. ) Reduce freezing time to 0 seconds. Eliminate freezing artifacts through ultrafast freezing, preventing the formation of ice crystals. Cut fatty tissues like breast or lymph nodes without any sort of difficulty and without the distortion of delicate honeycomb structures. USB port for full documentation Cool trap for the defrost step Add the cryo-embedding compound to fill the mold. Place the chuck into the mold. Add the extractor and close the cover. Wet both sides of a small section of lens paper with the cryo-embedding compound. Position the specimen on the lens paper. Check its orientation. Gently slide the specimen, paper side down, into the mold. Add the cryo-embedding compound, the chuck and the heat extractor. After 0 seconds, the specimen is ready for section cutting. The lens paper is eliminated during the initial trimming of the block. The final result. Obtain perfectly flat plane surfaces to reduce trimming time and to cut easily while using the patented* face down embedding technique. Eliminate the compression of artifacts caused by extremely ultra low temperatures. Eliminate the retraction of tissues; for example, Glomeruli from Bowman s capsule, and vacuolation spaces around nucleated brain cells, related to formalin fixed, paraffin-embedded (FFPE) sections. This is how cryoembedding should be Freezing time 0 -CATEN-00.indd CATEN-00_MD.indd NO FREEZING ARTIFACTS 0 SECOND FREEZING TIME AN ALL-DRY SYSTEM FULL DOWNLOADABLE DOCUMENTATION NO LIQUID NITROGEN NO CO - NO ISOPENTANE 8 Start the timer. After 0 seconds A frozen block with a perfectly flat plane surface is ready for cutting. What sets us apart? Cryoembedding on edge THE UNIQUE COMBINATION OF THE PATENTED* FACE-DOWN EMBEDDING TECHNIQUE, TOGETHER WITH A STATE-OF-THE-ART, RAPID STIRLING COOLING DEVICE AT -0 C. With the help of a strip of cellulose it is possible to freeze the specimen on edge with the standard freezing procedure as paper disk cryoembedding. US PATENT,,9 B * /0/ 0:0 0: /0/8

6 Accessories for easierofoperation The unique protocol Excellent quality with the system The combination of freezing the specimens with and processing/staining the slides with the processor allows high-quality results in less than 0 minutes. Breast Thyroid 0X Eosin staining Lens paper disks for easy mounting Molds to fit every requirement Hematoxylin staining High throughput operations To eliminate the potential formation of ice on the freezing platform, an automatic defrost cycle is provided. It consists of an embedded heater in the freezing platform and a vacuum pump to extract water vapours vapors from the chamber. Vapours Vapors are arecondensed condensed and and collected in a cold-trap placed in the front of the unit for easy handling. A HEPA filter is provided on the exhaust side of the pump. Integrated software can set the defrost cycle to take place during off hours. Afterwards, the cooling cycle automatically restarts at a preset time to ensure the availability for the first case of the day, removing the need to manually monitor the system. -CATEN-00.indd -,- -CATEN-00_MD.indd freezing Processor/Stainer for high-quality frozensimultaneous sections The science of cryoembedding The science of cryoembedding for high-quality for high-quality frozen sections frozen sections No liquid nitrogen, no CO, no isopentane. Reduce processing/staining time tostep. minutes. No operations inside the cryostat chamber during the freezing HEPA cap filter. FLEXIBILITY ENVIRONMENTALLY FRIENDLY Set and modify protocols according to your specific requirements The technologically advanced Stirling cooler uses Helium gas as a refrigerant in a sealed stainless your ownisstaining reagents. steel chamber. No standarduse compressor used, therefore no CFCs (Chlorofluorocarbons). Xylene FULLY DOCUMENTABLE FULL DOCUMENTATION A USB port enables both software update and event log downloads. Enable both updating of sotware and downloading of event logs SPACE SAVING through USB port. Its reduced dimensions occupy minimum space in restricted lab environments. A wide variety of molds with different diameter and depth are available to fullfill every freezing requirement. Since the Immersion of a rack withdiameter up to slides for 0 the seconds Lens paper disks are an excellent support outside is always same they can in preheated ( C) FineFix solution for simultaneous: for freezing small fragments or delicate be rapidly exchanged to fit every situation. specimens making the difficult task specimen simple fixation, dehydration and clearing. FineFixofis a patented (EP B-US 0000) and rapid. Available in sizes (diameters formalin-free solution, ethanol based (0%) ideal for,, 0 mm). Built-in exhaust system. - Stirling cooler freezing module - Anodised aluminium freezing platform - Dimensions: height cm (with cover open cm) - width 0cm - depth cm - Weight: kg - Processor/Stainer for up to slides - Power supply: 0V~ 0 histological applications and molecular studies. Each mold can be separately timed through the built-in control panel. Up to samples can be frozen in parallel or in sequential order in less than minutes. / operations with fully automatic defrost feature Only 0 minutes from room to the operating temperature of -0 C. PRODUCTIVITY At the set temperature, biospecimens frozen simultaneously only 0 seconds. stained, Improve flowcan andbeproductivity. While slidesinare automatically Reduced trimming time at the cryostat state through specimen planarity in the cryoembedding compound. the operator is free to cryoembed and cut new specimens. Easy Operating operation Procedures make everyone an expert Best - Dimensions: h 80 cm/. (with cover open 8, cm/. ) **The Art of Embedding Tissue for Frozen Section. Part I: A System Precision Face Down Cryoembedding of Tissues Using Freezing w 0 cm/. - d for 9cm/. Temperature-Embedding Wells. Stephen R. Peters - The Journal of Histology / Vol., No. / March 00 - Weight: 0Kg - lbs **Paper Cryoembedding Stephen R. Peters - The Journal of Histology / Vol., No. / September 00 - Power supply: 0V~ 0/0Hz or V~ 0Hz (00W) A manual with Best Operating Procedures (BOP) is available with every unit. The QR code in this page is directly connected to video tutorials to make operations even easier.. How to identify frozen specimens. How to freeze breast and fatty tissues. How to simultaneously freeze small specimens. How to freeze long-thin specimens. How to freeze muscle tissues. How to freeze thin specimens on edge. How to freeze multiple thin specimens on edge 8. How to freeze skin for MOHS surgery Operator can easily set protocols to fit 9. How to freeze body fluids his lab requirements. -CAT0EN-00.indd - User friendly intuitive software. Intended for professionals only Lung FLEXIBLE IMPROVED MORPHOLOGY Standardized for all types of tissues, even for the most difficult to cut at the Standardised freezing at -0 C cryostat (such as breast, lymph nodes). Assure high quality, consistent staining results independent from Rapidly change out molds with a range of different sizes and designs. operator skill. MCC an optimised optimized cryoembedding compound Aceticformulation acid rinsing of MCC is a proprietary glycols and resins specifically developed for optimal support during cryotomy of dissected tissues down to -0 C. Being water soluble, MCC doesn t leave residue on the slides, eliminating nonwater specific Source rinsing background staining. Additionally, MCC will not dull microtome knives. The s MILESTONE Srl - Via Fatebenefratelli, / - 00 Sorisole (BG) - Italy Tel: Fax: medical@milestonesrl.com MILESTONE MEDICAL TECHNOLOGIES, INC. Technology Avenue, Suite F, Kalamazoo, MI USA Tel: Toll-free: Fax: info@milestonemed.com Wharfedale Road, Winnersh, Wokingham, Berkshire RG RA Tel: , Fax: enquiries@menarinidiag.co.uk MILESTONE Simultaneous freezing H E L P I N G P A T I E N T S CP80 CATEN-00 /0/ 09:09 0: /0/8 0:0 /0/

7 Accessories for easierofoperation The unique protocol Excellent quality with the system The combination of freezing the specimens with and processing/staining the slides with the processor allows high-quality results in less than 0 minutes. Breast Thyroid 0X Eosin staining Lens paper disks for easy mounting Molds to fit every requirement Hematoxylin staining High throughput operations To eliminate the potential formation of ice on the freezing platform, an automatic defrost cycle is provided. It consists of an embedded heater in the freezing platform and a vacuum pump to extract water vapours vapors from the chamber. Vapours Vapors are arecondensed condensed and and collected in a cold-trap placed in the front of the unit for easy handling. A HEPA filter is provided on the exhaust side of the pump. Integrated software can set the defrost cycle to take place during off hours. Afterwards, the cooling cycle automatically restarts at a preset time to ensure the availability for the first case of the day, removing the need to manually monitor the system. -CATEN-00.indd -,- -CATEN-00_MD.indd freezing Processor/Stainer for high-quality frozensimultaneous sections The science of cryoembedding The science of cryoembedding for high-quality for high-quality frozen sections frozen sections No liquid nitrogen, no CO, no isopentane. Reduce processing/staining time tostep. minutes. No operations inside the cryostat chamber during the freezing HEPA cap filter. FLEXIBILITY ENVIRONMENTALLY FRIENDLY Set and modify protocols according to your specific requirements The technologically advanced Stirling cooler uses Helium gas as a refrigerant in a sealed stainless your ownisstaining reagents. steel chamber. No standarduse compressor used, therefore no CFCs (Chlorofluorocarbons). Xylene FULLY DOCUMENTABLE FULL DOCUMENTATION A USB port enables both software update and event log downloads. Enable both updating of sotware and downloading of event logs SPACE SAVING through USB port. Its reduced dimensions occupy minimum space in restricted lab environments. A wide variety of molds with different diameter and depth are available to fullfill every freezing requirement. Since the Immersion of a rack withdiameter up to slides for 0 the seconds Lens paper disks are an excellent support outside is always same they can in preheated ( C) FineFix solution for simultaneous: for freezing small fragments or delicate be rapidly exchanged to fit every situation. specimens making the difficult task specimen simple fixation, dehydration and clearing. FineFixofis a patented (EP B-US 0000) and rapid. Available in sizes (diameters formalin-free solution, ethanol based (0%) ideal for,, 0 mm). Built-in exhaust system. - Stirling cooler freezing module - Anodised aluminium freezing platform - Dimensions: height cm (with cover open cm) - width 0cm - depth cm - Weight: kg - Processor/Stainer for up to slides - Power supply: 0V~ 0 histological applications and molecular studies. Each mold can be separately timed through the built-in control panel. Up to samples can be frozen in parallel or in sequential order in less than minutes. / operations with fully automatic defrost feature Only 0 minutes from room to the operating temperature of -0 C. PRODUCTIVITY At the set temperature, biospecimens frozen simultaneously only 0 seconds. stained, Improve flowcan andbeproductivity. While slidesinare automatically Reduced trimming time at the cryostat state through specimen planarity in the cryoembedding compound. the operator is free to cryoembed and cut new specimens. Easy Operating operation Procedures make everyone an expert Best - Dimensions: h 80 cm/. (with cover open 8, cm/. ) **The Art of Embedding Tissue for Frozen Section. Part I: A System Precision Face Down Cryoembedding of Tissues Using Freezing w 0 cm/. - d for 9cm/. Temperature-Embedding Wells. Stephen R. Peters - The Journal of Histology / Vol., No. / March 00 - Weight: 0Kg - lbs **Paper Cryoembedding Stephen R. Peters - The Journal of Histology / Vol., No. / September 00 - Power supply: 0V~ 0/0Hz or V~ 0Hz (00W) A manual with Best Operating Procedures (BOP) is available with every unit. The QR code in this page is directly connected to video tutorials to make operations even easier.. How to identify frozen specimens. How to freeze breast and fatty tissues. How to simultaneously freeze small specimens. How to freeze long-thin specimens. How to freeze muscle tissues. How to freeze thin specimens on edge. How to freeze multiple thin specimens on edge 8. How to freeze skin for MOHS surgery Operator can easily set protocols to fit 9. How to freeze body fluids his lab requirements. -CAT0EN-00.indd - User friendly intuitive software. Intended for professionals only Lung FLEXIBLE IMPROVED MORPHOLOGY Standardized for all types of tissues, even for the most difficult to cut at the Standardised freezing at -0 C cryostat (such as breast, lymph nodes). Assure high quality, consistent staining results independent from Rapidly change out molds with a range of different sizes and designs. operator skill. MCC an optimised optimized cryoembedding compound Aceticformulation acid rinsing of MCC is a proprietary glycols and resins specifically developed for optimal support during cryotomy of dissected tissues down to -0 C. Being water soluble, MCC doesn t leave residue on the slides, eliminating nonwater specific Source rinsing background staining. Additionally, MCC will not dull microtome knives. The s MILESTONE Srl - Via Fatebenefratelli, / - 00 Sorisole (BG) - Italy Tel: Fax: medical@milestonesrl.com MILESTONE MEDICAL TECHNOLOGIES, INC. Technology Avenue, Suite F, Kalamazoo, MI USA Tel: Toll-free: Fax: info@milestonemed.com Wharfedale Road, Winnersh, Wokingham, Berkshire RG RA Tel: , Fax: enquiries@menarinidiag.co.uk MILESTONE Simultaneous freezing H E L P I N G P A T I E N T S CP80 CATEN-00 /0/ 09:09 0: /0/8 0:0 /0/

8 Accessories for easierofoperation The unique protocol Excellent quality with the system The combination of freezing the specimens with and processing/staining the slides with the processor allows high-quality results in less than 0 minutes. Breast Thyroid 0X Eosin staining Lens paper disks for easy mounting Molds to fit every requirement Hematoxylin staining High throughput operations To eliminate the potential formation of ice on the freezing platform, an automatic defrost cycle is provided. It consists of an embedded heater in the freezing platform and a vacuum pump to extract water vapours vapors from the chamber. Vapours Vapors are arecondensed condensed and and collected in a cold-trap placed in the front of the unit for easy handling. A HEPA filter is provided on the exhaust side of the pump. Integrated software can set the defrost cycle to take place during off hours. Afterwards, the cooling cycle automatically restarts at a preset time to ensure the availability for the first case of the day, removing the need to manually monitor the system. -CATEN-00.indd -,- -CATEN-00_MD.indd freezing Processor/Stainer for high-quality frozensimultaneous sections The science of cryoembedding The science of cryoembedding for high-quality for high-quality frozen sections frozen sections No liquid nitrogen, no CO, no isopentane. Reduce processing/staining time tostep. minutes. No operations inside the cryostat chamber during the freezing HEPA cap filter. FLEXIBILITY ENVIRONMENTALLY FRIENDLY Set and modify protocols according to your specific requirements The technologically advanced Stirling cooler uses Helium gas as a refrigerant in a sealed stainless your ownisstaining reagents. steel chamber. No standarduse compressor used, therefore no CFCs (Chlorofluorocarbons). Xylene FULLY DOCUMENTABLE FULL DOCUMENTATION A USB port enables both software update and event log downloads. Enable both updating of sotware and downloading of event logs SPACE SAVING through USB port. Its reduced dimensions occupy minimum space in restricted lab environments. A wide variety of molds with different diameter and depth are available to fullfill every freezing requirement. Since the Immersion of a rack withdiameter up to slides for 0 the seconds Lens paper disks are an excellent support outside is always same they can in preheated ( C) FineFix solution for simultaneous: for freezing small fragments or delicate be rapidly exchanged to fit every situation. specimens making the difficult task specimen simple fixation, dehydration and clearing. FineFixofis a patented (EP B-US 0000) and rapid. Available in sizes (diameters formalin-free solution, ethanol based (0%) ideal for,, 0 mm). Built-in exhaust system. - Stirling cooler freezing module - Anodised aluminium freezing platform - Dimensions: height cm (with cover open cm) - width 0cm - depth cm - Weight: kg - Processor/Stainer for up to slides - Power supply: 0V~ 0 histological applications and molecular studies. Each mold can be separately timed through the built-in control panel. Up to samples can be frozen in parallel or in sequential order in less than minutes. / operations with fully automatic defrost feature Only 0 minutes from room to the operating temperature of -0 C. PRODUCTIVITY At the set temperature, biospecimens frozen simultaneously only 0 seconds. stained, Improve flowcan andbeproductivity. While slidesinare automatically Reduced trimming time at the cryostat state through specimen planarity in the cryoembedding compound. the operator is free to cryoembed and cut new specimens. Easy Operating operation Procedures make everyone an expert Best - Dimensions: h 80 cm/. (with cover open 8, cm/. ) **The Art of Embedding Tissue for Frozen Section. Part I: A System Precision Face Down Cryoembedding of Tissues Using Freezing w 0 cm/. - d for 9cm/. Temperature-Embedding Wells. Stephen R. Peters - The Journal of Histology / Vol., No. / March 00 - Weight: 0Kg - lbs **Paper Cryoembedding Stephen R. Peters - The Journal of Histology / Vol., No. / September 00 - Power supply: 0V~ 0/0Hz or V~ 0Hz (00W) A manual with Best Operating Procedures (BOP) is available with every unit. The QR code in this page is directly connected to video tutorials to make operations even easier.. How to identify frozen specimens. How to freeze breast and fatty tissues. How to simultaneously freeze small specimens. How to freeze long-thin specimens. How to freeze muscle tissues. How to freeze thin specimens on edge. How to freeze multiple thin specimens on edge 8. How to freeze skin for MOHS surgery Operator can easily set protocols to fit 9. How to freeze body fluids his lab requirements. -CAT0EN-00.indd - User friendly intuitive software. Intended for professionals only Lung FLEXIBLE IMPROVED MORPHOLOGY Standardized for all types of tissues, even for the most difficult to cut at the Standardised freezing at -0 C cryostat (such as breast, lymph nodes). Assure high quality, consistent staining results independent from Rapidly change out molds with a range of different sizes and designs. operator skill. MCC an optimised optimized cryoembedding compound Aceticformulation acid rinsing of MCC is a proprietary glycols and resins specifically developed for optimal support during cryotomy of dissected tissues down to -0 C. Being water soluble, MCC doesn t leave residue on the slides, eliminating nonwater specific Source rinsing background staining. Additionally, MCC will not dull microtome knives. The s MILESTONE Srl - Via Fatebenefratelli, / - 00 Sorisole (BG) - Italy Tel: Fax: medical@milestonesrl.com MILESTONE MEDICAL TECHNOLOGIES, INC. Technology Avenue, Suite F, Kalamazoo, MI USA Tel: Toll-free: Fax: info@milestonemed.com Wharfedale Road, Winnersh, Wokingham, Berkshire RG RA Tel: , Fax: enquiries@menarinidiag.co.uk MILESTONE Simultaneous freezing H E L P I N G P A T I E N T S CP80 CATEN-00 /0/ 09:09 0: /0/8 0:0 /0/