[ F OL IO IN S IDE HE A DE R ]

Transcription

1 [ F OL IO IN S IDE HE A DE R ] WAT E R S U P L C W I T H O N - L I N E S P E T E C H N O L O G Y Automated o-lie SPE with the performace of UPLC Miimize aalyst itervetio ad reduce sample volumes Performig off-lie SPE ad liquid/liquid extractio ca be UPLC with O-lie SPE Techology allows cleaup, cocetratio, labor itesive ad requires umerous vessel trasfers that ad direct elutio to the aalytical colum, which elimiates SAM P L E P RE PA RAT ION AND ANALYSIS IN MINUT ES ca icrease the likelihood of aalyst error. I additio, certai maual itervetio ad reduces sample volume. Sample vials Waters UPLC with O-lie SPE Techology dramatically streamlies the aalysis of water applicatios ca require large sample volumes ad tedious are loaded directly ito the autosampler for preparatio ad samples by providig aalyte extractio, cleaup, cocetratio, separatio, ad detectio sample preparatio. aalysis o additioal vessel trasfer is required. Oce samples i oe tur-key solutio. Automated sample hadlig, proprietary chromatographic media, ad are set up, aalysts are free to focus o more importat tasks. ultra-sesitive optical ad mass spectrometry detectio have bee combied ito a o-lie SPE/LC/MS/MS solutio that requires oly a fractio of the typical sample volume. O-lie SPE/LC/MS/MS for the detectio of: With the first UPLC-pressure eabled, aalytical scale o-lie SPE system, the time required Edocrie disruptors Fugicides Herbicides Pesticides Accommodate more samples ad ru them i less time. Persoal care products Flexibility Fuctios as a o-lie SPE system ad a stad aloe UPLC system with multiple Pharmaceuticals Soft drik additives Veteriary drug residues for preparatio ad aalysis, oce measured i hours, has bee reduced to miutes. Key beefits for laboratory operatios: Reduce sample preparatio ad aalysis times by over 9 Quality Automated sample processig esures reproducible results by elimiatig maual variability. Followig autosampler loadig, the sample is ijected oto a extractio colum packed with sorbet. Durig the loadig phase, target aalytes are trapped at high flow rates o the SPE sorbet, while uretaied iterfereces are directed to waste. Next, the sample is subjected to a mild wash, followed by elutio oto a high-resolutio aalytical colum for separatio ad aalysis. This cofiguratio allows the SPE extractio cartridges to be operated i parallel. Automated software tools, pre-loaded methods ad four solvet optios allow cleaup of the extractio colum to be easily optimized, miimizig aalyte carryover ad potetial iterfereces. Throughput Sample aalysis ad preparatio times reduced by up to 9. optical ad mass spectrometer detectio optios. Maximize laboratory asset utilizatio. Cost The use of sigificatly smaller sample volumes ca reduce shippig costs from remote locatios. With this o-lie cofiguratio, preparatio ad aalysis ca be reduced from up to 3 hours to as little as 15 miutes a reductio of over 9. other laboratory tasks. O-lie SPE with UPLC/MS/MS O the time required for sample SAMPLE PREP AND ANALYSIS METHOD Productivity Reduces sample processig time. Scietists ca allocate more time to UPLC with O-lie SPE Techology. Off-lie SPE with LC/MS/MS TIME (HOURS) Figure 2. Drikig water sample preparatio ad aalysis times. O-lie SPE with UPLC/MS/MS versus Off-lie SPE with LC/MS/MS. Waters, Xevo, UPLC, ACQUITY, ACQUITY UPLC, ad Oasis are registered trademarks of Waters Corporatio. XBridge, MassLyx, TargetLyx, Quapedia, ItelliStart, ad The Sciece of What s Possible are trademarks of Waters Corporatio. All other trademarks are the property of their respective owers. 21 Waters Corporatio. Prited i the U.S.A. Jauary EN AO-CP Waters Corporatio 34 Maple Street Milford, MA 1757 U.S.A. T: F:

2 [ F OL IO IN S IDE HE A DE R ] WAT E R S U P L C W I T H O N - L I N E S P E T E C H N O L O G Y Automated o-lie SPE with the performace of UPLC Miimize aalyst itervetio ad reduce sample volumes Performig off-lie SPE ad liquid/liquid extractio ca be UPLC with O-lie SPE Techology allows cleaup, cocetratio, labor itesive ad requires umerous vessel trasfers that ad direct elutio to the aalytical colum, which elimiates SAM P L E P RE PA RAT ION AND ANALYSIS IN MINUT ES ca icrease the likelihood of aalyst error. I additio, certai maual itervetio ad reduces sample volume. Sample vials Waters UPLC with O-lie SPE Techology dramatically streamlies the aalysis of water applicatios ca require large sample volumes ad tedious are loaded directly ito the autosampler for preparatio ad samples by providig aalyte extractio, cleaup, cocetratio, separatio, ad detectio sample preparatio. aalysis o additioal vessel trasfer is required. Oce samples i oe tur-key solutio. Automated sample hadlig, proprietary chromatographic media, ad are set up, aalysts are free to focus o more importat tasks. ultra-sesitive optical ad mass spectrometry detectio have bee combied ito a o-lie SPE/LC/MS/MS solutio that requires oly a fractio of the typical sample volume. O-lie SPE/LC/MS/MS for the detectio of: With the first UPLC-pressure eabled, aalytical scale o-lie SPE system, the time required Edocrie disruptors Fugicides Herbicides Pesticides Accommodate more samples ad ru them i less time. Persoal care products Flexibility Fuctios as a o-lie SPE system ad a stad aloe UPLC system with multiple Pharmaceuticals Soft drik awdditives Veteriary drug residues for preparatio ad aalysis, oce measured i hours, has bee reduced to miutes. Key beefits for laboratory operatios: Reduce sample preparatio ad aalysis times by over 9 Quality Automated sample processig esures reproducible results by elimiatig maual variability. Followig autosampler loadig, the sample is ijected oto a extractio colum packed with sorbet. Durig the loadig phase, target aalytes are trapped at high flow rates o the SPE sorbet, while uretaied iterfereces are directed to waste. Next, the sample is subjected to a mild wash, followed by elutio oto a high-resolutio aalytical colum for separatio ad aalysis. This cofiguratio allows the SPE extractio cartridges to be operated i parallel. Automated software tools, pre-loaded methods ad four solvet optios allow cleaup of the extractio colum to be easily optimized, miimizig aalyte carryover ad potetial iterfereces. Throughput Sample aalysis ad preparatio times reduced by up to 9. optical ad mass spectrometer detectio optios. Maximize laboratory asset utilizatio. Cost The use of sigificatly smaller sample volumes ca reduce shippig costs from remote locatios. With this o-lie cofiguratio, preparatio ad aalysis ca be reduced from up to 3 hours to as little as 15 miutes a reductio of over 9. other laboratory tasks. O-lie SPE with UPLC/MS/MS O the time required for sample SAMPLE PREP AND ANALYSIS METHOD Productivity Reduces sample processig time. Scietists ca allocate more time to UPLC with O-lie SPE Techology. Off-lie SPE with LC/MS/MS TIME (HOURS) Figure 2. Drikig water sample preparatio ad aalysis times. O-lie SPE with UPLC/MS/MS versus Off-lie SPE with LC/MS/MS. Waters, Xevo, UPLC, ACQUITY, ACQUITY UPLC, ad Oasis are registered trademarks of Waters Corporatio. XBridge, MassLyx, TargetLyx, Quapedia, ItelliStart, ad The Sciece of What s Possible are trademarks of Waters Corporatio. All other trademarks are the property of their respective owers. 21 Waters Corporatio. Prited i the U.S.A. Jauary EN AO-CP Waters Corporatio 34 Maple Street Milford, MA 1757 U.S.A. T: F:

3 Waters UPLC with O-lie SPE Techology is a completely itegrated solutio. Ultra sesitivity easily meet or e xceed detectio requiremets Excellet reproducibility ad liearity more cofidece i your results Advaced data maagemet Waters provides three distict Each compoet operates i cocert to produce rapid, quality, cosistet Waters UPLC with O-lie SPE Techology ca be used with a rage of Waters Waters UPLC with O-lie SPE Techology provides excellet data reproducibility Waters UPLC with O-lie SPE UPLC pressure eabled o-lie results. System compoets iclude: high-performace optical ad mass detectors your laboratory will have the ad liearity. Results from 1 cosecutive ijectios with a pesticide at 2 ppt Techology provides advaced data ACQUITY UPLC Quaterary Solvet Maager (QSM) To load sample, flexibility to aalyze a wide variety of chemical compouds. show little variatio i peak areas or retetio times, with o degradatio i either maagemet capabilities to help wash, ad recoditio the extractio colum ACQUITY UPLC PDA ad FLR detectors Provide fast data acquisitio the extractio or aalytical colums. A 12-poit calibratio curve of cyaazie improve aalytical workflow. capabilities for rapid aalyses ad the sesitivity required for trace impurity demostrates accurate ad precise quatitatio capabilities. Completely iteg rated system you the ability to extract a wide Oasis HLB Direct Coect HP Colum, 2.1 x 3 mm, 2 μm XBridge C18 Direct Coect HP Colum, 2.1 x 3 mm, 1 μm Improve recovery ad reproducibility Evirometal Resource Associates (ERA), A Waters Compay separatio of the aalytes Oasis ad XBridge extractio colums ACQUITY UPLC aalytical colums 2777 Sample Maager Holds up to 648 x 2 ml samples or XBridge C 8 Direct Coect HP Colum, 2.1 x 3 mm, 1 μm ACQUITY UPLC Biary Solvet Maager (BSM) For elutio ad Xevo TQ MS ad Xevo TQ-S The ultimate i quatitative capabilities. Desiged to eable ucomplicated access to superior UPLC/MS/MS performace deliver the highest levels of sesitivity, selectivity, robustess, speed, 36 x 2 ml samples aalytical data, ERA offers ad accuracy. ACQUITY UPLC Detectors Photodiode Array (PDA), fluorescece (FLR), proficiecy testig, certified ad tadem quadrupole referece materials, ad stadards. ItelliStart Techology Automated mass spec setup ad optimizatio esure that users of To esure the quality of your with less breakthrough usig prove detectio ad quatificatio. 1 all skill levels ca quickly produce high quality results. ACQUITY TQD A smaller, easy-to-use, tadem quadrupole mass spectrometer that provides robust performace ad walk-up operatio. Eables accurate, Quapedia Rapidly create LC/MS/MS data acquisitio ad processig methods ad reproducible low-level quatitative aalysis with reduced matrix iterferece. seamlessly trasfer from oe UPLC with O-lie SPE system Oasis ad XBridge sample to aother. 1 preparatio chemistries. Extractio Colum Carbedazim Metolachlor 6.6 Atrazie Loadig Pump Autosampler Two Six-port Valves UPLC Sigle Port Aalytical Colum Detector 6.7 Figure 1. The UPLC with O-lie SPE Techology is a iovative cofiguratio of pumps ad colums that allows for loadig, washig, ad separatio to proceed i parallel, dramatically reducig aalysis times TargetLyx Applicatio Maager Quatify ad cofirm cotamiats while elimiatig time-cosumig, costly maual checks. Cyaazie12 poit calibratio from 1 to 5 ppt Compoud ame: Cyaazie Correlatio coefficiet: r= , r2= Respose type: exteral stadard, area Curve type: Liear, Origi: Exclude, Weightig: 1/x, Axis tras: Noe Elutio Pump Extractio Colum 6.8 Figure 4. Reproducibility of UPLC with O-lie SPE ad Xevo TQ MS. 1 overlayed extracted io chromatograms of carbedazim (192.5 > 16.5) at 2 ppt. Percetage RSD (o area) = Figure 3. Sesitivity of UPLC with O-lie SPE ad Xevo TQ MS. Extracted io chromatograms of pesticides at 1 ppt: Carbedazim (192. > 16.); atrazie (216.1 > 174.) ad metolachlor (284.3 > 252.1). Peak to peak sigal-to-oise (with o prior processig) are show for each compoud. MassLyx Mass Spectrometry Software For comprehesive istrumet cotrol ad data processig. 8 Respose rage of aalytes: SPE colum chemistries, givig Aalyze a wide rage of compoud types Coc 5 Figure 5. Liearity of UPLC with O-lie SPE ad ACQUITY TQD. Cyaazie 12-poit calibratio from 1 to 5 ppt.

4 Waters UPLC with O-lie SPE Techology is a completely itegrated solutio. Ultra sesitivity easily meet or e xceed detectio requiremets Excellet reproducibility ad liearity more cofidece i your results Advaced data maagemet Waters provides three distict Each compoet operates i cocert to produce rapid, quality, cosistet Waters UPLC with O-lie SPE Techology ca be used with a rage of Waters Waters UPLC with O-lie SPE Techology provides excellet data reproducibility Waters UPLC with O-lie SPE UPLC pressure eabled o-lie results. System compoets iclude: high-performace optical ad mass detectors your laboratory will have the ad liearity. Results from 1 cosecutive ijectios with a pesticide at 2 ppt Techology provides advaced data ACQUITY UPLC Quaterary Solvet Maager (QSM) To load sample, flexibility to aalyze a wide variety of chemical compouds. show little variatio i peak areas or retetio times, with o degradatio i either maagemet capabilities to help wash, ad recoditio the extractio colum ACQUITY UPLC PDA ad FLR detectors Provide fast data acquisitio the extractio or aalytical colums. A 12-poit calibratio curve of cyaazie improve aalytical workflow. capabilities for rapid aalyses ad the sesitivity required for trace impurity demostrates accurate ad precise quatitatio capabilities. Completely iteg rated system you the ability to extract a wide Oasis HLB Direct Coect HP Colum, 2.1 x 3 mm, 2 μm XBridge C18 Direct Coect HP Colum, 2.1 x 3 mm, 1 μm Improve recovery ad reproducibility Evirometal Resource Associates (ERA), A Waters Compay separatio of the aalytes Oasis ad XBridge extractio colums ACQUITY UPLC aalytical colums 2777 Sample Maager Holds up to 648 x 2 ml samples or XBridge C 8 Direct Coect HP Colum, 2.1 x 3 mm, 1 μm ACQUITY UPLC Biary Solvet Maager (BSM) For elutio ad Xevo TQ MS ad Xevo TQ-S The ultimate i quatitative capabilities. Desiged to eable ucomplicated access to superior UPLC/MS/MS performace deliver the highest levels of sesitivity, selectivity, robustess, speed, 36 x 2 ml samples aalytical data, ERA offers ad accuracy. ACQUITY UPLC Detectors Photodiode Array (PDA), fluorescece (FLR), proficiecy testig, certified ad tadem quadrupole referece materials, ad stadards. ItelliStart Techology Automated mass spec setup ad optimizatio esure that users of To esure the quality of your with less breakthrough usig prove detectio ad quatificatio. 1 all skill levels ca quickly produce high quality results. ACQUITY TQD A smaller, easy-to-use, tadem quadrupole mass spectrometer that provides robust performace ad walk-up operatio. Eables accurate, Quapedia Rapidly create LC/MS/MS data acquisitio ad processig methods ad reproducible low-level quatitative aalysis with reduced matrix iterferece. seamlessly trasfer from oe UPLC with O-lie SPE system Oasis ad XBridge sample to aother. 1 preparatio chemistries. Extractio Colum Carbedazim Metolachlor 6.6 Atrazie Loadig Pump Autosampler Two Six-port Valves UPLC Sigle Port Aalytical Colum Detector 6.7 Figure 1. The UPLC with O-lie SPE Techology is a iovative cofiguratio of pumps ad colums that allows for loadig, washig, ad separatio to proceed i parallel, dramatically reducig aalysis times TargetLyx Applicatio Maager Quatify ad cofirm cotamiats while elimiatig time-cosumig, costly maual checks. Cyaazie12 poit calibratio from 1 to 5 ppt Compoud ame: Cyaazie Correlatio coefficiet: r= , r2= Respose type: exteral stadard, area Curve type: Liear, Origi: Exclude, Weightig: 1/x, Axis tras: Noe Elutio Pump Extractio Colum 6.8 Figure 4. Reproducibility of UPLC with O-lie SPE ad Xevo TQ MS. 1 overlayed extracted io chromatograms of carbedazim (192.5 > 16.5) at 2 ppt. Percetage RSD (o area) = Figure 3. Sesitivity of UPLC with O-lie SPE ad Xevo TQ MS. Extracted io chromatograms of pesticides at 1 ppt: Carbedazim (192. > 16.); atrazie (216.1 > 174.) ad metolachlor (284.3 > 252.1). Peak to peak sigal-to-oise (with o prior processig) are show for each compoud. MassLyx Mass Spectrometry Software For comprehesive istrumet cotrol ad data processig. 8 Respose rage of aalytes: SPE colum chemistries, givig Aalyze a wide rage of compoud types Coc 5 Figure 5. Liearity of UPLC with O-lie SPE ad ACQUITY TQD. Cyaazie 12-poit calibratio from 1 to 5 ppt.

5 Waters UPLC with O-lie SPE Techology is a completely itegrated solutio. Ultra sesitivity easily meet or e xceed detectio requiremets Excellet reproducibility ad liearity more cofidece i your results Advaced data maagemet Waters provides three distict Each compoet operates i cocert to produce rapid, quality, cosistet Waters UPLC with O-lie SPE Techology ca be used with a rage of Waters Waters UPLC with O-lie SPE Techology provides excellet data reproducibility Waters UPLC with O-lie SPE UPLC pressure eabled o-lie results. System compoets iclude: high-performace optical ad mass detectors your laboratory will have the ad liearity. Results from 1 cosecutive ijectios with a pesticide at 2 ppt Techology provides advaced data ACQUITY UPLC Quaterary Solvet Maager (QSM) To load sample, flexibility to aalyze a wide variety of chemical compouds. show little variatio i peak areas or retetio times, with o degradatio i either maagemet capabilities to help wash, ad recoditio the extractio colum ACQUITY UPLC PDA ad FLR detectors Provide fast data acquisitio the extractio or aalytical colums. A 12-poit calibratio curve of cyaazie improve aalytical workflow. capabilities for rapid aalyses ad the sesitivity required for trace impurity demostrates accurate ad precise quatitatio capabilities. Completely iteg rated system you the ability to extract a wide Oasis HLB Direct Coect HP Colum, 2.1 x 3 mm, 2 μm XBridge C18 Direct Coect HP Colum, 2.1 x 3 mm, 1 μm Improve recovery ad reproducibility Evirometal Resource Associates (ERA), A Waters Compay separatio of the aalytes Oasis ad XBridge extractio colums ACQUITY UPLC aalytical colums 2777 Sample Maager Holds up to 648 x 2 ml samples or XBridge C 8 Direct Coect HP Colum, 2.1 x 3 mm, 1 μm ACQUITY UPLC Biary Solvet Maager (BSM) For elutio ad Xevo TQ MS ad Xevo TQ-S The ultimate i quatitative capabilities. Desiged to eable ucomplicated access to superior UPLC/MS/MS performace deliver the highest levels of sesitivity, selectivity, robustess, speed, 36 x 2 ml samples aalytical data, ERA offers ad accuracy. ACQUITY UPLC Detectors Photodiode Array (PDA), fluorescece (FLR), proficiecy testig, certified ad tadem quadrupole referece materials, ad stadards. ItelliStart Techology Automated mass spec setup ad optimizatio esure that users of To esure the quality of your with less breakthrough usig prove detectio ad quatificatio. 1 all skill levels ca quickly produce high quality results. ACQUITY TQD A smaller, easy-to-use, tadem quadrupole mass spectrometer that provides robust performace ad walk-up operatio. Eables accurate, Quapedia Rapidly create LC/MS/MS data acquisitio ad processig methods ad reproducible low-level quatitative aalysis with reduced matrix iterferece. seamlessly trasfer from oe UPLC with O-lie SPE system Oasis ad XBridge sample to aother. 1 preparatio chemistries. Extractio Colum Carbedazim Metolachlor 6.6 Atrazie Loadig Pump Autosampler Two Six-port Valves UPLC Sigle Port Aalytical Colum Detector 6.7 Figure 1. The UPLC with O-lie SPE Techology is a iovative cofiguratio of pumps ad colums that allows for loadig, washig, ad separatio to proceed i parallel, dramatically reducig aalysis times TargetLyx Applicatio Maager Quatify ad cofirm cotamiats while elimiatig time-cosumig, costly maual checks. Cyaazie12 poit calibratio from 1 to 5 ppt Compoud ame: Cyaazie Correlatio coefficiet: r= , r2= Respose type: exteral stadard, area Curve type: Liear, Origi: Exclude, Weightig: 1/x, Axis tras: Noe Elutio Pump Extractio Colum 6.8 Figure 4. Reproducibility of UPLC with O-lie SPE ad Xevo TQ MS. 1 overlayed extracted io chromatograms of carbedazim (192.5 > 16.5) at 2 ppt. Percetage RSD (o area) = Figure 3. Sesitivity of UPLC with O-lie SPE ad Xevo TQ MS. Extracted io chromatograms of pesticides at 1 ppt: Carbedazim (192. > 16.); atrazie (216.1 > 174.) ad metolachlor (284.3 > 252.1). Peak to peak sigal-to-oise (with o prior processig) are show for each compoud. MassLyx Mass Spectrometry Software For comprehesive istrumet cotrol ad data processig. 8 Respose rage of aalytes: SPE colum chemistries, givig Aalyze a wide rage of compoud types Coc 5 Figure 5. Liearity of UPLC with O-lie SPE ad ACQUITY TQD. Cyaazie 12-poit calibratio from 1 to 5 ppt.

6 [ F OL IO IN S IDE HE A DE R ] WAT E R S U P L C W I T H O N - L I N E S P E T E C H N O L O G Y Automated o-lie SPE with the performace of UPLC Miimize aalyst itervetio ad reduce sample volumes Performig off-lie SPE ad liquid/liquid extractio ca be UPLC with O-lie SPE Techology allows cleaup, cocetratio, labor itesive ad requires umerous vessel trasfers that ad direct elutio to the aalytical colum, which elimiates SAM P L E P RE PA RAT ION AND ANALYSIS IN MINUT ES ca icrease the likelihood of aalyst error. I additio, certai maual itervetio ad reduces sample volume. Sample vials Waters UPLC with O-lie SPE Techology dramatically streamlies the aalysis of water applicatios ca require large sample volumes ad tedious are loaded directly ito the autosampler for preparatio ad samples by providig aalyte extractio, cleaup, cocetratio, separatio, ad detectio sample preparatio. aalysis o additioal vessel trasfer is required. Oce samples i oe tur-key solutio. Automated sample hadlig, proprietary chromatographic media, ad are set up, aalysts are free to focus o more importat tasks. ultra-sesitive optical ad mass spectrometry detectio have bee combied ito a o-lie SPE/LC/MS/MS solutio that requires oly a fractio of the typical sample volume. O-lie SPE/LC/MS/MS for the detectio of: With the first UPLC-pressure eabled, aalytical scale o-lie SPE system, the time required Edocrie disruptors Fugicides Herbicides Pesticides Accommodate more samples ad ru them i less time. Persoal care products Flexibility Fuctios as a o-lie SPE system ad a stad aloe UPLC system with multiple Pharmaceuticals Soft drik awdditives Veteriary drug residues for preparatio ad aalysis, oce measured i hours, has bee reduced to miutes. Key beefits for laboratory operatios: Reduce sample preparatio ad aalysis times by over 9 Quality Automated sample processig esures reproducible results by elimiatig maual variability. Followig autosampler loadig, the sample is ijected oto a extractio colum packed with sorbet. Durig the loadig phase, target aalytes are trapped at high flow rates o the SPE sorbet, while uretaied iterfereces are directed to waste. Next, the sample is subjected to a mild wash, followed by elutio oto a high-resolutio aalytical colum for separatio ad aalysis. This cofiguratio allows the SPE extractio cartridges to be operated i parallel. Automated software tools, pre-loaded methods ad four solvet optios allow cleaup of the extractio colum to be easily optimized, miimizig aalyte carryover ad potetial iterfereces. Throughput Sample aalysis ad preparatio times reduced by up to 9. optical ad mass spectrometer detectio optios. Maximize laboratory asset utilizatio. Cost The use of sigificatly smaller sample volumes ca reduce shippig costs from remote locatios. With this o-lie cofiguratio, preparatio ad aalysis ca be reduced from up to 3 hours to as little as 15 miutes a reductio of over 9. other laboratory tasks. O-lie SPE with UPLC/MS/MS O the time required for sample SAMPLE PREP AND ANALYSIS METHOD Productivity Reduces sample processig time. Scietists ca allocate more time to UPLC with O-lie SPE Techology. Off-lie SPE with LC/MS/MS TIME (HOURS) Figure 2. Drikig water sample preparatio ad aalysis times. O-lie SPE with UPLC/MS/MS versus Off-lie SPE with LC/MS/MS. Waters, Xevo, UPLC, ACQUITY, ACQUITY UPLC, ad Oasis are registered trademarks of Waters Corporatio. XBridge, MassLyx, TargetLyx, Quapedia, ItelliStart, ad The Sciece of What s Possible are trademarks of Waters Corporatio. All other trademarks are the property of their respective owers. 21 Waters Corporatio. Prited i the U.S.A. Jauary EN AO-CP Waters Corporatio 34 Maple Street Milford, MA 1757 U.S.A. T: F: